- What is daclatasvir (Daklinza)?
- What brand names are available for daclatasvir?
- Is daclatasvir (Daklinza) available as a generic drug?
- Do I need a prescription for daclatasvir (Daklinza)?
- What are the uses for daclatasvir (Daklinza)?
- What are the side effects of daclatasvir (Daklinza)?
- What is the dosage for daclatasvir (Daklinza)?
- Which drugs or supplements interact with daclatasvir (Daklinza)?
- Is daclatasvir (Daklinza) safe to use during pregnancy or while breastfeeding?
- What else should I know about daclatasvir (Daklinza)?
What is daclatasvir (Daklinza)?
Daclatasvir (Daklinza) is an oral tablet used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 or 3. It belongs to a class of drugs called direct-acting antiviral agents (DAAs). Similar drugs include:
- boceprevir (Victrelis)
- sofosbuvir (Sovaldi)
- simeprevir (Olysio)
- telaprevir (Incivek)
- Viekira Pak (ombitasvir, paritaprevir, ritonavir, dasabuvir)
- ledipasvir and sofosbuvir (Harvoni)
- elbasvir and grazoprevir (Zepatier)
What are the uses for daclatasvir (Daklinza)?
What are the side effects of daclatasvir (Daklinza)?
Common side effects include:
Other side effects include:
Serious side effects include:
Quick GuideHepatitis C (Hep C) Symptoms and Treatment
What is the dosage for daclatasvir (Daklinza)?
- The recommended dose of daclatasvir is 60 mg once daily with or without food for 12 weeks.
- Daclatasvir is used in combination with sofosbuvir.
- The dose should be reduced to 30 mg once daily when drugs that block the breakdown of daclatasvir are being used.
- The dose should be increased to 90 mg once daily when drugs that increase the breakdown of daclatasvir are being used. (See the drug interactions section for examples of interacting drugs.)
Which drugs or supplements interact with daclatasvir (Daklinza)?
Daclatasvir has many drug interactions.
- Rifampin, carbamazepine, phenytoin, and St. John's wort may reduce blood levels of daclatasvir and reduce its effectiveness by increasing its metabolism (break-down) in the intestine. Therefore, daclatasvir should not be combined with rifampin, carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125), or St. John's wort.
Other drugs that also may reduce blood levels of Daclatasvir include:
- nafcillin (Nafcil)
- bosentan (Tracleer)
- nevirapine (Viramune)
- dexamethasone (Decadron)
- efavirenz (Sustiva)
- atazanavir (Reyataz)
- darunavir (Prezista)
- lopinavir/ritonavir (Kaletra)
- etravirine (Intelence)
- modafanil (Provigil)
Drugs that increase blood levels of daclatasvir by reducing its break down in the liver include:
- atazanavir (Reyataz) with ritonavir (Norvir)
- nelfinavir (Viracept)
- indinavir (Crixivan)
- saquinavir (Invirase)
- clarithromycin (Biaxin)
- itraconazole (Sporanox)
- nefazodone (Serzone)
- posaconazole (Noxafil)
- telithromycin (Ketek)
- voriconazole (Vfend)
Daclatasvir increases blood levels of
Side effects of statins such as muscle pain should be monitored.
Daclatasvir also increases blood levels of
Is daclatasvir (Daklinza) safe to use during pregnancy or while breastfeeding?
What else should I know about daclatasvir (Daklinza)?
What preparations of daclatasvir (Daklinza) are available?
- Tablets: 30 and 60 mg
How should I keep daclatasvir (Daklinza) stored?
- Daclatasvir should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).
How does daclatasvir (Daklinza) work?
- Daclatasvir directly blocks replication of HCV by interfering with a hepatitis C virus protein called nonstructural protein 5A (NS5A). Daclatasvir interferes with proteins and processes needed by hepatitis C virus to multiply and make new viruses, thus reducing the overall viral load. The efficacy of Daclatasvir has been established in subjects with hepatitis C virus genotypes 1 and 3.
- Daclatasvir is given with sofosbuvir and may be administered with or without ribavirin. In clinical studies, 95% of patients were cured after 12 weeks of treatment with daclatasvir plus sofosbuvir with or without ribavirin. Cure was defined as undetectable levels of hepatitis C virus in the blood when measured three months after the completion of treatment.
When was daclatasvir (Daklinza) approved by the FDA?
- The FDA approved daclatasvir in February 2016.
Daclatasvir (Daklinza) is a prescription medication used in combination with sofosbuvir to treat chronic hepatitis C (HCV) genotype 1 or 3 infection. Daclatasvir belongs to the class of drugs called direct-acting antiviral agents (DAAs). Side effects include:
Multimedia: Slideshows, Images & Quizzes
Hepatitis C Quiz: What is Hepatitis C?
How many Americans have hepatitis C? Take this quiz to learn the facts about this chronic disease....
Hepatitis C, Hep B, Hep A: Symptoms, Causes, Treatment
What is hepatitis? Hepatitis A, B, and C spread in different ways, causing mild to serious effects on the liver. Learn about...
Hepatitis: How Do You Get Hepatitis A, B, and C?
Hepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver...
Hepatitis C (Hep C) Symptoms and Treatment
What is Hepatitis C (Hep C, HVC)? Learn about hepatitis c symptoms, how you get hepatitis c, contagiousness, and hepatitis C...
Related Disease Conditions
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation,...
Hepatitis (Viral Hepatitis, A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or...
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion,...
The Digestion Process (Organs and Functions)
Digestion is the complex process of turning the food you eat into the energy you need to survive. The digestive process also...
Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as: gallstones, high...
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like: fatigue,...
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.