clindamycin phosphate vaginal suppository

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is clindamycin-vaginal suppository, and how does it work (mechanism of action)?

Clindamycin is an antibiotic used for treating several infections. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin vaginal suppositories in November, 2004.

What brand names are available for clindamycin-vaginal suppository?


Is clindamycin-vaginal suppository available as a generic drug?


Do I need a prescription for clindamycin-vaginal suppository?


What are the side effects of clindamycin-vaginal suppository?

The most common side effects of clindamycin vaginal suppositories are:

Other side effects that may occur include:

Possible serious side effects of clindamycin include:

  • Orally administered and injected clindamycin may cause severe colitis (inflammation of the colon).
  • Vaginal formulations of clindamycin may be absorbed into the blood stream, and colitis with diarrhea or bloody diarrhea (including C.difficile colitis) have been reported with the use of clindamycin vaginal suppositories.

What is the dosage for clindamycin-vaginal suppository?

  • Insert 1 suppository into the vagina at night for 3 days.
  • Patients should avoid vaginal intercourse or vaginal products (such as tampons or douches) during treatment with clindamycin vaginal suppositories.

Is clindamycin-vaginal suppository safe to take if I'm pregnant or breastfeeding?

  • The frequency of congenital abnormalities was not increased when pregnant women used oral clindamycin during the second and third trimesters.
  • Pregnant women who used clindamycin vaginal cream during the second trimester reported abnormal labor more frequently than those who received placebo.
  • Clindamycin vaginal suppositories have not been properly evaluated during the first trimester of pregnancy. They should only be used during the first trimester of pregnancy when they are clearly needed.
  • Oral clindamycin is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.
  • It is not known whether clindamycin from vaginal suppositories is excreted in breast milk.

What else should I know about clindamycin-vaginal suppository?

What preparations of clindamycin-vaginal suppository are available?

  • Suppositories: 100 mg

How should I keep clindamycin-vaginal suppository stored?

  • Clindamycin vaginal suppositories should be stored at room temperature, 15 C – 30 C (59 F – 86 F).


Clindamycin phosphate vaginal suppository (Cleocin) is an antibiotic prescribed to treat bacterial vaginosis infection in women. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to using this medication.

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REFERENCE: FDA Prescribing Information.