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- What is clonidine, and how does it work?
- What are the approved uses for clonidine?
- What are the FDA non-approved (off-label) uses for clonidine?
- What are the side effects of clonidine?
- What is the dosage for clonidine?
- Which drugs or supplements interact with clonidine?
- Is clonidine safe to use during pregnancy or while breastfeeding?
- What else should I know about clonidine?
What is clonidine, and how does it work?
- Clonidine (Catapres, Catapres-TTS) is an oral and topical (applied to the skin) medication prescribed by a doctor for the treatment of high blood pressure (hypertension). It acts by stimulating receptors on nerves in the brain that reduces the transmission of messages from nerves in the brain to nerves in other areas of the body. As a result, it slows heart rate and reduces blood pressure.
- The FDA approved clonidine in September 1974.
What brand names are available for clonidine?
- Catapres,Catapres-TTS, and Kapvay are the brand names for this drug available in the U.S. for the treatment of high blood pressure.
- The brand Jenloga has been discontinued in the U.S.
Is clonidine available as a generic drug?
- There are generic versions of the tablets and patch.
Do I need a prescription for clonidine?
- Yes, a prescription by doctor or health care professional is necessary for this drug.
What are the approved uses for clonidine?
- Clonidine is approved for the treatment of high blood pressure. It may be used alone or combined with other drugs used for the treatment of high blood pressure.
- Clonidine is also used off-label for the treatment of alcohol withdrawal, smoking cessation, restless leg syndrome, Tourette’s syndrome, and opioid withdrawal.
What are the FDA non-approved (off-label) uses for clonidine?
Non-FDA approved (off-label) uses for this medication include the treatment of:
- Symptoms of narcotic withdrawal
- Nicotine withdrawal
- Diabetes-associated diarrhea
- Diabetic neuropathy (nerve damage)
- Hot flashes associated with menopause
- Alcohol withdrawal
- Smoking cessation
- Restless leg syndrome
- Tourette’s syndrome
What are the side effects of clonidine?
The most common side effects are:
Other side effects include:
Possible serious side effects include:
- Severe rebound high blood pressure
- Severe low blood pressure
- Slow heart rate
- Withdrawal symptoms
- Severe allergic reactions
- Slow heart rate
- Abnormal heart conduction
Severe rebound hypertension can occur following withdrawal from clonidine. This reaction is more likely to occur if clonidine is stopped suddenly (without a gradual dose reduction).
Symptoms of severe rebound high blood pressure can include:
- Increased salivation
- Heart palpitations
- Muscle pain
- Abdominal pain
Slowly reducing the dose of this medication over several days will prevent these symptoms.
What is the dosage for clonidine?
- The usual oral adult dose is 0.1–0.3 mg twice daily.
- The maximum oral dose is 2.4 mg daily.
- Topical patches should be applied to an area of hairless skin on the upper arm or torso, once every 7 days.
- When applying a new topical patch, a different area of skin should be used.
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Which drugs or supplements interact with clonidine?
This drug can increase the sedating effects of other medications that cause sedation. Such drugs include:
- Narcotic pain relievers
- Sedatives such as alprazolam (Xanax) and clonazepam (Klonopin)
Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep), imipramine (Tofranil), desipramine (Norpramin), and clomipramine (Anafranil), can block the blood pressure lowering effects of Catapres. This may cause blood pressure to rise.
Since this drug can reduce heart rate, it should be used cautiously in persons who are receiving any other medication that lowers heart rate such as beta-blockers, for example:
- atenolol (Tenormin)
- metoprolol (Lopressor)
- propranolol (Inderal)
- digoxin (Lanoxin)
- diltiazem (Cardizem)
- verapamil (Calan Covera HS)
Abnormal heart rhythms can occur with the combination of clonidine and verapamil.
Cocaine, pseudoephedrine, phenylephrine, and phenylpropanolamine also can reverse the blood pressure lowering effects of clonidine.
Is clonidine safe to use during pregnancy or while breastfeeding?
What else should I know about clonidine?
What preparations of clonidine are available?
- Tablets (immediate release): 0.1, 0.2, and 0.3 mg.
- Transdermal patches: 0.1, 0.2, and 0.3 mg delivered over 24 hours.
How should I keep clonidine stored?
- Tablets and patches should be kept at room temperature, 15 C - 30 C (59 F - 86 F).
Clonidine (Catapres, Catapres-TTS, Kapvay) is an oral and topical drug prescribed for the treatment of high blood pressure. Off label uses include the treatment of the symptoms of narcotic and nicotine withdrawal, diabetic neuropathy, hot flashes (associated with menopause), and cancer pain. Review side effects, warnings and precautions, drug interactions, and pregnancy and breastfeeding safety information prior to taking any medication.
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