- What is Cyramza (ramucirumab) and how is it used?
- What are the most important side effects and other facts about Cyramza (ramucirumab)?
- Other side effects of Cyramza (ramucirumab)
- What is the dosage for Cyramza (ramucirumab)?
- Cyramza (ramucirumab) contraindications, pregnancy safety and drug interactions
What is Cyramza (ramucirumab) and how is it used?
Cyramza is a prescription medication used for cancer treatment, which is given through intravenous (IV) infusion.
Cyramza is a human vascular endothelial growth factor receptor 2 antagonist that specifically binds VEGF Receptor 2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. As a result, ramucirumab inhibits ligand-stimulated activation of VEGF Receptor 2, thereby inhibiting ligand-induced proliferation, and migration of human endothelial cells.
Cyramza is used to treat the following types of cancer:
- Advanced or Metastatic Stomach or Gastroesophageal (GE) Junction Cancer
- Metastatic Non-Small Cell Lung Cancer (NSCLC)
- Metastatic Colorectal Cancer (CRC)
- AFP-High Liver Cancer (Hepatocellular Carcinoma)
Cyramza is used in the following ways:
- By itself or in combination with paclitaxel, a chemotherapy medication, to treat stomach cancer.
- With the chemotherapy medication docetaxel to treat non-small cell lung cancer (NSCLC).
- With a combination of chemotherapy medications called FOLFIRI (irinotecan, folinic acid, and fluorouracil) to treat colorectal cancer (CRC).
- By itself to treat hepatocellular carcinoma (HCC), a type of liver cancer.
What are the most important side effects and other facts about Cyramza (ramucirumab)?
HEMORRHAGE, GASTROINTESTINAL PERFORATION, AND IMPAIRED WOUND HEALING
Cyramza increased the risk of hemorrhage and gastrointestinal hemorrhage, including severe and sometimes fatal hemorrhagic events. Permanently discontinue Cyramza in patients who experience severe bleeding.
Cyramza can increase the risk of gastrointestinal perforation, a potentially fatal event. Permanently discontinue Cyramza in patients who experience a gastrointestinal perforation.
Impaired Wound Healing
Impaired wound healing can occur with antibodies inhibiting the VEGF pathway. Discontinue Cyramza therapy in patients with impaired wound healing. Withhold Cyramza prior to surgery and discontinue Cyramza if a patient develops wound healing complications.
Other side effects of Cyramza (ramucirumab)
Cyramza can possibly cause serious side effects, including:
- Gastrointestinal Perforations
- Impaired Wound Healing
- Arterial Thromboembolic Events
- Infusion-Related Reactions
- Worsening of Pre-existing Hepatic Impairment
- Reversible Posterior Leukoencephalopathy SyndromeProteinuria Including Nephrotic Syndrome Thyroid Dysfunction
What is the dosage for Cyramza (ramucirumab)?
For intravenous infusion only. Do not administer as an intravenous push or bolus.
The recommended dose of Cyramza either as a single agent or in combination with weekly paclitaxel is 8 mg/kg every 2 weeks.
Non-Small Cell Lung Cancer
Administer Cyramza at 10 mg/kg intravenously on day 1 of a 21-day cycle prior to docetaxel infusion.
Administer Cyramza at 8 mg/kg intravenously every 2 weeks, prior to FOLFIRI administration.
Cyramza (ramucirumab) contraindications, pregnancy safety and drug interactions
- The safety and effectiveness of Cyramza in pediatric patients have not been established.
- Based on its mechanism of action, Cyramza can cause fetal harm. Animal models link angiogenesis, VEGF and VEGF Receptor 2 (VEGFR2) to critical aspects of female reproduction, embryofetal development, and postnatal development. There are no available data on Cyramza use in pregnant women to inform any drug-associated risks
- There is no information on the presence of ramucirumab in human milk, the effects on the breast-fed infant, or the effects on milk production.
- Based on animal data, Cyramza may impair fertility.
Latest Cancer News
Daily Health News
Cyramza (ramucirumab) is a prescription medication used for cancer treatment, which is given through intravenous (IV) infusion. Cyramza is a human vascular endothelial growth factor receptor 2 antagonist that specifically binds VEGF Receptor 2 and blocks binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. As a result, ramucirumab inhibits ligand-stimulated activation of VEGF Receptor 2, thereby inhibiting ligand-induced proliferation, and migration of human endothelial cells. Cyramza is used to treat the following types of cancer: Advanced or Metastatic Stomach or Gastroesophageal (GE) Junction Cancer, Metastatic Non-Small Cell Lung Cancer (NSCLC), Metastatic Colorectal Cancer (CRC), and AFP-High Liver Cancer (Hepatocellular Carcinoma). Serious side effects of Cyramza include hemorrhage, gastrointestinal perforation, impaired wound healing, and more. The safety and effectiveness of Cyramza in pediatric patients have not been established. Cyramza can cause fetal harm and impair fertility. It is not known if Cyramza is secreted in breast milk.
