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- What is ciprofloxacin-ophthalmic drops, and how does it work (mechanism of action)?
- What brand names are available for ciprofloxacin-ophthalmic drops?
- Is ciprofloxacin-ophthalmic drops available as a generic drug?
- Do I need a prescription for ciprofloxacin-ophthalmic drops?
- What are the side effects of ciprofloxacin-ophthalmic drops?
- What is the dosage for ciprofloxacin-ophthalmic drops?
- Which drugs or supplements interact with ciprofloxacin-ophthalmic drops?
- Is ciprofloxacin-ophthalmic drops safe to take if I'm pregnant or breastfeeding?
- What else should I know about ciprofloxacin-ophthalmic drops?
What is ciprofloxacin-ophthalmic drops, and how does it work (mechanism of action)?
Ciprofloxacin is an antibiotic that is used to treat bacterial infections. Ciprofloxacin belongs to the fluoroquinolone class of antibiotics which includes levofloxacin (Levaquin), ofloxacin (Floxin), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), and others. Ciprofloxacin interferes with bacterial DNA uncoiling and replication, which ultimately leads to bacterial cell death. Ciprofloxacin, like other fluoroquinolone antibiotics, targets a wide range of bacteria. Targeted organisms include Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and the viridans group of Streptococcus. Ciprofloxacin ophthalmic solution was approved in March 1998.
What are the side effects of ciprofloxacin-ophthalmic drops?
It is common to have white crust or crystals (precipitate) into the eye or on the eyelid during treatment; they dissolve in a few weeks. Other common side effects include:
- unpleasant taste in the mouth immediately after instilling the drop,
- discomfort of the eye,
- the sensation that something is in the eye.
The eye can also appear tired, stained, or swollen.
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What is the dosage for ciprofloxacin-ophthalmic drops?
The dose for bacterial eye infections in adults and children 1 year old or greater is 1 to 2 drops every 2 hours in the infected eye for 2 days, followed by 1-2 drops every 4 hours for 5 days. For corneal ulcers in this population, instill 2 drops into the eye every 15 minutes for 6 hours, followed by 2 drops every 30 minutes for the rest of day 1. On day 2, 2 drops should be used every hour, followed by 2 drops every 4 hours on days 3 to 14.
Which drugs or supplements interact with ciprofloxacin-ophthalmic drops?
There are no known significant drug interactions with ciprofloxacin ophthalmic solution.
Is ciprofloxacin-ophthalmic drops safe to take if I'm pregnant or breastfeeding?
Use during pregnancy has not been adequately evaluated. Ophthalmic use may lead to some systemic absorption, so caution should be used.
Oral and IV ciprofloxacin passes into breast milk. Ophthalmic use may lead to some absorption into the body, so caution should be used in nursing mothers.
What else should I know about ciprofloxacin-ophthalmic drops?
What preparations of ciprofloxacin-ophthalmic drops are available?
Ophthalmic Solution 0.3%
How should I keep ciprofloxacin-ophthalmic drops stored?
Ciprofloxacin solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F), or may be refrigerated and stored between 2 C to 8 C (36 F to 46 F). Protect from light.
REFERENCE: FDA Prescribing Information.
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Ciprofloxacin (generic name), Cipro, Cipro XR (brand names) is an antibiotic prescribed for the treatment of many skin, lung, airway, bone, and joint infections caused by susceptible bacteria. Examples include:
- Complicated urinary tract infections (UTIs)
- Chronic bacterial prostatitis
- Typhoid fever
- Chronic bronchitis
- Infectious diarrhea caused by E. coli, Shigella, and Campylobacter jejuni.
- Anthrax patients
- TB (tuberculosis)
Cipro should not be used for treating uncomplicated UTIs, acute bacterial chronic bronchitis, or acute bacterial sinusitis because of the serious side effects it may cause.
The FDA has issued a warning for fluoroquinolenes like Cipro because they have been associated with some serious adverse reactions, for example:
- Tendinitis or tendon rupture, particularly the Achilles tendon
- It can worsen weakness in people with a disease called myasthenia gravis.
- Peripheral neuropathy
- CNS problems, for example, nervousness, agitation, dizziness, paranoia, hallucinations, nightmares, and anxiety
Common side effects of include:
- Abdominal pain
Other possible serious side effects and adverse events include:
- Liver dysfunction or failure
- High blood sugar (hyperglycemia)
- Renal failure (kidney failure)
- Cardiac arrest
- C. difficile associated diarrhea.
