- Deep Vein Thrombosis Slideshow Pictures
- Take the DVT and PE Quiz
- Spider & Varicose Veins Pictures Slideshow
- Coumadin vs. Plavix quick comparison of differences
- What is Coumadin? What is Plavix?
- What are the uses for Coumadin vs. Plavix?
- What are the side effects of Coumadin vs. Plavix?
- What is the dosage of Coumadin vs. Plavix?
- What are the drug interactions for Coumadin vs. Plavix?
- Are Coumadin or Plavix safe to take if I am pregnant or breastfeeding?
Coumadin vs. Plavix quick comparison of differences
- Coumadin (warfarin) and Plavix (clopidogrel bisulfate) are anticoagulant medications used to prevent blood clots, which can cause heart attacks and strokes. Coumadin and Plavix also may be prescribed for people with atrial fibrillation (AFib) because AFib increases the chance of blood clots that can cause a stroke.
- Side effects of Coumadin and Plavix that are similar and include:
- Side effects of Coumadin that are different from Plavix include:
- Side effects of Plavix that are different from Coumadin include:
What is Coumadin? What is Plavix?
Coumadin (warfarin) is an oral anticoagulant (a drug that inhibits the clotting of blood). Coumadin helps prevent the formation of blood clots and the extension of clots already formed, and minimizes the risk of embolization of blood clots to other vital organs such as the lungs and brain. Blood clots can occur in the veins of the lower extremities (deep venous thrombosis, DVT), and can break off and become lodged in blood vessels of the lung (pulmonary embolism), causing shortness of breath, chest pain, and even life-threatening shock. Blood clots also can occur in the atria of the heart during atrial fibrillation and around artificial heart valves. These clots also can break off and obstruct blood vessels in the brain, causing an embolic stroke with paralysis. The generic name for Coumadin is warfarin.
Plavix (clopidogrel bisulfate) is an antiplatelet drug used to prevent blood clots. Plavix is used to reduce the risk of heart attacks and strokes, particularly in people with a recent history of stroke or heart attack, and those with peripheral vascular disease (peripheral artery disease, PAD). Plavix works by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. Plavix belongs to a class of drugs called P2Y12 inhibitors. Other P2Y12 inhibitors include ticagrelor (Brilinta) and prasugrel (Effient). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the how it works. The generic name for Plavix is clopidogrel bisulfate.
Quick GuideDVT in Pictures: Symptoms of Deep Vein Thrombosis, Beyond Leg Pain and More
What are the uses for Coumadin vs. Plavix?
- Coumadin (warfarin) is used in treating people with deep vein thrombosis (DVT) to prevent extension of the clot, and to reduce the risk of pulmonary embolism.
- People with pulmonary embolism are treated with warfarin to prevent further emboli.
- Warfarin also is used in people with atrial fibrillation or artificial heart valves to reduce the risk of strokes, and after a heart attack.
- It also is helpful in preventing blood clots from forming in certain orthopedic surgeries such as knee or hip replacements.
- Warfarin is used in preventing closure of coronary artery stents due to clotting.
- Plavix (clopidogrel) is used for preventing strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack or have peripheral arterial disease (PAD). The combination of clopidogrel and aspirin is better than aspirin or clopidogrel alone in preventing another heart attack but the risk of bleeding is higher.
What are the side effects of Coumadin vs. Plavix?
Coumadin side effects
The two most serious side effects of warfarin include:
- Necrosis (gangrene) of the skin
Bleeding can occur in any organ or tissue. Bleeding around the brain can cause severe headache and paralysis. Bleeding in the joints can cause joint pain and swelling. Bleeding in the stomach or intestines can cause weakness, fainting spells, black tarry stools, vomiting of blood, or coffee ground material. Bleeding in the kidneys can cause back pain and blood in urine.
Other side effects include:
Plavix side effects
The tolerability of clopidogrel is similar to that of aspirin. The more common side effects of clopidogrel include:
- Abdominal pain
- chest pain,
- muscle aches,
- severe bleeding,
- allergic reactions,
- pancreatitis, and
- liver failure.
Ticlopidine (Ticlid) is an antiplatelet medication quite similar to clopidogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons. The risk of this dangerous side effect with clopidogrel is about 0.04%, much less than with ticlopidine but twice that of aspirin.
Clopidogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people. TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally. For comparison, the related drug, ticlodipine (Ticlid), causes TTP 17-50 times more frequently than clopidogrel.
