- What is daclatasvir (Daklinza)?
- What are the uses for daclatasvir (Daklinza)?
- What are the side effects of daclatasvir (Daklinza)?
- What is the dosage for daclatasvir (Daklinza)?
- Which drugs or supplements interact with daclatasvir (Daklinza)?
- Is daclatasvir (Daklinza) safe to use during pregnancy or while breastfeeding?
- What else should I know about daclatasvir (Daklinza)?
What is daclatasvir (Daklinza)?
Daclatasvir (Daklinza) is an oral tablet used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 or 3. It belongs to a class of drugs called direct-acting antiviral agents (DAAs). Similar drugs include:
- boceprevir (Victrelis)
- sofosbuvir (Sovaldi)
- simeprevir (Olysio)
- telaprevir (Incivek)
- Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir)
- ledipasvir and sofosbuvir (Harvoni)
- elbasvir and grazoprevir (Zepatier)
What brand names are available for daclatasvir?
Daklinza is the only brand available for daclatasvir in the US.
Is daclatasvir (Daklinza) available as a generic drug?
Do I need a prescription for daclatasvir (Daklinza)?
What are the side effects of daclatasvir (Daklinza)?
Common side effects include:
Other side effects include:
Serious side effects include:
What is the dosage for daclatasvir (Daklinza)?
- The recommended dose of daclatasvir is 60 mg once daily with or without food for 12 weeks.
- Daclatasvir is used in combination with sofosbuvir.
- The dose should be reduced to 30 mg once daily when drugs that block the breakdown of daclatasvir are being used.
- The dose should be increased to 90 mg once daily when drugs that increase the breakdown of daclatasvir are being used. (See the drug interactions section for examples of interacting drugs.)
Which drugs or supplements interact with daclatasvir (Daklinza)?
Daclatasvir has many drug interactions.
- Rifampin, carbamazepine, phenytoin, and St. John's wort may reduce blood levels of daclatasvir and reduce its effectiveness by increasing its metabolism (break-down) in the intestine. Therefore, daclatasvir should not be combined with rifampin, carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125), or St. John's wort.
Other drugs that also may reduce blood levels of Daclatasvir include:
- nafcillin (Nafcil)
- bosentan (Tracleer)
- nevirapine (Viramune)
- dexamethasone (Decadron)
- efavirenz (Sustiva)
- atazanavir (Reyataz)
- darunavir (Prezista)
- lopinavir/ritonavir (Kaletra)
- etravirine (Intelence)
- modafanil (Provigil)
Drugs that increase blood levels of daclatasvir by reducing its break down in the liver include:
- atazanavir (Reyataz) with ritonavir (Norvir)
- nelfinavir (Viracept)
- indinavir (Crixivan)
- saquinavir (Invirase)
- clarithromycin (Biaxin)
- itraconazole (Sporanox)
- nefazodone (Serzone)
- posaconazole (Noxafil)
- telithromycin (Ketek)
- voriconazole (Vfend)
Daclatasvir increases blood levels of
Side effects of statins such as muscle pain should be monitored.
Daclatasvir also increases blood levels of
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Is daclatasvir (Daklinza) safe to use during pregnancy or while breastfeeding?
What else should I know about daclatasvir (Daklinza)?
What preparations of daclatasvir (Daklinza) are available?
- Tablets: 30 and 60 mg
How should I keep daclatasvir (Daklinza) stored?
- Daclatasvir should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).
How does daclatasvir (Daklinza) work?
- Daclatasvir directly blocks replication of HCV by interfering with a hepatitis C virus protein called nonstructural protein 5A (NS5A). Daclatasvir interferes with proteins and processes needed by hepatitis C virus to multiply and make new viruses, thus reducing the overall viral load. The efficacy of Daclatasvir has been established in subjects with hepatitis C virus genotypes 1 and 3.
- Daclatasvir is given with sofosbuvir and may be administered with or without ribavirin. In clinical studies, 95% of patients were cured after 12 weeks of treatment with daclatasvir plus sofosbuvir with or without ribavirin. Cure was defined as undetectable levels of hepatitis C virus in the blood when measured three months after the completion of treatment.
When was daclatasvir (Daklinza) approved by the FDA?
- The FDA approved daclatasvir in February 2016.
Daclatasvir (Daklinza) is a prescription medication used in combination with sofosbuvir to treat chronic hepatitis C (HCV) genotype 1 or 3 infection. Daclatasvir belongs to the class of drugs called direct-acting antiviral agents (DAAs). Side effects include diarrhea, insomnia, drowsiness, and rash.
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Related Disease Conditions
Liver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause and may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
The Digestion Process (Parts, Organs, and Functions)
Digestion is the complex process of turning the food you eat into the energy you need to survive. The digestive process also involves creating waste to be eliminated, and is made of a series of muscles that coordinate the movement of food. Learn more about digestion and the body parts that make it possible, including the mouth, pharynx, esophagus, stomach, small intestine, colon, rectum, anus, pancreas, liver, and gallbladder.
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation, scarring of the liver, infection of the liver, gallstones, cancer, toxins, genetic diseases, and blood flow problems. Symptoms of liver disease generally do not occur until the liver disease is advanced. Some symptoms of liver disease include jaundice, nausea and vomiting, easy bruising, bleeding excessively, fatigue, weakness, weight loss, shortness of breath, leg swelling, impotence, and confusion. Treatment of diseases of the liver depends on the cause.
Hepatitis (Viral Hepatitis A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or another virus (such as those that cause infectious mononucleosis, cytomegalovirus disease). The main nonviral causes of hepatitis are alcohol and drugs. Many patients infected with hepatitis A, B, and C have few or no symptoms of illness. For those who do develop symptoms of viral hepatitis, the most common are flu-like symptoms including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, and aching in the abdomen. Treatment of viral hepatitis is dependent on the type of hepatitis.
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Symptoms of chronic hepatitis include fatigue, fever, muscle aches, loss of appetite, and fever. Chronic hepatitis C may be cured in most individuals with drugs that target specific genomes of hepatitis C.
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like fatigue, jaundice, nausea and vomiting, anorexia, and abdominal discomfort. Hepatitis C is a contagious viral infection caused by persons sharing drug needles, surgical instruments that have not been properly sanitized, and organ transplantation.
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of hepatitis are contagious and some types are not. Hepatitis symptoms vary upon the type of disease; however, the following symptoms may develop in someone with hepatitis: fatigue, nausea and vomiting, abdominal pain and discomfort, jaundice (yellowing of the skin and whites of the eyes), and loss of appetite. Treatment for hepatitis depends upon the cause. Some types of hepatitis have a vaccine to prevent spread of disease such as hepatitis A and B.
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