- Tips to Fast Stress Relief
- Take the Panic Attacks Quiz!
- Generalized Anxiety Disorder (GAD) Slideshow
- What is clomipramine-oral, and how does it work (mechanism of action)?
- What brand names are available for clomipramine-oral?
- Is clomipramine-oral available as a generic drug?
- Do I need a prescription for clomipramine-oral?
- What are the side effects of clomipramine-oral?
- What is the dosage for clomipramine-oral?
- Which drugs or supplements interact with clomipramine-oral?
- Is clomipramine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about clomipramine-oral?
What is clomipramine-oral, and how does it work (mechanism of action)?
Clomipramine (Anafranil) is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs).
The exact mechanism by which clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.
What are the side effects of clomipramine-oral?
The most common side effects associated with the use of clomipramine include:
- upset stomach,
- dry mouth,
- sexual dysfunction,
- weight gain,
- low blood pressure,
- respiratory problems, and
- visual changes.
Less common but serious side effects include:
- hypersensitivity type reactions,
- suicidal ideation,
- serotonin syndrome, and
What is the dosage for clomipramine-oral?
: Treatment with clomipramine should be started at the lowest recommended dose and increased slowly based on patient response to minimize the risk for side effects. Clomipramine tablets are better tolerated when administered with meals.
Which drugs or supplements interact with clomipramine-oral?
Patients starting treatment with clomipramine should consult with their doctor or pharmacist to find out if any of their current medications or supplements have any drug interactions with clomipramine. Also, patients receiving treatment with clomipramine should always consult with their doctor before starting treatment with any new medications.
Clomipramine generally is not recommended to be used with other tricyclic antidepressants or related cyclic antidepressants. Co-administration with medications that share similar properties increases the risk for side effects. Examples of similar antidepressants are amoxapine, imipramine (Tofranil), and desipramine (Norpramin).
Clomipramine shares pharmacological properties with Class IA and Class III antiarrhythmic medications. Co-administration increases the risk for QT prolongation and life-threatening arrhythmias. For this reason, use of clomipramine should be avoided with bretylium, dofetilide (Tikosyn), dronedarone (Multaq), flecainide (Tambocor), sotalol (Betapace), quinidine (Quinidex), procainamide (Pronestyl), propafenone (Rythmol), ranolazine (Ranexa), ibutilide (Corvert), and others.
Clomipramine should be avoided when possible or used cautiously with medications known to prolong the QTc interval. Examples of such medication are thioridazine (Mellaril), ziprasidone (Geodon), pimozide (Orap), and others.
Clomipramine increases the levels of serotonin in the brain. Co-administration with other medications that also increase serotonin levels increases the risk of serotonin syndrome. Symptoms of serotonin syndrome include rapid development of hyperthermia (high body temperature), high blood pressure, muscle rigidity, confusion, and delirium. Some medications that increase serotonin levels are monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, and linezolid (Zyvox). For a complete list, please ask your doctor or pharmacist.
Is clomipramine-oral safe to take if I'm pregnant or breastfeeding?
Clomipramine has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, clomipramine should be used in pregnancy only if the benefit justifies the potential risk to the fetus. Clomipramine is classified as FDA pregnancy risk category C.
Clomipramine is excreted into breast milk. Due to the lack of safety data, clomipramine is not recommended for use in females who are breastfeeding.
What else should I know about clomipramine-oral?
What preparations of clomipramine-oral are available?
Oral tablets: 25, 50, and 75 mg.
How should I keep clomipramine-oral stored?
Tablets should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). As with all medications, clomipramine tablets should be kept out of the reach of children and pets.
Clomipramine (Anafranil) is a drug prescribed to treat OCD or obessive-compulsived disorder. Off-label (not approved by the FDA to treat these conditions) uses of clomipramine include the treatment patients with major depression, panic attacks, anxiety disorders, and premature ejaculation. Side effects, drug interactions, dosing, storage, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Depression Quiz: Signs & Symptoms
Many people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With...
Panic Attacks (Panic Disorder) Quiz: Test Your Mental Health IQ
Could you suffer a panic attack? Take this Panic Attacks Quiz to learn causes, symptoms, and treatments for panic disorder. Use...
Learn to Spot Depression: Symptoms, Warning Signs, Medication
What is depression? Get information on symptoms, signs, tests, and treatments for many types of depression including major...
Anxiety Disorder Pictures: Symptoms, Panic Attacks, and More with Pictures
Learn about generalized anxiety disorder (GAD). See if your worries are normal or something more by learning about symptoms,...
Premenstrual Syndrome (PMS): Track and Prevent Symptoms
Premenstrual Syndrome (PMS) can cause from mood swings, munchies, and more. Learn about the symptoms, causes and treatments of...
Better Sex After 50
It's never too late to improve your sex life. Learn how to overcome common health conditions affecting those over 50 such as...
Physical Symptoms of Depression in Pictures
Depression can cause physical problems such as insomnia, chest pain, fatigue, headaches, and more. Learn the signs of depression...
Depression Tips: Exercise, Diet, Stress Reduction, and More in Pictures
The right exercise, diet, and activities -- even playing with a pet --can help you recover from depression. Learn simple...
Sex Tips for Men: How to Have a Better Sex Life
Learn sex tips for men that lead to more sexual pleasure such as better communication, focusing on pleasurable sensations,...
Depression Myths: Overwork, Recklessness and More in Pictures
Explore the myths and facts about depression. See how folk remedies and half-truths still prevent many from getting treatment for...
Healthy Aging: Sneaky Depression Triggers in Pictures
There are many causes and triggers of depression. From too little vitamin B12 to too much time alone, look at these surprising...