- Respiratory failure
- Anaphylaxis (shock)
This medicine interacts with drugs, for example:
- Diabetes medications
- theophylline (Respbid, Slo-Bid, Theo-24, Theolair)
- warfarin (Coumadin, Jantoven).
- Iron salts (sulfates)
- Sevelamer (Renagel)
- sildenafil (Viagra)
Doctors don't know if Cipro is safe to take if you are pregnant or breastfeeding. The dosage of this drug depends upon the type of bacterial infection you have. The brand name Proquin XR has been discontinued and is no longer available in the US.
Corneal DiseaseThe cornea is the clear outer layer of the eye. If it is damaged by disease, infection, or injury, vision problems may occur. Corneal problems can be detected by having an eye exam. Corneal problems can be prevented by protecting the eyes from injury and avoiding contact with people who have eye infections.
Corneal UlcerA corneal ulcer is an open sore on the cornea. Infection is a common cause of corneal ulcer. Symptoms and signs of corneal ulcer include redness, eye pain and discharge, blurred vision, photophobia, and a gray or white spot on the cornea. Treatment depends upon the cause of the corneal ulcer.
Crohns Disease vs Ulcerative Colitis UC
Crohn's disease and ulcerative colitis are diseases that cause inflammation of part of or the entire digestive tract (GI). Crohn's affects the entire GI tract (from the mouth to the anus), while ulcerative colitis or UC only affects the large and small intestine and ilium. Researchers do not know the exact cause of either disease. About 20% of people with Crohn's disease also have a family member with the disease. Researchers believe that certain factors may play a role in causing UC. Both Crohn's disease and ulcerative colitis are a type of inflammatory bowel disease, or IBD.
Crohn's disease and ulcerative colitis both have similar symptoms and signs, for example:
- Loss of appetite
- Weight loss
- Episodic and/or persistent diarrhea
- Abdominal pain and cramping
- Rectal bleeding
- Bloody stools
- Joint pain and soreness
- Eye redness or pain
Symptoms unique to Crohn's disease include:
- Skin changes
Symptoms of unique to ulcerative colitis include:
- Certain rashes
- An urgency to defecate (have a bowel movement)
Doctors diagnose both diseases with similar tests and procedures. While there is no cure for either disease, doctors and other health care professionals can help you treat disease flares, and manage your Crohn's or UC with medication, diet, nutritional supplements, and/or surgery.
CDC. "What is inflammatory bowel disease IBD?" Updated June 21, 2017.
NIH. National Institute of Diabetes and Digestive and Kidney Diseases. "Ulcerative Colitis." September 2014.
NIH. National Institute of Diabetes and Digestive and Kidney Diseases. "Symptoms and Causes of Crohn's Disease." November 2016.
NIH. National Human Genome Research Institute. "Learning About Crohn's Disease." Updated: Sep 27, 2011.
PubMed Health. "Ulcerative Colitis." Accessed Jul 24, 2017.
Is Diverticulitis ContagiousDiverticulitis is an inflammation of the diverticula or diverticulum. Diverticulitis causes are either infectious or noninfectious, however, it is not contagoius. Symptoms of diverticulitis include:
- changes in bowel habits,
- abdominal tenderness,
- swollen abdomen,
- fistula formation, and
- lower left abdominal pain.
Levaquin (levofloxacin) is an antibiotic for treating bacterial infections of the sinuses, skin, lungs, ears, bones, airways, and joints. Levaquin is often used to treat:
- Urinary tract infections
- Diarrhea caused by E. coli
- Campylobacter jejuni
- Acute bacterial sinusitis
- Acute bacterial exacerbation of chronic bronchitis
- Anthrax inhalation
- Complicated skin and skin structure infections like cellulitis, impetigo, and wound infections due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes.
Common side effects are rash, intestinal gas, vaginal itching or discharge, headache, nausea, vomiting, and diarrhea. Iron, calcium, zinc, nonsteroidal anti-inflammatory drugs (NSAIDs), and warfarin (Coumadin, Jantoven) interact with Levaquin. It also has been associated with tendonitis and tendon rupture; abnormal heart beats, and liver dysfunction. Levaquin is available as an oral solution of 25 mg/mL, clear greenish-yellow color. Talk with your doctor, pharmacist, or other health care professional if you have any questions about this drug.