- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: coenzyme Q10
Brand and Other Names: CoQ10, ibedenone, mitoquinone, ubidecarenone, ubiquinone, vitamin Q10
Drug Class: Herbals
What is coenzyme Q10, and what is it used for?
Coenzyme Q10 is a fat-soluble compound found in virtually all the cell membranes in the body, and in the highest concentrations in the heart, liver, kidneys and pancreas. Coenzyme Q10 is a member of the ubiquinone family of compounds that is naturally synthesized in the body. It is also available from dietary sources such as fatty fish, organ meats, poultry, eggs, vegetable oils, whole grains, nuts, legumes, and certain fruits and vegetables.
Coenzyme Q10 is taken as a dietary supplement to reduce symptoms and improve outcomes in many cardiovascular conditions including congestive heart failure, heart attack (myocardial infarction), chest pain (angina), and high blood pressure (hypertension), and many other conditions such as mitochondrial diseases, muscular dystrophies, and statin-induced muscle pain (myalgia). Coenzyme Q10 may also be taken to supplement natural deficiency due to primary coenzyme Q10 deficiency, a rare genetic disorder, or secondary deficiency.
Coenzyme Q10 plays a vital role in the transfer of protons and electrons in mitochondria and lysosomes. Mitochondria are intracellular organelles which convert carbohydrates and fats into adenosine triphosphate (ATP), the form of energy cells can use. Lysosomes in the cells contain the digestive enzymes that break down cellular debris. Coenzyme Q10 is also an antioxidant that prevents cellular damage from oxidative stress caused by reactive oxygen species (ROS), also known as free radicals.
The suggested uses of coenzyme Q10 include:
- Cardiovascular conditions such as:
- Chronic fatigue syndrome
- To boost the immune system in human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS)
- Diabetes mellitus
- Mitochondrial diseases
- Mitochondrial encephalomyopathy, an inherited disorder that affects multiple systems including the brain, nervous system and muscles
- Muscle wasting diseases (muscular dystrophies)
- Primary coenzyme Q10 deficiency
- Secondary coenzyme Q10 deficiency
- Muscle pain associated with statin use
- Gum (periodontal) disease
- To prevent plaque formation (atherosclerosis) in arteries
- To delay aging and improve age-related decline in vitality and energy
Clinical studies show some evidence that coenzyme Q10 use may be beneficial in some of the above conditions, particularly in the prevention of damage to the heart from heart disease or surgery and primary coenzyme Q10 insufficiency, however, there is inconclusive evidence for its efficacy in most of the conditions.
Research is ongoing (orphan designation) on the use of Coenzyme Q10, in conditions that include the following:
- Huntington’s disease
- Mitochondrial cytopathies
- Pediatric congestive heart failure
- Epidermolysis bullosa
Use coenzyme Q10 with caution in the following circumstances:
What are the side effects of coenzyme Q10?
Side effects of coenzyme Q10 include:
- Abdominal discomfort
- Reduced appetite
- Allergic skin rashes
- Elevated liver function test results
- Lowering of blood pressure
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
What are the dosages of coenzyme Q10?
There is no established standard dose of coenzyme Q10. Different supplement brands might have different ingredients and strengths. Follow directions on product labels and consult a healthcare professional before using.
- 50-200 mg orally daily
- Congestive heart failure (CHF): 100 mg/day divided two to three times daily orally
- Myocardial preservation for heart surgery: 200 mg/day orally
- Published studies indicate that coenzyme Q10 has low toxicity and does not induce serious adverse effects.
- In case of overdose, any adverse effects may be treated with symptomatic and supportive care.
What drugs interact with coenzyme Q10?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Coenzyme Q10 has no known severe or serious interactions with other drugs.
- Moderate interaction of coenzyme Q10 include:
- Mild interactions of coenzyme Q10 include:
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
What else should I know about coenzyme Q10?
