- What is Premarin? What is Premarin used for?
- What are the side effects of conjugated estrogens vaginal cream?
- What is the dosage for Premarin cream?
- Which drugs or supplements interact with Premarin cream?
- Is Premarin cream safe to take if I'm pregnant or breastfeeding?
- What else should I know about Premarin cream?
What is Premarin? What is Premarin used for?
Estrogens are one of the two major classes of female hormones. (Progestins comprise the second major class). Estrogens are used primarily to treat the symptoms of menopause and states in which there is a deficiency of estrogen, for example, among women who have had their estrogen-producing ovaries removed. Conjugated estrogens are a mixture of several different estrogens (estrogen salts) that are derived from natural sources and blended to approximate the composition of estrogens in the urine of pregnant horses. The main components are sodium estrone sulphate and sodium equilin sulfate. Estrogens have widespread effects on tissues in the body. Estrogens cause growth and development of the female sexual organs and maintain female sexual characteristics such as the growth of underarm and pubic hair, body contours, and skeleton. Estrogens also increase secretions from the cervix and growth of the inner lining of the uterus (endometrium). Conjugated estrogens were first approved by the FDA in 1938.
What brand names are available for conjugated estrogens vaginal cream?
Premarin Vaginal Cream
Is Premarin cream available as a generic drug?
Do I need a prescription for Premarin?
What are the side effects of Premarin?
Among the most common endocrine side effects are:
- breakthrough vaginal bleeding
- loss of periods,
- excessively prolonged periods,
- breast pain or
- breast enlargement, and
- changes in sexuality (increases or decreases in libido).
Other important side effects include:
- gallstones, and the gallstones may result in abdominal pain and require surgery.
- Migraine headaches, and
- retention of water (edema).
Melasma--tan or brown patches-- may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped.
Blood clots are an occasional, serious side effect of estrogen therapy and are dose-related. (The higher the dose of estrogen, the greater the risk of blood clots.) Cigarette smokers are at a higher risk than non-smokers for blood clots, and patients requiring estrogens should be encouraged to quit smoking.
Estrogens can promote thickening of the lining of the uterus (endometrial hyperplasia) and increase the risk of uterine cancer. At diagnosis, endometrial cancers in recipients of estrogens are generally at an earlier stage and are less aggressive when they are discovered. Survival from endometrial cancer also is better in women taking estrogens than in those not taking estrogens. The addition of a progestin to estrogen therapy offsets the risk of endometrial cancer. Conflicting data exists on the association between estrogens and breast cancer. There may be a small increase in risk. The effect of concomitant progestin therapy on the risk of estrogen-induced breast cancer is unclear. Conjugated estrogens are well-absorbed from the vagina and into the blood. The amount absorbed depends on the frequency of use and the amount used. Thus, more frequent use or larger amounts of vaginal estrogens can have effects throughout the body (see conjugated estrogens, Premarin). The Women's Health Initiative found that postmenopausal women (50-79 years old) taking conjugated estrogens had an increased risk of breast cancer, blood clots, and stroke. There was also an increased risk of impaired cognition and/or dementia among women over age 65.
What is the dosage for Premarin cream?
The recommended dose is 0.5 to 2 grams administered daily for 21 days then off for 7 days. Twice weekly administration may also be used. Vaginal products work best if used at bedtime. The hands should first be washed and the applicator filled with cream from the tube. Lying on the back with the knees bent, individuals should insert the applicator into the vagina and push the applicator's plunger to deliver the cream. The applicator and plunger then should be washed with warm, soapy water and rinsed with plain water. The hands should be washed before and after use. A small amount of the cream also can be applied to the outer skin folds or "lips" of the vagina (vulvae) to relieve dryness or irritation.
Which drugs or supplements interact with Premarin cream?
Premarin drug interaction studies have not been conducted. Estrogens are broken down in the liver by certain enzymes. Drugs that increase or decrease the activity of these enzymes may interfere with the action of Premarin. Rifampin (Rifadin), barbiturates, carbamazepine (Tegretol), griseofulvin (Grifulvin), phenytoin (Dilantin), St. John's wort, and primidone may increase the elimination of estrogen by enhancing the liver's ability to eliminate estrogens. Use of any of these medications with estrogens may result in a reduction of the beneficial effects of estrogens. Conversely, drugs such as erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), and ritonavir (Norvir) may reduce the elimination of estrogens by the liver and lead to increased levels of estrogens in the blood and increased effects. Grapefruit juice also may increase levels of estrogen by increasing the absorption of estrogens from the intestine. Increased levels of estrogens in the blood may result in more estrogen-related side effects.
