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What is Cystografin, and how does it work?
Cystografin (diatrizoate meglumine injection 30%) is a radiopaque contrast agent indicated for retrograde cystourethrography. Cystografin is injected into a urinary catheter during an X-ray in order to view the female bladder and uretha.
What are the side effects of Cystografin?
Common side effects of Cystografin include:
- injection site reactions,
- changes in taste sensation, and
- widening of blood vessels
What is the dosage for Cystografin?
Preparation of the Patient
The dose for retrograde use in cystography and voiding cystourethrography ranges from 25 to 300 mL depending on the age of the patient and the degree of bladder irritability; amounts greater than 300 mL may be used if the bladder capacity allows. Best results are obtained when the bladder is filled with the contrast agent. If desired, the preparation may be diluted with sterile water or sterile saline as indicated in the table below.
After sterile catheterization, the bladder should be filled to capacity with Cystografin using a suitable sterile administration set. Care should be taken to avoid using excessive pressure. The presence of bladder discomfort or reflux and/or spontaneous voiding usually indicates that the bladder is full.
The commonly employed radiographic techniques should be used. A scout film is recommended before the contrast agent is administered.
USE DILUTED SOLUTIONS IMMEDIATELY
|100 mL Bottle|
Sterile Water or Sterile Saline Added
|% Diatrizoate Meglumine w/v||% Organically Bound Iodine w/v||Total Volume|
|0 mL||30.0||14.1||100 mL|
|25 mL||24.0||11.3||125 mL|
|50 mL||20.0||9.4||150 mL|
|67 mL||18.0||8.5||167 mL|
|300 mL Bottle|
Sterile Water or Sterile Saline Added
|0 mL||30.0||14.1||300 mL|
|50 mL||25.7||12.1||350 mL|
Is Cystografin safe to use while pregnant or breastfeeding?
- Animal reproduction studies have not been conducted with diatrizoate meglumine injection.
- It is also not known whether diatrizoate meglumine injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
- Cystografin should be administered to a pregnant woman only if clearly needed.
- It is not known if Cystografin safe for use in nursing mothers.
Cystografin (diatrizoate meglumine injection 30%) is a radiopaque contrast agent indicated for retrograde cystourethrography, which is an X-ray used to view the female bladder and urethra. Common side effects of Cystografin include injection site reactions, cough, changes in taste sensation, and widening of blood vessels.
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Related Disease Conditions
Bladder Infection (Cystitis)
Bladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
A urethral stricture, or narrowing of the urethra, may cause decreased urine output. Symptoms include painful urination, urinary retention, and pelvic pain. Surgery is the only treatment for people with uncontrolled symptoms of urethral narrowing.
Treatment for bladder cancer depends on the stage of the disease, the grade of the tumor, and the type of bladder cancer. Options for treatment include surgery, radiation therapy, chemotherapy, and biological therapy.
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Interstitial Cystitis (IC) and Painful Bladder Syndrome (PBS)
Interstitial cystitis (IC)/painful bladder syndrome (PBS) is an inflammatory disease of the bladder that can cause ulceration and bleeding of the bladder's lining and can lead to scarring and stiffening of the bladder. Symptoms of interstitial cystitis may vary among individuals and may even vary with time in the same individual.
Overactive Bladder (OAB)
Overactive bladder is a sudden involuntary contraction of the muscle wall of the bladder causing urinary urgency (an immediate unstoppable need to urinate). Overactive bladder is is a form of urinary incontinence. Treatment options may include Kegel exercises, biofeedback, vaginal weight training, pelvic floor electrical stimulation, behavioral therapy, and medications.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
Urethral cancer is a rare form of cancer that primarily affects white females, people over 60 years of age, and those who have stds or who experience frequent urinary tract infections. Symptoms and signs of urethral cancer include blood in the urine, interrupted urine flow and discharge from the urethra. Treatment involves surgery, radiation therapy, and chemotherapy.
People who have bladder spasms, the sensation occurs suddenly and often severely. A spasm itself is the sudden, involuntary squeezing of a muscle. A bladder spasm, or "detrusor contraction," occurs when the bladder muscle squeezes suddenly without warning, causing an urgent need to release urine. The spasm can force urine from the bladder, causing leakage. When this happens, the condition is called urge incontinence or overactive bladder.
Nerve Disease and Bladder Control
A nerve problem might affect your bladder control if the nerves that are supposed to carry messages between the brain and the bladder do not work properly. Such problems include urine retention, poor control of sphincter muscles, and overactive bladder. Treatment depends upon the cause of the nerve damage and resulting type of bladder control problem.
Treatment & Diagnosis
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