- Related Diseases
- Images & Quizzes
- What Kind of Doctor Do I Need? Slideshow
- Dental (Oral) Health Quiz
- Causes of a Heart Attack Slideshow
- What is cosyntropin-injectable, and how does it work (mechanism of action)?
- What brand names are available for cosyntropin-injectable?
- Is cosyntropin-injectable available as a generic drug?
- Do I need a prescription for cosyntropin-injectable?
- What are the side effects of cosyntropin-injectable?
- What is the dosage for cosyntropin-injectable?
- Which drugs or supplements interact with cosyntropin-injectable?
- Is cosyntropin-injectable safe to take if I'm pregnant or breastfeeding?
- What else should I know about cosyntropin-injectable?
What is cosyntropin-injectable, and how does it work (mechanism of action)?
: Cosyntropin is a manufactured version of the body's natural adrenocorticotropin hormone (ACTH). ACTH is produced by the pituitary gland in the brain. It stimulates the adrenal gland to release steroids including hydrocortisone and cortisone, androgens, as well as aldosterone. Cosyntropin has the same activity as ACTH. The FDA approved Cosyntropin in April 1970.
What are the side effects of cosyntropin-injectable?
Adverse effects associated with the use of cosyntropin include slowed heart rate, high blood pressure, edema (fluid buildup) in limbs, and rapid heartbeat. Other adverse effects include rash as well as redness at the injection site. Side effects associated with corticosteroid use are also commonly reported with cosyntropin use. There have been rare reports of anaphylactic reactions.
What is the dosage for cosyntropin-injectable?
The initial dose for adults is based on what the drug is being used for and whether it is being given intravenously or intramuscularly. For example, the intravenous dose in diagnosing adrenocortical insufficiency is 0.25 mg. Initial doses of 1 mg intramuscularly may be used when transferring from corticosteroids.
Is cosyntropin-injectable safe to take if I'm pregnant or breastfeeding?
It is unknown whether cosyntropin is excreted in breast milk and, therefore, should be used cautiously by mothers who are nursing.
What else should I know about cosyntropin-injectable?
What preparations of cosyntropin-injectable are available?
Powder (with and without preservatives) 0.25 mg; Solution: 0.25 mg/mL in 1 mL vial
How should I keep cosyntropin-injectable stored?
Cosyntropin powder should be stored at room temperature between 15 C to 30 C (59 F to 86 F). Cosyntropin solution and suspension should be stored under refrigeration between 2 C to 8 C (36 F to 46 F) and protected from light and freezing. Infusions are stable for 12 hours at room temperature.
Medically reviewed by John Cunha, DO
REFERENCE: FDA Prescribing Information.
Daily Health News
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- cosyntropin (Cortrosyn) Related Diseases
- cosyntropin (Cortrosyn) Images & Quizzes
- cosyntropin (Cortrosyn) Index
REFERENCE: FDA Prescribing Information.
Top cosyntropin-injectable Related ArticlesComplete List
Addison DiseaseAddison disease is a hormonal (endocrine) disorder involving destruction of the adrenal glands (small glands adjacent to the kidneys). Diseased glands can no longer produce sufficient adrenal hormones (specifically cortisol) necessary for normal daily body functions. Symptoms include weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin. Treatment of Addison disease involves replacing, or substituting, the hormones that the adrenal glands are not making.
Addison's Disease PictureHyperpigmentation representing an accentuation of normal pigmentation of the hand of a patient with Addison's disease (left). See a picture of Addison's Disease and learn more about the health topic.