Postpartum Depression: Symptoms, Diagnosis and Treatment
Postpartum depression is a treatable medical illness which affects women after giving birth. Learn about the symptoms, diagnosis...
Depression Therapy: Myths, Facts, and More in Pictures
False ideas scare many depression suffers away from therapy and the quick relief and help these pros can provide. Let our experts...
Related Disease Conditions
Sexual Problems in Men
Male sexual dysfunction can be caused by physical or psychological problems. Common sexual problems in men include erectile...
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems,...
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one...
The term sex addiction describes the behavior of someone who has an unusually strong sex drive or sexual obsession. Sex and...
Panic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep....
Depression in Children
Childhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include...
Tourette syndrome is disorder, which symptoms include involuntary facial tics, motor tics, and vocal tics. The cause of Tourette...
Depression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior,...
Compulsive gambling is a disorder that affects millions in the U.S. Symptoms and signs include a preoccupation with gambling,...
Separation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults...
Obsessive Compulsive Disorder (OCD)
Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions....
Dysthymia is a less severe form of chronic depression. Symptoms and signs include insomnia, suicidal thoughts, guilt, empty...
Postpartum depression is a form of depression that occurs within a year after delivery. It is thought that rapid hormone changes...
Holiday Depression, Anxiety, and Stress
Though the holidays are a fun time for most, for others, they're a sad, lonely and anxiety-filled time. Get tips on how to avoid...
Depression in the Elderly
Depression in the elderly is very common. That doesn't mean, though, it's normal. Treatment may involve antidepressants,...
Treatment & Diagnosis
Medications & Supplements
Daily Health News
Subscribe to MedicineNet's Depression Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top clomipramine-oral Related Articles
AnxietyAnxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
DepressionDepression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Depression in ChildrenChildhood depression can interfere with social activities, interests, schoolwork and family life. Symptoms and signs include anger, social withdrawal, vocal outbursts, fatigue, physical complaints, and thoughts of suicide. Treatment may involve psychotherapy and medication.
Depression SlideshowWhat is depression? Get information on symptoms, signs, tests, and treatments for many types of depression including major depression, chronic depression, teen depression, and postpartum depression.
Depression QuizMany people do not recognize the symptoms and warning signs of depression and depressive disorders in children and adults. With proper diagnosis, treatments and medications are available. Take this quiz to learn more about recovery from depression.
Gambling AddictionCompulsive gambling is a disorder that affects millions in the U.S. Symptoms and signs include a preoccupation with gambling, lying to family or loved ones to hide gambling, committing crimes to finance gambling, and risking importance relationships and employment due to gambling. Treatment may incorporate participation in Gamblers' Anonymous, psychotherapy, and medications like carbamazepine, topiramate, lithium, naltrexone, antidepressants, clomipramine, and fluvoxamine.
Anxiety SlideshowLearn about generalized anxiety disorder (GAD). See if your worries are normal or something more by learning about symptoms, diagnosis, and treatments of anxiety disorders.
Panic Attacks QuizCould you suffer a panic attack? Take this Panic Attacks Quiz to learn causes, symptoms, and treatments for panic disorder. Use this quiz to learn to recognize the main elements of this serious, yet common disorder known as panic attacks.
Panic DisorderPanic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep. A person experiencing a panic attack may believe that he or she is having a heart attack or that death is imminent. The fear and terror that a person experiences during a panic attack are not in proportion to the true situation and may be unrelated to what is happening around them. Most people with panic attacks experience several of the following symptoms: racing heartbeat, faintness, dizziness, numbness or tingling in the hands and fingers, chills, chest pains, difficulty breathing, and a feeling of loss or control. There are several treatments for panic attacks.
PMS SlideshowPremenstrual Syndrome (PMS) can cause from mood swings, munchies, and more. Learn about the symptoms, causes and treatments of PMS.
Seniors Sex ProblemsIt's never too late to improve your sex life. Learn how to overcome common health conditions affecting those over 50 such as heart disease, diabetes, and arthritis in order to have a healthy sex life.
Separation AnxietySeparation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults can suffer from symptoms of separation anxiety disorder. Common separation anxiety treatment methods include therapy and medications. Factors that contribute to how quickly or successfully a child moves past separation anxiety by preschool age include:
- how well the parent and child reunite,
- the skills the child and adult have at coping with the separation, and
- how well the adult responds to the infant's separation issues.
Sexual (Sex) Problems in MenMale sexual dysfunction can be caused by physical or psychological problems. Common sexual problems in men include erectile dysfunction (impotence or ED), premature ejaculation, and loss of libido. Treatment for sexual dysfunction in men may involve medication, hormone therapy, psychological therapy, and the use of mechanical aids.
Sexual AddictionThe term sex addiction describes the behavior of someone who has an unusually strong sex drive or sexual obsession. Sex and thoughts of sex dominate a sex addict's thinking, making it difficult to work or engage in healthy personal relationships. Sex addicts may engage in exhibitionism, voyeurism, prostitution, compulsive masturbation, or cybersex. Treatment for sex addiction includes individual counseling, marital and/or family therapy, support groups, 12-step recovery programs, and in some cases, medications.
Teen DepressionDepression in teenagers may be caused by many factors. Symptoms of teen depression include apathy, irresponsible behavior, sadness, sudden drop in grades, withdrawal from friends, and alcohol and drug use. Treatment of depression in adolescents may involve psychotherapy and medications.
Tourette SyndromeTourette syndrome is disorder, which symptoms include involuntary facial tics, motor tics, and vocal tics. The cause of Tourette syndrome is not known. ADHD is associated with Tourette syndrome. Treatment includes medication, psychotherapy, and in severe cases surgery.