cosyntropin

Cosyntropin is a manufactured version of the body's natural adrenocorticotropin hormone (ACTH). ACTH is produced by the pituitary gland in the brain. It stimulates the adrenal gland to release steroids including hydrocortisone and cortisone, androgens, as well as aldosterone. Cosyntropin has the same activity as ACTH. The FDA approved Cosyntropin in April 1970.

Cortrosyn

GENERIC AVAILABLE: Yes

Yes

Adverse effects associated with the use of cosyntropin include slowed heart rate, high blood pressure, edema (fluid buildup) in limbs, and rapid heartbeat. Other adverse effects include rash as well as redness at the injection site. Side effects associated with corticosteroid use are also commonly reported with cosyntropin use. There have been rare reports of anaphylactic reactions.

The initial dose for adults is based on what the drug is being used for and whether it is being given intravenously or intramuscularly. For example, the intravenous dose in diagnosing adrenocortical insufficiency is 0.25 mg. Initial doses of 1 mg intramuscularly may be used when transferring from corticosteroids.

: Cosyntropin may increase the electrolyte loss during diuretic therapy.

It is unknown whether cosyntropin is excreted in breast milk and, therefore, should be used cautiously by mothers who are nursing.

What preparations of cosyntropin-injectable are available?

Powder (with and without preservatives) 0.25 mg; Solution: 0.25 mg/mL in 1 mL vial

How should I keep cosyntropin-injectable stored?

Cosyntropin powder should be stored at room temperature between 15 C to 30 C (59 F to 86 F). Cosyntropin solution and suspension should be stored under refrigeration between 2 C to 8 C (36 F to 46 F) and protected from light and freezing. Infusions are stable for 12 hours at room temperature.