Medical Definition of Crick-Brenner experiment

Reviewed on 3/29/2021

Crick-Brenner experiment: An elegant and important experiment performed in 1961 by Francis Crick and Sydney Brenner. The experiment proved that the genetic code was a triplet code and that the triplets were not separted by "punctuation." Crick and Brenner demonstrated that a triplet of bases in the DNA determines an amino acid unit and a string of triplets thereby specifies the full sequence of amino acids in a protein. The Crick-Brenner experiment consisted of deleting bases, one by one, in the DNA and showing that only after three bases had been eliminated in close proximity did the DNA-transcribing system come back into correct phase.

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