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- What is cyclobenzaprine (Amrix, Fexmid, Flexeril)?
- What are the uses for cyclobenzaprine?
- What are the side effects of cyclobenzaprine?
- What is the dosage for cyclobenzaprine?
- Which drugs or supplements interact with cyclobenzaprine?
- Is cyclobenzaprine safe to use during pregnancy or while breastfeeding?
- What else should I know about cyclobenzaprine?
What is cyclobenzaprine (Amrix, Fexmid, Flexeril)?
Cyclobenzaprine is a muscle relaxant. Cyclobenzaprine relieves muscle spasm when the spasm is due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Cyclobenzaprine has no effect on muscle function. Cyclobenzaprine seems to accomplish its beneficial effect through a complex mechanism within the nervous system, probably in the brainstem.
What are the uses for cyclobenzaprine?
Cyclobenzaprine is used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. It is only for short-term use, up to two or three weeks.
What are the side effects of cyclobenzaprine?
The most common side effects of cyclobenzaprine include:
Other reported side effects include:
- Blurred vision,
- Unpleasant taste
- Acid reflux
- Abdominal pain or discomfort
Possible serious side effects include:
What is the dosage for cyclobenzaprine?
- The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets.
Which drugs or supplements interact with cyclobenzaprine?
- Cyclobenzaprine is chemically related to the tricyclic class of antidepressants, for example, amitriptyline (Elavil, Endep), nortriptyline Pamelor). As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together.
- Cyclobenzaprine interacts with other medications and drugs that slow the brain's processes, such as
Is cyclobenzaprine safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
- It is not known whether cyclobenzaprine is secreted in milk. However, since it is related to the tricyclic antidepressants, some of which are excreted in breast milk, caution is advised in using this medication in women who are breastfeeding.
What else should I know about cyclobenzaprine?
- Is available in generic form. You need a prescription for this drug.
- Is available as Tablets: 5 and 10 mg. and Capsules (Extended Release): 15 and 30 mg.
- Tablets should be stored between 15 C and 30 C (59 F and 86 F).
- Was approved by the FDA in August 1977
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
Cyclobenzaprine (Fexmid, Amrix, Flexeril) is a drug prescribed for the short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. Common side effects include dry mouth, fatigue, and headaches. Possible serious side effects include stroke, heart attacks, and heat stroke.
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication. The brand name Flexeril has been discontinued and is no longer available in the US.
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