- What is clotrimazole, and how does it work (mechanism of action)?
- What are the uses for clotrimazole?
- What are the side effects of clotrimazole?
- What drugs or supplements interact with clotrimazole?
- What is the dosage for clotrimazole?
- Is clotrimazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about clotrimazole?
What is clotrimazole, and how does it work (mechanism of action)?
Clotrimazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Micatin, Monistat). It prevents growth of several types of fungi by preventing interfering with the production of the membrane that surrounds fungal cells. It is used topically on the skin, inserted vaginally or allowed to dissolve in the mouth for local fungal infections.
What brand names are available for clotrimazole?
- Lotrimin AF , Mycelex, Trivagizole
- Gyne-Lotrimin (DC), Alevazol, Desenex, Lotrimin have been discontinued.
Is clotrimazole available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for clotrimazole?
Yes, for some generic preparations. Lotrimin AF, Mycelex, and Trivagizole are over-the-counter preparations.
What are the uses for clotrimazole?
Clotrimazole is used for the treatment of local fungal infections due to Candida albicans, including the following:
What are the side effects of clotrimazole?
The most commonly noted side effects associated with clotrimazole include:
- local redness,
- hives, or
- burning at the area of application.
What is the dosage for clotrimazole?
The troche (lozenge) should slowly dissolve in the mouth. One troche is administered 5 times daily for 14 days. Clotrimazole cream, lotion, or solution is applied to the affected and surrounding skin areas, generally twice daily in the morning and evening.
The vaginal cream is inserted via applicator once daily, preferably at night, for 7 consecutive days.
The 100 mg vaginal suppository is inserted once daily, preferably at bedtime, for 7 consecutive days.
The 200 mg vaginal suppository is inserted once daily for 3 days, preferably at bedtime.
Latest Skin News
Daily Health News
Is clotrimazole safe to take if I'm pregnant or breastfeeding?
Clotrimazole is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters of pregnancy have demonstrated no ill effects. No data is available in pregnant women during their first trimester. Rats given large amounts of clotrimazole via the vagina have demonstrated no ill effects. The oral troche has not been adequately evaluated in pregnant women.
It is not known if clotrimazole is secreted in breast milk.
What else should I know about clotrimazole?
What preparations of clotrimazole are available?
- Topical cream, solution or lotion: 1%
- Buccal troche: 10 mg
- Vaginal suppositories: 100 and 200 mg
- Vaginal cream: 1% and 2%
How should I keep clotrimazole stored?
Cream, lotion, solution and troche should be stored between 20 C to 25 C (68 F to 77 F). Vaginal suppositories should be stored between 15 C to 30 C (59 F to 86 F).
IMAGESBrowse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies See Images
Clotrimazole, (Lotrimin AF, Mycelex, Trivagizole) is a drug prescribed to treat local fungal infections such as vaginal yeast infections, oral thrush, athlete's foot, and jock itch. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Fungal Skin Infections: Types, Symptoms, and Treatment
Fungal skin infections and fungal nail infections produce symptoms like red, itchy, circular rashes and thick, discolored, flaky...
Yeast Infection Quiz: Symptoms & Treatment
How much do you know about vaginal yeast infections? Learn the causes, symptoms, and treatments of a yeast infection with the...
Picture of Athlete's Foot 2
Athlete's foot is a fungus that causes itching, redness, and cracking. See a picture of Athlete's Foot and learn more about the...
Picture of Types of Ringworm
Ringworm is a common skin disorder otherwise known as tinea. See a picture of Types of Ringworm and learn more about the health...
Picture of Athlete's Foot 1
Athlete's foot is caused by a fungus that grows on or in the top layer of skin. See a picture of Athlete's Foot and learn more...
Related Disease Conditions
Jock itch is an itchy red rash that appears in the groin area. The rash may be caused by a bacterial or fungal infection. People with diabetes and those who are obese are more susceptible to developing jock itch. Antifungal shampoos, creams, and pills may be needed to treat fungal jock itch. Bacterial jock itch may be treated with antibacterial soaps and topical and oral antibiotics.
Thrush (Oral Candidiasis)
Thrush is an infection of the mouth caused by the Candida fungus. Symptoms of thrush include pain or difficulty swallowing, a feeling that food gets stuck in the throat, and fever.
Athlete's foot (tinea pedis) is a skin infection caused by the ringworm fungus. Symptoms include itching, burning, cracking, peeling, and bleeding feet. Treatment involves keeping the feet dry and clean, wearing shoes that can breathe, and using medicated powders to keep your feet dry.
The term "ringworm" refers to a fungal infection on the surface of the skin. A physical examination of the affected skin, evaluation of skin scrapings under the microscope, and culture tests can help doctors make the appropriate distinctions. A proper diagnosis is essential to successful treatment. The different types of ringworm include the following: tinea barbae, tinea capitis, tinea corporis, tinea cruris, tinea faciei, tinea manus, tinea pedis, and tinea unguium.
Vaginal Yeast Infection in Women
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Is Ringworm Contagious?
A fungus causes ringworm. Ringworm can be transmitted from person to person. Animals may also spread ringworm. Ringworm causes an itchy, ring-shaped red rash with hair loss. Treatment incorporates the use of topical medication.
Sickle Cell Disease (Anemia)
Sickle cell anemia (sickle cell disease), a blood disease which shortens life expectancy, is caused by an inherited abnormal hemoglobin. Symptoms of sickle cell anemia may include bacterial infections, painful swelling of the hands and feet, fever, leg ulcers, fatigue, anemia, eye damage, and lung and heart injury. Treatment for sickle cell anemia aims to manage and prevent the worst manifestations of the disease and focuses on therapies that block red blood cells from stacking together, which can lead to tissue and organ damage and pain.
Dandruff (seborrhea) is a skin disorder that results from neither too much moisture nor too much oil. Dandruff can be treated with shampoos that contain tar, salicylic acid, zinc, selenium sulfide, or ketoconazole.
Oral Thrush in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
Tinea versicolor is a fungus infection that mainly affects the skin of young people. Recognized by light or reddish brown spots, and areas lighter than the surrounding skin. Tinea versicolor is caused by yeast actually found in our skin. Factors like heat, humidity, and sweat help it proliferate in people, resulting in a rash that is not contagious to others.
Ringworm vs. Eczema
While ringworm is a fungal infection, and eczema is a skin condition, both are characterized by itchiness. Eczema patches are leathery while ringworm involves ring formation on the skin. Over-the-counter antifungals treat ringworm. Topical creams and ointments treat eczema.
Treatment & Diagnosis
- Yeast Infection FAQs
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Lamisil (terbinafine) vs. Lotrimin (clotrimazole)
- Which Antibiotic Is Best for An Ear Infection?
- Diflucan (fluconazole)
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- itraconazole, Sporanox
- ketoconazole, Nizoral, Extina, Xolegel, Kuric
- Vfend (voriconazole)
- Ertaczo (sertaconazole nitrate) Cream
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.