Creutzfeldt-Jakob Disease: Symptoms & Signs

Medically Reviewed on 6/11/2020

Creutzfeldt-Jakob disease (CJD) is a rare, degenerative fatal brain disease that affects about one person out of every 1 million people per year worldwide.

The onset of symptoms of CJD usually occurs about age 60, and about 90% of those affected die within a year. Associated signs and symptoms can include

As the illness progresses, mental deterioration worsens and involuntary movements, blindness, and coma may occur.

Causes of Creutzfeldt-Jakob disease

In most cases of CJD, no cause is found. Other cases are related to an inherited mutation or exposure to brain or nervous system tissue from others, usually through certain medical procedures.

Other creutzfeldt-jakob disease symptoms and signs

  • Amnesia
  • Anxiety or Apathy
  • Blindness
  • Blurred Vision
  • Coma
  • Delusion
  • Dementia
  • Depression
  • Difficulty Speaking
  • Disorientation
  • Hallucination
  • Inability to Speak or Understand Language
  • Insomnia
  • Involuntary Movements
  • Jerking Muscle Spasms
  • Lack of Concentration
  • Mental Confusion
  • Overactive Reflexes
  • Personality Change
  • Problems With Coordination
  • Rhythmic Muscle Contractions
  • Slow Bodily Movement


The abbreviated term ADHD denotes the condition commonly known as: See Answer

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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.