Is Sarcoidosis Related to Crohn's or Prednisone?

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Ask the experts

I have had Crohn's disease for more than 20 years. I just had my third surgery in March and they did a liver biopsy and found granulomas on my liver. They think it might be due to prolonged use of prednisone. I read on MedicineNet that it could be sarcoidosis which is treated with prednisone. Is sarcoidosis related to Crohn's? Could it be related to prolonged use of prednisone? Is sarcoidosis dangerous? Is it curable? thanks so much for your help and concern.

Doctor's Response

Granulomas are collections of cells that have gathered in small "clumps" in response to immunologic signals, often to attack foreign substances. They are small, and can be seen only by examination of tissue under the microscope. They can be found in almost any tissue in the body, including the liver, in infectious and non-infectious diseases and in reactions to medications. In fact, granulomas are seen in approximately 5% of all liver biopsies, and sarcoidosis is responsible for approximately half of the granulomas. The other 50% of granulomas are caused by a wide variety of conditions other than sarcoidosis. Crohn's disease is commonly associated with granulomas, and they may even be found in the liver. Prednisone is not one of the drugs associated with granulomas.

Medical Author: Jay W. Marks, M.D.

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Reviewed on 1/11/2018
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