Multimedia: Slideshows, Images & Quizzes
Understanding Cancer: Metastasis, Stages of Cancer, and More
Learn the basics about cancer including types, causes, how it spreads, symptoms and signs, stages and treatment options. Read...
Colon Cancer: Symptoms, Signs, Screening, Stages
Colorectal cancer (colon cancer) is the cause of many cancer deaths. Learn about the warning signs, symptoms, screening process,...
Pancreatic Cancer Symptoms, Causes, and Treatment
Learn about pancreatic cancer signs, symptoms, causes, statistics, treatment and side effects (chemotherapy, radiation, surgery,...
Colon Cancer: How Your Diet Can Affect Colorectal Cancer
Diet, including nutrient, antioxidant, and vitamin intake, affects colon cancer risk. Certain dietary factors either decrease or...
Cancer-Fighting Foods in Pictures: Resveratrol, Green Tea, and More
Experts have praised certain foods for their ability to reduce cancer risks. Learn which foods and eating strategies may help...
Lung Cancer Symptoms, Stages, Treatment
Learn about lung cancer symptoms and treatments. Get more information on small cell lung cancer, non-small cell lung cancer, and...
Lung Cancer Risks: Myths and Facts
Learn about lung cancer myths and facts. Explore how cigar smoke, menthol, and pollution can increase your risk of lung cancer...
Colorectal (Colon) Cancer Quiz: Test Your Medical IQ
What is colorectal (colon) cancer and who gets it? Take this quiz to find out how this disease may be prevented.
Lung Cancer Quiz: Signs and Symptoms
Lung cancer is the number one cause of cancer deaths in both men and women in the U.S. and worldwide. Get the facts about lung...
Top 10 Cancers Quiz
Take this quiz to learn the causes of cancer. Get the facts about the causes, symptoms, and treatments for the world's most...
Gastric Cancer Quiz
What are the main risk factors for gastric cancer? Where does gastric cancer occur? Take this quiz to learn about this different...
Picture of Pancreatic Cancer
An abdominal CT scan shows a small, vaguely seen 2-cm pancreatic adenocarcinoma (mass) causing obstruction of both the common...
Picture of Pancreatic Cancer Tumor
This is a gross section of a malignant tumor of the pancreas resected from the pancreatic body and tail. See a picture of...
Picture of Lung Cancer
Cancer of the lung, like all cancers, results from an abnormality in the body's basic unit of life, the cell. See a picture of...
Picture of Colon Cancer
Most, if not all, of these cancers develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer....
Picture of Skin Cancer
Excessive exposure to sunlight is the main cause of skin cancer. See a picture of Skin Cancer and learn more about the health...
Gastric (Stomach) Cancer: Types, Causes, Symptoms, Treatment
What are the common signs and symptoms of stomach cancer? Learn about gastric cancer diagnosis, treatment, and their risks, how...
Cancer: How to Lower and Cut Your Risk of Cancer
About a third of all cases of cancer can be prevented. Find out how to lower your chances of getting it.
Cancer: Does This Cause Cancer?
Everything gives you cancer, right? Not really. WebMD's slide show tells you about the research into cancer and cell phones,...
Cancer: Cancer 'Remedies' That Don't Work
You may have read about an all-natural cure for cancer. While many therapies are helpful, some aren't worth your time or money....
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Colon cancer (bowel cancer) is a malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer.
Liver cancer is cancer of the liver cells (hepatocellular carcinoma) or of the ducts in the liver (cholangiocarcinoma). Liver cancer often arises due to liver damage, cirrhosis (scarring) caused by alcohol use/abuse, hepatitis B, or hepatitis C. Liver cancer may not cause any symptoms. Liver cancer is diagnosed with blood tests, imaging tests, and a liver biopsy. Treatment for liver cancer may include surgery, ablation, embolization, radiation, chemotherapy, and targeted therapy.