- In general, coenzyme Q10 appears safe and well tolerated by most people
- Consult with your healthcare provide before taking coenzyme Q10 because of its potential side effects and interactions with certain medications
- Coenzyme Q10 is marketed as an herbal supplement and is not stringently regulated by the FDA like prescription drugs; products may differ in formulations and strengths; exercise caution in choosing your product
Latest Heart News
Daily Health News
Coenzyme Q10 is a nutrient and dietary supplement used to reduce symptoms and improve outcomes in many cardiovascular conditions including congestive heart failure, heart attack (myocardial infarction), chest pain (angina) and high blood pressure (hypertension), and many other conditions such as mitochondrial diseases, muscular dystrophies and statin-induced muscle pain (myalgia). Side effects of coenzyme Q10 include nausea, vomiting, diarrhea, heartburn, abdominal discomfort, reduced appetite, allergic skin rashes, elevated liver function test results, and lowering of blood pressure. Do not take if breastfeeding.
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Second Source article from WebMD
Second Source article from Government
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Second Source WebMD Medical Reference
Second Source article from Government
Second Source WebMD Medical Reference
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Myofascial Pain Syndrome Vs Fibromyalgia
Most people with chronic pain and fatigue in their muscles tend to have either fibromyalgia or myofascial pain syndrome (MPS). Fibromyalgia is a condition characterized by widespread musculoskeletal (involving the muscles and bones) pain accompanied by fatigue, sleep, memory, and mood issues.
Preeclampsia (Pregnancy Induced Hypertension)
Preeclampsia is related to increased blood pressure and protein in the mother's urine. Preeclampsia typically begins after the 20th week of pregnancy. When preeclampsia causes seizures, it is termed "eclampsia" and is the second leading cause of maternal death of in the US. Preeclampsia is the leading cause of fetal complications. Risk factors for preeclampsia include high blood pressure, obesity, multiple births, and women with preexisting medical conditions such as diabetes, kidney disease, rheumatoid arthritis, lupus, or scleroderma. Pregnancy planning and lifestyle changes may reduce the risk of preeclampsia during pregnancy.
What Is Muscular Dystrophy?
There are more than 30 types of muscular dystrophy that cause progressive muscle weakness, including Duchenne Becker (DMD), Becker (BMD), and more. Muscular dystrophy symptoms also include scoliosis (sideways curved spine), difficulty in walking or running, dysphagia (difficulty swallowing), muscle pain, breathing problems, and others.
How Do You Strengthen Your Heart After Heart Failure?
You can strengthen your heart after heart failure by making recommended changes to your diet, exercising regularly, and adopting healthy habits.
Does Fibromyalgia Qualify You for Medical Marijuana?
Whether fibromyalgia qualifies for medical marijuana depends on your state’s regulations.
What Foods Are Good to Treat Heart Failure?
If you have mild-to-moderate heart failure, you may lead a nearly normal life by making some lifestyle changes. Foods that are good to treat heart failure include fruits, vegetables, whole grains, low-fat protein, nuts, legumes, and unsaturated fats.
Is Irritable Bowel Syndrome Part of Fibromyalgia?
Yes, they are associated with each other. Fibromyalgia is linked with several different conditions, including IBS. IBS is also linked to other conditions that are not fibromyalgia.
High Blood Pressure Symptoms
Most people with high blood pressure have no signs or symptoms, even if blood pressure readings reach dangerously high levels. In some patients, symptoms may include fatigue, headaches, dizziness, confusion, sweating, chest pain and vision problems.
What Are Usually the First Signs of Muscular Dystrophy?
Depending on the type of muscular dystrophy, initial symptoms may include muscle weakness, difficulty walking, frequent falls, limited movement, and more.
Fibromyalgia: Treatment, Symptoms & Causes
Fibromyalgia is a common neurologic health problem that causes widespread pain and tenderness in the body. It is accompanied by fatigue, disturbances in thought and memory, low moods, and extreme anxiety about the physical symptoms.
What Is the Proper Way to Take Your Blood Pressure?
Nowadays, you can easily measure your blood pressure at home using an automated blood pressure machine or sphygmomanometer. Here’s how to do it step-by-step to make sure you’re doing it the right way.
