What is Cystografin, and how does it work?
Cystografin (diatrizoate meglumine injection 30%) is a radiopaque contrast agent indicated for retrograde cystourethrography. Cystografin is injected into a urinary catheter during an X-ray in order to view the female bladder and uretha.
What are the side effects of Cystografin?
Common side effects of Cystografin include:
- injection site reactions,
- changes in taste sensation, and
- widening of blood vessels
What is the dosage for Cystografin?
Preparation of the Patient
Appropriate preparation is desirable for optimal results. A laxative the night before the examination and a low residue diet the day before the procedure are recommended.
The dose for retrograde use in cystography and voiding cystourethrography ranges from 25 to 300 mL depending on the age of the patient and the degree of bladder irritability; amounts greater than 300 mL may be used if the bladder capacity allows. Best results are obtained when the bladder is filled with the contrast agent. If desired, the preparation may be diluted with sterile water or sterile saline as indicated in the table below.
After sterile catheterization, the bladder should be filled to capacity with Cystografin using a suitable sterile administration set. Care should be taken to avoid using excessive pressure. The presence of bladder discomfort or reflux and/or spontaneous voiding usually indicates that the bladder is full.
The commonly employed radiographic techniques should be used. A scout film is recommended before the contrast agent is administered.
USE DILUTED SOLUTIONS IMMEDIATELY
|100 mL Bottle|
Sterile Water or Sterile Saline Added
|% Diatrizoate Meglumine w/v||% Organically Bound Iodine w/v||Total Volume|
|0 mL||30.0||14.1||100 mL|
|25 mL||24.0||11.3||125 mL|
|50 mL||20.0||9.4||150 mL|
|67 mL||18.0||8.5||167 mL|
|300 mL Bottle|
Sterile Water or Sterile Saline Added
|0 mL||30.0||14.1||300 mL|
|50 mL||25.7||12.1||350 mL|
Is Cystografin safe to use while pregnant or breastfeeding?
- Animal reproduction studies have not been conducted with diatrizoate meglumine injection.
- It is also not known whether diatrizoate meglumine injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
- Cystografin should be administered to a pregnant woman only if clearly needed.
- It is not known if Cystografin safe for use in nursing mothers.
Cystografin (diatrizoate meglumine injection 30%) is a radiopaque contrast agent indicated for retrograde cystourethrography, which is an X-ray used to view the female bladder and urethra. Common side effects of Cystografin include injection site reactions, cough, changes in taste sensation, and widening of blood vessels.
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Interstitial cystitis (IC)/painful bladder syndrome (PBS) is an inflammatory disease of the bladder that can cause ulceration and bleeding of the bladder's lining and can lead to scarring and stiffening of the bladder. Symptoms of interstitial cystitis may vary among individuals and may even vary with time in the same individual.
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Overactive bladder is a sudden involuntary contraction of the muscle wall of the bladder causing urinary urgency (an immediate unstoppable need to urinate). Overactive bladder is is a form of urinary incontinence. Treatment options may include Kegel exercises, biofeedback, vaginal weight training, pelvic floor electrical stimulation, behavioral therapy, and medications.
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