What is the dosage of Coumadin vs. Plavix?
- Warfarin may be taken with or without food.
- Treatment usually is started at 2 to 5 mg once daily and the dose is adjusted based in INR tests.
- Patients typically require 2 to 10 mg of warfarin daily.
Frequent blood tests (INR test) are performed to measure the effect of warfarin and to adjust dosing. There are published INR ranges for the various uses of warfarin.
Since warfarin is metabolized (inactivated) by the liver and then excreted by the kidneys, dosages need to be lowered in patients with liver and kidney dysfunction.
- Clopidogrel bisulfate usually is taken once daily. It can be taken with or without food.
- The recommended dose for treating unstable angina or heart attack is 300 mg initially followed by 75 mg daily in combination with 75-325 mg of aspirin.
- Peripheral arterial disease or recent stroke is treated with 75 mg daily.
Clopidogrel is activated by enzymes in the liver to its active form. Individuals who have reduced activity of liver enzymes that activate clopidogrel due to liver disease may not adequately respond to clopidogrel. Alternative treatments should be used for these patients.
What are the drug interactions for Coumadin vs. Plavix?
Coumadin drug interactions
Many drugs, both prescription and nonprescription (OTC), can affect the anticoagulant action of warfarin or increase the risk of bleeding. Patients on warfarin should regularly consult their doctor before instituting any medications on their own. It also is advisable for patients on warfarin to carry identification such as bracelets to alert other health professionals to the presence of anticoagulation.
Drugs that increase the effect of warfarin by reducing the breakdown of warfarin include:
- amiodarone (Cordarone)
- trimethoprim/sulfamethoxazole (Bactrim)
- fluconazole (Diflucan)
- itraconazole (Sporanox)
- voriconazole (Vfend)
- zafirlukast (Accolate)
- ciprofloxacin (Cipro)
- atorvastatin (Lipitor)
- clarithromycin (Biaxin)
- fluoxetine (Prozac)
- indinavir (Crixivan)
- ritonavir (Norvir)
Drugs and herbal products that may reduce the effect of warfarin by increasing its breakdown include:
- St. John's wort
- carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol)
- bosentan (Tracleer)
Bleeding is increased by antiplatelet drugs such as aspirin and other nonsteroidal anti-inflammatory drugs (for example, ibuprofen [Motrin], naproxen [Alleve]), clopidogrel (Plavix), and prasugrel (Effient); serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac) and paroxetine (Paxil).
Foods with high vitamin K content (for example, green leafy vegetables) reduce the effect of warfarin. Maintenance of a consistent intake of vitamin K containing foods is important to avoid fluctuations in the effect of warfarin.
Plavix drug interactions
The combination of clopidogrel with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding. Examples of NSAIDs include:
- Ibuprofen (Motrin, Advil, Nuprin)
- naproxen (Naprosyn, Aleve)
- diclofenac (Voltaren)
- etodolac (Lodine)
- nabumetone (Relafen)
- fenoprofen (Nalfon)
- flurbiprofen (Ansaid)
- indomethacin (Indocin)
- detoprofen (Orudis, Oruvail),
- oxaprozin (Daypro)
- piroxicam (Feldene)
- sulindac (Clinoril)
- tolmetin (Tolectin)
- mefenamic acid (Ponstel)
Combining Plavix with warfarin (Coumadin) or other drugs that cause bleeding increases the risk of bleeding.
Clopidogrel is converted to its active form by enzymes in the liver. Drugs that reduce the activity of these enzymes, for example, omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium) may reduce the activity of clopidogrel and should not be used with clopidogrel.
Other drugs that also may react with clopidogrel in a similar way include:
Are Coumadin or Plavix safe to take if I am pregnant or breastfeeding?
- Warfarin should be avoided by pregnant women or women who may become pregnant. Birth defects and fetal bleeding have been reported.
- Available evidence suggests that warfarin is not secreted in breast milk.
- There are no adequate studies of clopidogrel in pregnant women.
- Studies in rats have shown that clopidogrel appears in breast milk; however, it is not known whether it also appears in human breast milk. Because of a potential for side effects in the nursing infant, the physician must weigh the potential benefits and possible risks before prescribing clopidogrel to nursing mothers.
Coumadin, brand name warfarin, and Plavix (clopidogrel), are drugs that break up blood clots and prevent blood clot formation. Coumadin is an anticoagulant and Plavix is an antiplatelet drug. Both Coumadin and Plavix are prescribed to treat deep vein thrombosis (DVT), blood clots in the lung (pulmonary embolism), peripheral artery or vascular disease, and to prevent heart attacks and strokes in individuals who have had either condition previously. Coumadin also to prevent strokes and further heart attacks in people with atrial fibrillation (Afib).
