clindamycin vaginal cream (Cleocin, Clindesse)

What is clindamycin phosphate-vaginal cream, and how does it work (mechanism of action)?

Clindamycin is an antibiotic used for treating serious infections. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin for vaginal use in August 1972.

What brand names are available for clindamycin phosphate-vaginal cream?

Cleocin, Clindesse

Is clindamycin phosphate-vaginal cream available as a generic drug?


Do I need a prescription for clindamycin phosphate-vaginal cream?


What are the side effects of clindamycin phosphate-vaginal cream?

The most common side effects of clindamycin cream are:

What is the dosage for clindamycin phosphate-vaginal cream?

The recommended dose is one full applicator of clindamycin phosphate vaginal cream 2% intravaginally, preferably at bedtime, for 3 or 7 days in non-pregnant women and for 7 days in pregnant women.

Which drugs or supplements interact with clindamycin phosphate-vaginal cream?

Clindamycin give orally may act as a neuromuscular blocker. This means that it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium). However, very little clindamycin is absorbed into the blood stream when given vaginally so the likelihood of drug interactions is less.


The vagina includes the labia, clitoris, and uterus. See Answer

Is clindamycin phosphate-vaginal cream safe to take if I'm pregnant or breastfeeding?

The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters, and clindamycin vaginal cream is approved for use during the second and third trimesters of pregnancy. Clindamycin should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester.

Oral clindamycin is excreted in breast milk and should not be used by nursing mothers, or nursing should be stopped. It is not known whether clindamycin given vaginally is excreted in breast milk.

What else should I know about clindamycin phosphate-vaginal cream?

What preparations of clindamycin phosphate-vaginal cream are available?

Cream: 2%

STORAGE: Clindamycin should be stored at room temperature 20 C to 25 C (68 F to 77 F).


Clindamycin phosphate vaginal cream (Cleocin) is used to treat symptoms of bacterial vaginosis. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to using this medication.

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Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine


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