- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What is cyclobenzaprine (Amrix, Fexmid, Flexeril)?
- What are the uses for cyclobenzaprine?
- What are the side effects of cyclobenzaprine?
- What is the dosage for cyclobenzaprine?
- Which drugs or supplements interact with cyclobenzaprine?
- Is cyclobenzaprine safe to use during pregnancy or while breastfeeding?
- What else should I know about cyclobenzaprine?
What is cyclobenzaprine (Amrix, Fexmid, Flexeril)?
Cyclobenzaprine is a muscle relaxant. Cyclobenzaprine relieves muscle spasm when the spasm is due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Cyclobenzaprine has no effect on muscle function. Cyclobenzaprine seems to accomplish its beneficial effect through a complex mechanism within the nervous system, probably in the brainstem.
What are the uses for cyclobenzaprine?
Cyclobenzaprine is used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. It is only for short-term use, up to two or three weeks.
What are the side effects of cyclobenzaprine?
The most common side effects of cyclobenzaprine include:
Other reported side effects include:
- Blurred vision,
- Unpleasant taste
- Acid reflux
- Abdominal pain or discomfort
Possible serious side effects include:
What is the dosage for cyclobenzaprine?
- The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets.
Which drugs or supplements interact with cyclobenzaprine?
- Cyclobenzaprine is chemically related to the tricyclic class of antidepressants, for example, amitriptyline (Elavil, Endep), nortriptyline Pamelor). As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together.
- Cyclobenzaprine interacts with other medications and drugs that slow the brain's processes, such as
Is cyclobenzaprine safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
- It is not known whether cyclobenzaprine is secreted in milk. However, since it is related to the tricyclic antidepressants, some of which are excreted in breast milk, caution is advised in using this medication in women who are breastfeeding.
What else should I know about cyclobenzaprine?
- Is available in generic form. You need a prescription for this drug.
- Is available as Tablets: 5 and 10 mg. and Capsules (Extended Release): 15 and 30 mg.
- Tablets should be stored between 15 C and 30 C (59 F and 86 F).
- Was approved by the FDA in August 1977
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
Cyclobenzaprine (Fexmid, Amrix, Flexeril) is a drug prescribed for the short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. Common side effects include dry mouth, fatigue, and headaches. Possible serious side effects include stroke, heart attacks, and heat stroke.
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication. The brand name Flexeril has been discontinued and is no longer available in the US.
Multimedia: Slideshows, Images & Quizzes
Back Pain Quiz: Test Your Back Pain IQ
There are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge...
Headaches Quiz: Learn About Headache Pain
If you're plagued with headaches, our Headaches Quiz may help you identify causes, triggers, symptoms, and treatments for...
Fibromyalgia Quiz: What Is Fibromyalgia?
Fibromyalgia could be the reason for your constant, deep bodily pain. Learn more about this painful condition with the...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Common Causes of Foot Pain
Learn about common causes of foot pain such as bunions, corns, athlete's foot, plantar warts and more. Get the latest information...
Back Pain: Find Relief, Treat Your Back Pain
Back pain conditions are very common. Learn the truth and get the facts behind myths, remedies, causes and treatment for back...
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Low Back Pain: Symptoms, Causes, Treatment, Relief
Do you suffer from low back pain? Watch this slideshow to see common triggers of lower back pain and what kind of treatments you...
Pain-Relief Tips for Bumps, Bruises, Sprains, and Strains in Pictures
View this First Aid slideshow on Care and Pain Relief. See how to get pain relief if you've bumped your head, sprained your...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Related Disease Conditions
Ankle pain is commonly due to a sprain or tendinitis. The severity of ankle sprains ranges from mild (which can resolve within...
Lower Back Pain
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae,...
Elbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Treatment includes ice, rest, and...
Fibromyalgia is a chronic pain condition characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress...
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee...
Sciatica pain, caused by irritation of the sciatic nerve, typically radiates from the low back to behind the thigh to below the...
Neck Pain (Cervical Pain)
Neck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain....
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Sprains and Strains
An injury to a ligament is called a sprain, and an injury to muscle or tendon is called a strain. Sprains and strains may be...
Whiplash is a common injury to a person's neck following a car accident (in most cases). Symptoms include: headache, neck...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph...
A herniated disc may be caused by injury or degeneration from age. Symptoms depend on the location of the herniation and whether...
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout),...
Muscle spasms are involuntary muscle contractions that come on suddenly and are usually quite painful. Dehydration, doing...
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff...
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and...
Treatment & Diagnosis
- Headaches FAQs
- Fibromyalgia FAQs
- Back Pain FAQs
- Pain FAQs
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Pain Management Resources
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.