Coumadin and Plavix have similar side effects like rash, jaundice, and bleeding, possibly severe. Coumadin side effects that are different from Plavix include hair loss, bloating, diarrhea, and gangrene of the skin. Plavix side effects that are different from Coumadin include headache, itching, dizziness, abdominal pain, diarrhea, chest pain, pancreatitis, and muscle aches. Coumadin and Plavix should not be taken together.
Multimedia: Slideshows, Images & Quizzes
DVT (Deep Vein Thrombosis) and Pulmonary Embolism (PE) Quiz
Take the Deep Vein Thrombosis and Pulmonary Embolism Quiz to learn causes, symptoms, and treatments for these two dangerous...
Stroke Quiz: Test Your Medical IQ
Take the Stroke Quiz to learn about stroke risks, causes, treatment, and most importantly, prevention....
Sudden Cardiac Arrest - Test Your Heart Health IQ
Take the Sudden Cardiac Arrest Quiz. Learning about this potentially deadly condition may save a life....
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Picture of Peripheral Vascular Disease
Diabetes also affects the blood vessels and alters the flow of blood. See a picture of Peripheral Vascular Disease and learn more...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Blood Clot
Blood that has been converted from a liquid to a solid state. See a picture of Blood Clot and learn more about the health topic....
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Stroke Causes, Symptoms, and Recovery
What is a stroke? Learn about stroke symptoms like sudden numbness or weakness, confusion, vision problems, or problems with...
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
Atrial Fibrillation: Heart Symptoms, Diagnosis, & Afib Treatment
Atrial fibrillation is the most common type of abnormal heart rhythm. Atrial fibrillation or AF can lead to serious heart...
DVT in Pictures: Symptoms of Deep Vein Thrombosis, Beyond Leg Pain and More
Deep vein thrombosis (DVT) is a dangerous and sometimes fatal blood clot that occurs deep within the lower leg or thigh....
Related Disease Conditions
Angina (Symptoms, Causes, Types, Diagnosis, and Treatment)
Angina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning,...
Atrial Fibrillation (AFib) Symptoms, ECG, and Treatment Medications
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the...
Heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack...
Stroke (Signs, Symptoms, Warning Signs)
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding...
Peripheral Vascular Disease (PVD Symptoms, Signs, Causes, Treatments)
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and...
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management....
Stroke is the third leading killer in the United States. Some of the warning signs of stroke include sudden confusion, trouble...
Deep Vein Thrombosis (DVT, Blood Clot in the Legs)
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility,...
12 Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms,...
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures,...
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Transient Ischemic Attack (TIA, Mini-Stroke)
When a portion of the brain loses blood supply, through a blood clot or embolus, a transient ischemic attack (TIA, mini-stroke)...
Pulmonary Embolism (Blood Clot in the Lung)
A pulmonary embolism (PE) occurs when a piece of a blood clot from deep vein thrombosis (DVT) breaks off and travels to an artery...
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to...
Blood clots can occur in the venous and arterial vascular system. Blood clots can form in the heart, legs, arteries, veins,...
Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a...
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women...
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart...
14 Signs and Symptoms of Stroke (FAST)
Stroke is a serious medical condition. If you think you or someone you know is having a stroke call 911 immediately....
Atrial Fibrillation Symptoms (AFib Warning Signs)
Atrial fibrillation or AFib is a type of hear rhythm abnormality. Early warning signs and symptoms of atrial fibrillation...
Atrial Flutter vs. Atrial Fibrillation (What Are the Differences?)
Atrial flutter and atrial fibrillation (AFib) are two types of a heart problem called atrial tachycardia. Both of these...
Atrial Fibrillation vs. Ventricular Fibrillation (AFib vs VFib Symptoms, ECG Strips)
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the...
Stroke vs Aneurysm (Differences and Similarities)
A stroke or "brain attack" is caused because blood flow to an area of the brain has been cut off by a blood clot or by a weakened...
Heart Attack vs. Stroke Symptoms, Differences, and Similarities
Heart attack usually is caused by a clot that stops blood flow supplying oxygen to an area of heart muscle, which results in...
Heart Attack vs. Heartburn (Differences between Symptoms and Signs)
Heartburn is a symptom of another disease or medical problem and can be described as a feeling of burning in the chest...
