Connective Tissue Disease: Symptoms & Signs

Medically Reviewed on 8/21/2020

Connective tissue diseases are a broad group of conditions that damage the connective tissues of the body. Connective tissues are framework tissues that hold the body together. Examples of connective tissue diseases include rheumatoid arthritis, lupus, polymyositis/dermatomyositis, Churg-Strauss syndrome, scleroderma, and Marfan syndrome.

The signs and symptoms of connective tissue disease vary according to the specific type of connective tissue disease. Common signs and symptoms can include

Other symptoms and signs can include

Cause of connective tissue disease

Autoimmune reactions in which the body's immune system mistakenly attacks and damages its own tissues cause many connective tissue diseases.

Other connective tissue disease symptoms and signs


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.