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- What is cosyntropin-injectable, and how does it work (mechanism of action)?
- What brand names are available for cosyntropin-injectable?
- Is cosyntropin-injectable available as a generic drug?
- Do I need a prescription for cosyntropin-injectable?
- What are the side effects of cosyntropin-injectable?
- What is the dosage for cosyntropin-injectable?
- Which drugs or supplements interact with cosyntropin-injectable?
- Is cosyntropin-injectable safe to take if I'm pregnant or breastfeeding?
- What else should I know about cosyntropin-injectable?
What is cosyntropin-injectable, and how does it work (mechanism of action)?
Cosyntropin is a manufactured version of the body's natural adrenocorticotropin hormone (ACTH). ACTH is produced by the pituitary gland in the brain. It stimulates the adrenal gland to release steroids including hydrocortisone and cortisone, androgens, as well as aldosterone. Cosyntropin has the same activity as ACTH. The FDA approved Cosyntropin in April 1970.
What are the side effects of cosyntropin-injectable?
Adverse effects associated with the use of cosyntropin include slowed heart rate, high blood pressure, edema (fluid buildup) in limbs, and rapid heartbeat. Other adverse effects include rash as well as redness at the injection site. Side effects associated with corticosteroid use are also commonly reported with cosyntropin use. There have been rare reports of anaphylactic reactions.
What is the dosage for cosyntropin-injectable?
The initial dose for adults is based on what the drug is being used for and whether it is being given intravenously or intramuscularly. For example, the intravenous dose in diagnosing adrenocortical insufficiency is 0.25 mg. Initial doses of 1 mg intramuscularly may be used when transferring from corticosteroids.
Which drugs or supplements interact with cosyntropin-injectable?
: Cosyntropin may increase the electrolyte loss during diuretic therapy.
Is cosyntropin-injectable safe to take if I'm pregnant or breastfeeding?
It is unknown whether cosyntropin is excreted in breast milk and, therefore, should be used cautiously by mothers who are nursing.
What else should I know about cosyntropin-injectable?
What preparations of cosyntropin-injectable are available?
Powder (with and without preservatives) 0.25 mg; Solution: 0.25 mg/mL in 1 mL vial
How should I keep cosyntropin-injectable stored?
Cosyntropin powder should be stored at room temperature between 15 C to 30 C (59 F to 86 F). Cosyntropin solution and suspension should be stored under refrigeration between 2 C to 8 C (36 F to 46 F) and protected from light and freezing. Infusions are stable for 12 hours at room temperature.
Latest Medications News
cosyntropin (Cortrosyn) is a drug used in diagnostic testing to determine the presence of primary versus secondary adrenocortical insufficiency. The intramuscular injection may be prescribed for other disease processes including hemolytic, ocular, endocrine, dermatologic, and collagen disorders. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to using this medication.
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Related Disease Conditions
Addison disease is a hormonal (endocrine) disorder involving destruction of the adrenal glands (small glands adjacent to the kidneys). Diseased glands can no longer produce sufficient adrenal hormones (specifically cortisol) necessary for normal daily body functions. Symptoms include weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin. Treatment of Addison disease involves replacing, or substituting, the hormones that the adrenal glands are not making.
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REFERENCE: FDA Prescribing Information.