What is ColciGel, and how does it work?
ColciGel (colchicinum 4X) transdermal gel is an alkaloid indicated for treatment and prophylaxis of gout flares in adults. ColciGel is not an analgesic medication and should not be used to treat pain from other causes.
What are the side effects of ColciGel?
Common side effects of ColciGel include:
- mild skin irritation at the site of application
What drugs interact with ColciGel?
- ColciGel (Colchicinum 4X) is a substrate of the efflux transporter P-glycoprotein (P-gp).
- Of the cytochrome P450 enzymes tested, CYP3A4 was mainly involved in the metabolism of colchicinum.
- If ORAL colchicine is administered with drugs that inhibit P-gp, most of which also inhibit CYP3A4, increased concentrations of colchicinum are likely.
- Fatal drug interactions have been reported.
- Topical application of ColciGel has demonstrated insignificant systemic absorption in animal testing and confirmed in limited human pharmacokinetic evaluations and, therefore, poses a limited risk of clinically significant drug interactions.
- Physicians should, however, ensure that patients are suitable candidates for treatment with ColciGel and remain alert for signs and symptoms of toxicities related to increased colchicinum exposure as a result of a drug interaction.
- Signs and symptoms of ColciGel toxicity should be evaluated promptly and, if toxicity is suspected, ColciGel should be discontinued immediately.
Is ColciGel safe to use while pregnant or breastfeeding?
ColciGel (colchicinum 4X) transdermal gel is an alkaloid indicated for treatment and prophylaxis of gout flares in adults. ColciGel is not an analgesic medication and should not be used to treat pain from other causes. Common side effects of ColciGel include mild skin irritation at the site of application.
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Related Disease Conditions
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
What Foods Get Rid of Gout?
A gout diet may help decrease uric acid levels in the blood. A gout diet isn't a cure. But it may lower the risk of recurring gout attacks and slow the progression of joint damage.
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