Can People With Fibromyalgia Live Normal Lives?
People with fibromyalgia can live a normal and active life if they have the support of a physician.
Can Angina Lead to a Heart Attack?
Angina, or angina pectoris, is a sudden chest pain caused by low blood flow to the heart. Yes, some types of angina attacks can lead to heart complications.
Hypertension-Induced Chronic Kidney Disease
Hypertension-induced chronic kidney disease (CKD) is a long-standing kidney condition that develops over time due to persistent or uncontrolled high blood pressure (hypertension).
How Does High Blood Pressure Affect Pregnancy?
High blood pressure during pregnancy can cause serious complications. Learn more about the signs of and risks associated with the condition.
What Is a Normal Blood Pressure Check?
A normal blood pressure check should be below 120/80 mmHg in adults (18 years and older).
What Is the Drug of Choice for Hypertension?
Angiotensin-converting enzyme (ACE) inhibitors are the drug of choice for hypertension. Learn about other high blood pressure medications.
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause of heart failure. The process of developing atherosclerosis (hardening of the arteries) begins early in life. Heart attack prevention should begin in childhood because the atherosclerosis process can not be reversed. The risk of having a heart attack increases if you have diseases or conditions such as high blood pressure, diabetes, and other heart conditions.
What Is High Blood Pressure (Hypertension)?
High blood pressure or hypertension is when the blood pressure readings consistently range from 140 or higher for systolic or 90 or higher for diastolic. Blood pressure readings above 180/120 mmHg are dangerously high and require immediate medical attention.
How Often Should Blood Pressure be Checked?
People older than 40 years should check their blood pressure once a year, while those between 18 and 40 years old should check it every three to five years.
Is Pseudotumor Cerebri the Same as Intracranial Hypertension?
Pseudotumor cerebri (PTC) is also called idiopathic intracranial hypertension (IIH). The condition causes symptoms similar to a brain tumor.
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are interconnected and affect your risk for heart disease or heart attack. For better heart health, avoid the following fried foods, hard margarine, commercial baked goods, most packaged and processed snack foods, high fat dairy, and processed meats such as bacon, sausage, and deli meats.
What Is a Widowmaker Heart Attack?
A Widowmaker is a type of heart attack, which is deadlier than most others. A widowmaker heart attack occurs when the left ascending artery (LAD) that supplies blood to the front part of the heart (largest part) is clogged-up because of clots in the arterial wall. This causes the death of heart muscle in this area, medically termed myocardial infarction. Because the widowmaker damages a major portion of the heart, timely management is necessary to prevent fatalities.
Can Kawasaki Disease Cause Heart Failure?
Approximately 50 percent of children with Kawasaki disease may develop inflammation of the heart muscle and potentially heart failure, in severe cases.
What Causes High Blood Pressure in Children?
Research states that kidney disease is the main cause of high blood pressure in children; however, here are the other potential causes of hypertension in kids.
Can You Have Sex Right After a Heart Attack?
It is important not to put any pressure on yourself or your heart after heart attack. Initially, you might feel less interested in sex. That is perfectly normal, and the feeling goes away quickly.
Muscular Dystrophy Types & Causes of Each Form
Muscular dystrophies are a group of genetic diseases causing progressive weakness and loss of muscle mass. There are more than 30 types of muscular dystrophy that result in muscle weakness. Over time, the muscles get weaker, disturbing the gait (a person’s manner of walking) and the ability to perform daily activities.
Can You Still Exercise With Heart Failure?
Performing light to moderate exercises is a great way to strengthen your heart muscles after being diagnosed with heart failure.
What Does a Sudden Heart Attack Feel Like?
In most cases, a sudden heart attack may feel like pain, pressure, fullness, or squeezing in the chest that lasts for a few minutes or goes away and comes back.
Treatment & Diagnosis
- Fibromyalgia FAQs
- High Blood Pressure FAQs
- Chest Pain FAQs
- Heart Failure FAQs
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- Heart Attack Risk and Medicated Stents
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