Colon Polyps: Symptoms, Causes, Cancer Risk, Treatment, and Prevention
Colon polyps are common growths on the inner lining of the colon. Colon polyps may become cancerous. There are several different types of colon polyps, and the chance of the polyp becoming cancerous depends on the type, size, and histology. Blood in the stool or rectal bleeding are the most common symptoms of colon polyps. Treatment for colon polyps depend on the type, size, and histology.
Pancreatic cancer is a malignant tumor of the pancreas. Pancreatic cancer has been called a "silent" disease because early pancreatic cancer usually does not cause early symptoms. Typically, pancreatic cancer has metastasized (spread to adjacent organs, such as the liver) by the time most people receive a dignosis of pancreatic cancer. Symptoms and signs usually appear later in the course of the disease and include jaundice, back pain, nausea, weight loss, itching, and loss of appetite. Treatment depends upon the type of pancreatic cancer but may include surgery, chemotherapy, and/or radiation therapy.
Lung cancer kills more men and women than any other form of cancer. Eight out of 10 lung cancers are due to tobacco smoke. Lung cancers are classified as either small-cell or non-small-cell lung cancers.
Cancer Risk Factors
Though it's difficult to say why some people develop cancer while others don't, research shows that certain risk factors increase a person's odds of developing cancer. These risk factors include growing older, family history of cancer, diet, alcohol and tobacco use, and exposure to sunlight, ionizing radiation, certain chemicals, and some viruses and bacteria.
Larynx Cancer (Throat Cancer)
Symptoms and signs of cancer of the larynx, the organ at the front of the neck, include hoarseness, a lump in the neck, sore throat, cough, problems breathing, bad breath, earache, and weight loss. Treatment for larynx cancer depends on the stage (the extent) of the disease. Radiation therapy, surgery, and chemotherapy are all forms of treatment for laryngeal cancer.
There are four major types of thyroid cancer: papillary, follicular, medullary, and anaplastic thyroid cancer. Tumors on the thyroid are referred to as thyroid nodules. Symptoms of thyroid cancer include swollen lymph nodes, pain in the throat, difficulty swallowing, hoarseness, and a lump near the Adam's apple. Treatment usually involves chemotherapy, surgery, radioactive iodine, hormone treatment or external radiation and depends upon the type of thyroid cancer, the patient's age, the tumor size, and whether the cancer has metastasized.
Esophageal cancer is a disease in which malignant cells form in the esophagus. Risk factors of cancer of the esophagus include smoking, heavy alcohol use, Barrett's esophagus, being male and being over age 60. Severe weight loss, vomiting, hoarseness, coughing up blood, painful swallowing, and pain in the throat or back are symptoms. Treatment depends upon the size, location and staging of the cancer and the health of the patient.
Early Warning Signs and Stages of Colon Cancer
Colon cancer or colorectal cancer, is a type of cancer that begins in the cells lining the large intestine (colon). In the early stages of colon cancer, warning signs and symptoms usually don’t occur. Colon cancer usually does not have any signs or symptoms. As the cancer grows and expands it may begin to produce signs and symptoms, for example, diarrhea, constipation, blood in the stool, and narrow or pencil-thin stools.There are four stages of colon cancer; however, The term Stage 0 is sometimes used for a very early cancer that only affects the lining of the intestine. The other stages of colon cancer are stage 1, 2, 3, and 4.
Small Cell Lung Cancer vs. Non-Small Cell Lung Cancer
Non-small cell lung cancers (NSCLC) consist of large cell carcinomas, adenocarcinomas, and squamous cell carcinomas. Small cell lung cancer (SCLC) usually starts in the bronchi and typically appears in those who smoke. SCLC and NSCLC are staged in different manners, and SCLC tends to metastasize more quickly than NSCLC. Signs and symptoms of NSCLC and SCLC include shortness of breath, coughing up blood, recurring lung infections, and chest pain. Treatment may involve radiation therapy, chemotherapy, and surgery.
Though the cause of stomach cancer is unknown, risk factors for stomach cancer include diet, H. pylori infection, smoking age, gastritis, stomach surgery, family history, and pernicious anemia. Symptoms include stomach discomfort, feeling full after a small meal, nausea and vomiting, and weight loss. Treatment depends upon staging and may involve surgery, radiation therapy, or chemotherapy.
Second Source article from Government
Second Source article from Government
Second Source article from Government
There are several types of kidney cancer, including renal cell cancer (renal adenocarcinoma or hypernephroma), transitional cell carcinoma, and Wilms tumor. Symptoms of kidney cancer include blood in the urine, an abdominal lump or mass, chronic pain in the side, and tiredness. Treatment of kidney cancer -- which may include surgery, arterial embolization, radiation therapy, biological therapy or chemotherapy -- depends upon the stage of the disease and the patient's overall health.
