Clomiphene is an oral medication used for stimulating ovulation. It binds to estrogen receptors in the hypothalamus, pituitary gland, ovary, endometrium, vagina, and cervix. It causes production of hormones (gonadotropins) by the pituitary which stimulates ovulation. The FDA approved clomiphene in February 1967.

Serophene

GENERIC AVAILABLE: Yes

Yes

The most common side effects of clomiphene are:

• ovarian enlargement,
• flushing,
• stomach discomfort,
• breast discomfort,
• blurred vision,
• nausea, and
• vomiting.

Other important side effects include

• abnormal heart beats,
• acne,
• allergic reactions,
• headaches,
• uterine bleeding,
• back pain, and
• muscle pain.

The recommended dose is 50 to 100 mg orally for 5 days. The initial dose is 50 mg which may be increased to 100 mg if there is no response. Dosage may be repeated as early as 30 days after the previous treatment.

: No drug interactions are listed in the prescribing information.

Clomiphene should not be taken by pregnant women since it does not offer any benefit to pregnant women.

NURSING MOTHERS: It is not known whether clomiphene is excreted into breast milk. It may reduce lactation in some women.

What preparations of clomiphene-oral are available?

Tablets: 50 mg

How should I keep clomiphene-oral stored?

Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).