- Related Diseases
- Images & Quizzes
- Eye Diseases Pictures Slideshow
- Pink Eye Slideshow Pictures
- Eyes and Eye Conditions Quiz
- What is cyclosporine-ophthalmic, and how does it work (mechanism of action)?
- What brand names are available for cyclosporine-ophthalmic?
- Is cyclosporine-ophthalmic available as a generic drug?
- Do I need a prescription for cyclosporine-ophthalmic?
- What are the side effects of cyclosporine-ophthalmic?
- What is the dosage for cyclosporine-ophthalmic?
- Which drugs or supplements interact with cyclosporine-ophthalmic?
- Is cyclosporine-ophthalmic safe to take if I'm pregnant or breastfeeding?
- What else should I know about cyclosporine-ophthalmic?
What is cyclosporine-ophthalmic, and how does it work (mechanism of action)?
Restasis ophthalmic emulsion is a prescription eye drop that helps patients increase their eyes' natural ability to produce tears. It is used to treat a type of chronic dry eye condition caused by inflammation. Cyclosporine, the medicine in Restasis, is also available in oral and injectable formulations that are used to treat various conditions including treatment or prevention of rejection of transplanted organs, psoriasis, and rheumatoid arthritis. Following oral administration or injection, cyclosporine is absorbed in the blood stream and works systemically to suppress the body's immune system. However, cyclosporine eye drop emulsion is thought to work differently. Restasis is believed to work locally in the eye as a partial modulator of the immune system. Tear production is thought to be decreased when lymphocytes, a type of white blood cell of the immune system, die and accumulate in the tear glands. Restasis reverses this condition, increasing tear production. Restasis does not produce its effect immediately. An increase in tear production may not be noticed until 3 to 6 months after starting treatment. Restasis ophthalmic emulsion was approved by the FDA in January, 2003.
What are the side effects of cyclosporine-ophthalmic?
The most common side effect of cyclosporine ophthalmic emulsion is a temporary burning sensation in the eye. Other side effects include:
What is the dosage for cyclosporine-ophthalmic?
One drop should be instilled in each eye twice daily. Patients may use Restasis with artificial tears or over-the-counter eye lubricants, allowing a 15 minute interval between products.
Restasis should not be used while wearing contact lenses. Patients with chronic dry eye are generally advised not to wear contact lenses. If contact lenses are worn, they should be removed before applying Restasis. Lenses may be inserted 15 minutes after applying Restasis.
The safety and effectiveness of Restasis has not been established in children below the age of 16.
Which drugs or supplements interact with cyclosporine-ophthalmic?
The effectiveness of Restasis may be affected if administered with other eye drops. Patients using other eye drops should consult with their eye doctor for advice. Patients may use Restasis with artificial tears or over-the-counter eye lubricants, allowing a 15 minute interval between products.
Is cyclosporine-ophthalmic safe to take if I'm pregnant or breastfeeding?
Due to the lack of conclusive safety data, Restasis should be used in pregnancy only if clearly needed. Restasis is classified as FDA pregnancy risk category C (it caused harm in studies with animals, but use during pregnancy in humans has not been adequately evaluated).
It is not known if cyclosporine is excreted into breast milk following administration into the eye. Although blood levels were undetectable following ophthalmic administration, Restasis should be used cautiously during nursing.
What else should I know about cyclosporine-ophthalmic?
What preparations of cyclosporine-ophthalmic are available?
Ophthalmic emulsion (eye drops): 0.5 mg/ml cyclosporine. Restasis is supplied in a sterile, preservative-free single-use vial.
How should I keep cyclosporine-ophthalmic stored?
Restasis should be stored at room temperature, between 15 C to 25 C (59 F to 77 F).
REFERENCE: FDA Prescribing Information
Daily Health News
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- cyclosporine, Restasis Related Diseases
- cyclosporine, Restasis Images & Quizzes
- cyclosporine, Restasis Index
Top cyclosporine-ophthalmic Related ArticlesComplete List
Dry EyesDry eyes are caused by an imbalance in the tear-flow system of the eye, but also can be caused by the drying out of the tear film. This can be due to dry air created by air conditioning, heat, or other environmental conditions. Treatment may involve self-care measures, medications, or rarely, surgery.
Eye Anatomy Detail PictureThe eye has a number of components which include but are not limited to the cornea, iris, pupil, lens, retina, macula, optic nerve, choroid and vitreous. See a picture of Eye Anatomy Detail and learn more about the health topic.
Eye CareMany common eye disorders resolve without treatment and some may be managed with over-the-counter (OTC) products. It's important to visit a physician or ophthalmologist is the problem involves the eyeball itself or the condition hasn't improved after 72 hours of use of an eye-care OTC product.
Eye Diseases SlideshowEye diseases can cause damage and blindness if not detected and treated soon enough. Learn the warning signs and symptoms of common eye conditions such as glaucoma, cataracts, pink eye, macular degeneration and more.
Eye StrainEye strain is a symptom caused by looking at something for a long time. Symptoms and signs include redness, light sensitivity, headaches, and blurred vision. Symptoms may be treated by closing the eyes and taking a break from the visual task.
Eye Conditions QuizWhat do you know about your eyes? Take this quick quiz to learn about a range of eye diseases and conditions.
LASEK Laser Eye SurgeryLASEK is a type of laser surgery that is used to correct astigmatism, nearsightedness, and farsightedness. The procedure involves cutting the outer layer of the cornea with a fine blade to correct vision. Potential side effects include dry eyes, cloudy vision, reduced vision, and the sensation of having a foreign object in the eye.
LASIK Eye SurgeryLASIK (laser in situ keratomileusis) eye surgery is a procedure in which a laser is used beneath the corneal flap to reshape the cornea. This process is used to:
- treat refractive errors,
- improve vision,
- and eliminate or reduce the need for contact lenses or glasses.
- conventional LASIK,
- wavefront-optimized LASIK,
- and wavefront-guided LASIK.
Pink Eye SlideshowTrying to get rid of pink eye? If you woke up with crusty eyelids and red, swollen eyes, you may have pink eye also called conjunctivitis. Find out how to diagnose and treat pink eye.
RA SlideshowWhat is rheumatoid arthritis (RA)? Learn about juvenile rheumatoid arthritis. Discover rheumatoid arthritis (RA) symptoms, diagnosis, and treatment.
ScleritisScleritis is inflammation of the white part of the eye. It may be caused by a serious underlying condition, such as an autoimmune disease. Symptoms include redness, pain, tearing, sensitivity to light, and decreased visual acuity. Treatment may include eye drops as well as treatment for any underlying disease process. Scleritis cannot be prevented.
Sjogren's SyndromeSjögren's syndrome is an autoimmune disease involving the abnormal production of extra antibodies that attack the glands and connective tissue. Sjögren's syndrome with gland inflammation (resulting dry eyes and mouth, etc.) that is not associated with another connective tissue disease is referred to as primary Sjögren's syndrome. Sjögren's syndrome that is also associated with a connective tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus, or scleroderma, is referred to as secondary Sjögren's syndrome. Though there is no cure for Sjögren's syndrome, the symptoms may be treated by using lubricating eye ointments, drinking plenty of water, humidifying the air, and using glycerin swabs. Medications are also available to treat dry eye and dry mouth.