Is Premarin cream safe to take if I'm pregnant or breastfeeding?
Estrogens should be avoided during pregnancy since they increase the risk of fetal abnormalities.
Estrogens are secreted in milk and cause unpredictable effects in the infant. In general, they should not be used by women who are breastfeeding.
What else should I know about Premarin cream?
What preparations of Premarin cream are available?
How should I keep Premarin stored?
The cream should be stored at room temperature, 15-30 C (59-86 F).
- The Predicted 'Tripledemic' Is Here: Why Isn't There an RSV Vaccine?
- 'Tumor Progressing,' 'Positive Findings': Patients Often Confused by Medical Jargon
- Seizures Seem Tied to Faster Decline in People With Dementia
- Few Americans Understand Alcohol's Impact on Cancer Risk: Survey
- Frozen Stuffed Chicken Products & Microwave Ovens: A Recipe for Salmonella
- More Health News »
Conjugated estrogens vaginal cream (Premarin Vaginal Cream) is prescribed for the relief of vaginal symptoms in postmenoausal women who have vaginal dryness, inflammation, or painful intercourse due to atrophy of the vagina and vulva. Side effects, drug interactions, dosing, and pregnancy safety should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Menopause & Perimenopause: Symptoms, Signs
What is menopause? What are the signs of menopause? What age does menopause start? Learn about menopause and perimenopause...
Women's Health: 25 Hormone Imbalance Symptoms and Signs
Hormone imbalance involves changes in estrogen, progesterone, and other hormone levels. Hormonal imbalance in women may cause...
Menopause Quiz: Symptoms & Signs
The Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many...
Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms and signs include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies and should be discussed with your physician.
How Many Days Before a Period Do You Get Discharge?
Vaginal discharge is a normal part of a woman's menstrual cycle. Learn about vaginal discharge before a period, how many days you get discharge before your period, signs and causes of vaginal discharge, and when to see a doctor if there's a problem. Vaginal discharge is the fluid secreted from the uterus, cervix (neck of the uterus) and vagina. A thick yellow vaginal discharge may point to vaginitis (infection of the vagina).
Kidney Infection (Pyelonephritis)
Kidney infection (pyelonephritis) usually is caused by E. coli and other bacteria that have spread from the bladder from a UTI (urinary tract infection), poor hygiene, sexual intercourse, pregnancy, catheter, cystoscope exam, surgery, kidney stones, or prostate enlargement. Symptoms of kidney infection include back pain, frequent urination, pain during urination, fever, and or pus or blood in the urine. Kidney infection can be cured with antibiotic treatment. Cranberry juice may prevent UTIs, but that hasn’t been proven in all research studies.
Perimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop symptoms of declining estrogen levels that may include mood swings, painful sex, night sweats, hot flashes, and weight gain. Every adult woman eventually will experience perimenopause.
What Are the Benefits of Taking Estrogen?
Estrogen therapy, also known as hormone replacement therapy, is a treatment for alleviating the symptoms caused by menopausal transition. Estrogen therapy can alleviate symptoms like hot flashes, painful intercourse and bone loss.
Vaginal Dryness and Vaginal Atrophy
Vaginal dryness and vaginal atrophy occurs in women during perimenopause, menopause, and postmenopause. With vaginal atrophy, the lining of the vaginal wall becomes thinner, drier, less elastic, and light pink to bluish in color. Symptoms of vaginal atrophy include vaginal dryness, itching, irritation, and/or pain during intercourse. Treatment options for vaginal dryness and vaginal atrophy include hormone treatment and over-the-counter vaginal lubricating and moisturizing products.
Sex and Menopause
Menopause is often associated with a change in sexual functioning. Loss of estrogen, bladder control issues, anxiety, stress, health concerns, medications, and sleep disturbances often result in a decrease in libido. Though there are currently no good drugs for treating sexual problems in women, there are ways to increase intimacy with a partner and treat vaginal dryness.
Sexual health information including birth control, impotence, herpes, sexually transmitted diseases, staying healthy, women's sexual health concerns, and men's sexual health concerns. Learn about the most common sexual conditions affecting men and women.
Treatment & Diagnosis
- Menopause FAQs
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.