Stroke vs. Mini-Stroke (TIA)
A stroke or "brain attack" occurs when a blood clot or artery ruptures within the brain. The rupture or clot causes...
Migraine and Stroke (Symptoms, Types, Causes, Treatment)
Migraine headache is a type of headache in which the exact cause is not known; however, they may be inherited, and certain...
Atrial Fibrillation (AFib) Treatment Drugs
Atrial fibrillation (also called Afib or Afib) is heart rhythm disorder that causes irregular, and often, a rapid heartbeat. The...
Treatment & Diagnosis
Medications & Supplements
Daily Health News
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top Coumadin vs Plavix Related Articles
Angina SymptomsAngina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning, squeezing, and aching. Coronary artery disease is the main cause of angina but there are other causes. Angina is diagnosed by taking the patient's medical history and performing tests such as an electrocardiogram (EKG), blood test, stress test, echocardiogram, cardiac CT scan, and heart catheterization. Treatment of angina usually includes lifestyle modification, medication, and sometimes, surgery. The risk of angina can be reduced by following a heart healthy lifestyle.
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm which involves irregular and often rapid beating of the heart. Symptoms may include heart palpitations, dizziness, fainting, fatigue, shortness of breath, and chest pain.
Atrial fibrillation treatment may include medication or procedures like cardioversion or ablation to normalize the heart rate.
A-Fib SlideshowAtrial fibrillation is the most common type of abnormal heart rhythm. Atrial fibrillation or AF can lead to serious heart complications like stroke. Risks associated with AFib are related to heart rhythm changes. Treating atrial fibrillation addresses these changes in heartbeat.
Deep Vein Thrombosis
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility, medications, smoking, cancer, genetic predisposition, and cancer. Symptoms of a deep vein thrombosis in a leg are
- warmth, and
Treatment for DVT include medications and surgery.
Heart AttackHeart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
Heart Attack and Atherosclerosis Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back. Women experience the same symptoms as men; however, they also may experience:
- Extreme fatigue
- Pain in the upper abdomen
Leading a healthy lifestyle with a heart healthy low-fat diet, and exercise can help prevent heart disease and heart attack.
Heart Attack Pathology: Photo EssayA heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures, and illustrations of diseased heart tissue and the mechanisms that lead to coronary artery disease, and possible heart attack. A coronary artery occlusion may be fatal, but most patients survive it. Death can occur when the occlusion leads to an abnormal heartbeat (severe arrhythmia) or death of heart muscle (extensive myocardial infarction).
Heart Attack Symptoms and Early Warning SignsRecognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms, including left arm pain and chest pain, are well known but other, more nonspecific symptoms may be associated with a heart attack. Nausea, vomiting, malaise, indigestion, sweating, shortness of breath, and fatigue may signal a heart attack. Heart attack symptoms and signs in women may differ from those in men.
Heart Disease SlideshowLearn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease diagnostic tests, treatments, and prevention strategies.
Heart Disease QuizTake our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes, symptoms, treatments, testing, and procedures for medically broken hearts.
Heart SymptomsHeart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs of a heart attack and know the symptoms that may require an immediate trip to the hospital.
Illustrations of the HeartThe muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more about the health topic.
Peripheral Vascular Disease
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. While there are many causes of peripheral vascular disease, doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis. Peripheral artery disease symptoms include intermittent leg pain while walking, leg pain at rest, numbness in the legs or feet, and poor wound healing in the legs or feet.
Treatment for peripheral artery disease include lifestyle measures, medication, angioplasty, and surgery.
Stroke SlideshowWhat is a stroke? Learn about stroke symptoms like sudden numbness or weakness, confusion, vision problems, or problems with coordination. Discover causes and recovery of a stroke.
Stroke PreventionStroke is the third leading killer in the United States. Some of the warning signs of stroke include sudden confusion, trouble seeing with one or both eyes, dizziness, loss of balance, and more. Stroke prevention and reatable risk factors for stroke include lowering high blood pressure, quit smoking, heart disease, diabetes control and prevention.
Take the Stroke QuizTake the Stroke Quiz to learn about stroke risks, causes, treatment, and most importantly, prevention.
Stroke Symptoms and TreatmentA stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic).
Symptoms of a stroke may include weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke.
Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
Cardiac Arrest QuizTake the Sudden Cardiac Arrest Quiz. Learning about this potentially deadly condition may save a life.