Salivary Gland Cancer
Salivary gland cancer is cancer that affects the parotid glands, sublingual glands, or the submandibular glands. Risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain substances at work. Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. Treatment depends upon the stage of the cancer and usually involves surgery, radiation therapy, chemotherapy, or radiosensitizers.
Is Cancer Contagious?
Cancer is an abnormal growth of cells. A variety of parasites and viruses have been linked to various cancers. Cancer may metastasize, spreading from its original location to other organs. If you have cancer, you should seek medical care immediately if you experience high fever, shortness of breath, intense headaches, vomiting blood or passing blood rectally, chest pain or moderate to severe weakness, passing out (fainting), mental status changes, or seizures.
Cancer fatigue is a lack of energy that is caused by cancer or cancer treatment, including chemotherapy, radiation, biological therapy, or bone marrow transplantation. Strategies to combat cancer fatigue include scheduling rest, pacing oneself, planning ahead and prioritizing work and activities, eating the right foods, exercising, and practicing proper body mechanics.
Certain behavioral, lifestyle, and environmental factors contribute to cancer. Cancer prevention involves modifying these factors to decrease cancer risk. Tobacco use, alcohol consumption, physical inactivity, inadequate fruit and vegetable intake, and obesity increase the risk of certain cancers. Vaccines, genetic testing, and cancer screening also play a role in cancer prevention.
Colon Cancer Prevention
Colorectal cancer is both curable and preventable if it is detected early and completely removed before the cancerous cells metastasize to other parts of the body. Colonoscopy and flexible sigmoidoscopy (along with digital rectal examination and stool occult blood testing) are both effective at preventing colo-rectal cancers and detecting early colo-rectal cancers.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
What Is the BRCA Gene?
BRCA genes (BRCA 1 and 2, when normal, repair damaged DNA) are among the genetic mutations linked to breast cancer, ovarian cancer, and other cancers when mutated. Every woman with a BRCA mutation is at high risk for breast cancer, irrespective of whether she has a family history of breast cancer or not. By age 80, a woman with a BRCA mutation has about an 80% chance of developing breast cancer. BRCA1 and BRCA2 gene mutations also increase the risk of ovarian cancer, by 54% and 23%, respectively.
Liver Cancer (Hepatocellular Cancer) Prevention
Avoiding certain risk factors (such as hepatitis B and C, cirrhosis, and aflatoxin) can lower one's risk of developing liver cancer. Getting the hepatitis B vaccine is a protective factor against liver cancer.
Cancer survivors face ongoing physical, mental, occupational, and relationship challenges. Cancer survivors must coordinate follow-up care with the doctor and develop a wellness plan to stay healthy. This includes reducing stress, eating well, and exercising to support optimal health and minimize the risk of the cancer returning.
Treatment & Diagnosis
- Colon Cancer
- Liver Cancer
- Lung Cancer
- Small Intestine Cancer
- Colon Cancer Update with The Cleveland Clinic
- Lung Cancer Q & A
- Colorectal Cancer Issues: An Update with Doctors
- Mind-Body Medicine for Cancer Patients
- Colon Cancer Update: James Church, MD
- Nutrition: Fighting Cancer With Food
- Colon Cancer Update
- Cancer FAQs
- Lung Cancer FAQs
- Gastric Cancer FAQs
- Colorectal (Colon) Cancer FAQs
- Colon Cancer Prevention And Fiber?
- Esophageal Cancer Linked to Heartburn
- Colon Cancer and Polyp Screening Guidelines
- Cancer Survivor?
- Colon Cancer Silences Howard Keel
- Colon Cancer, The Genetic Factor
- Lung Cancer and Chemotherapy
- How Long Do You Live After Being Diagnosed with Colon Cancer?
- Stage IV Colon Cancer That Has Spread to the Liver
- Does HIV Cause Colorectal Cancer?
- How Do You Test for Stomach Cancer?
- How Does Colon Cancer Affect a Person's Body?
- Red Meats and Processed Meats Raise Cancer Risk
- Liver Cancer Diagnosis
- Liver Cancer Treatment
- Stage IV Lung Cancer With ALK (Anaplastic Lymphoma Kinase) Rearrangement
- Cancer Prevention: The Anticancer Diet
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.