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- Cipro vs. Flagyl Differences
- What is Cirpo? What is Flagyl? How do they work?
- What are the uses for Cipro vs. Flagyl?
- What are the side effects of Cirpo vs. Flagyl?
- What is the dosage of Cipro vs. Flagyl?
- What drug interactions occur with Cipro vs. Flagyl?
- Are Cipro and Flagyl safe to take if I'm pregnant or breastfeeding?
Cipro vs. Flagyl Differences
- Flagyl (metronidazole) and Cipro (ciprofloxacin) are both types of antibiotics used to treat bacterial infections.
- Flagyl also is used to treat some parasitic infections.
- The drugs are in different antibiotic drug classes. Flagyl is in the nitroimidazole antibiotic drug class, and Cipro is in the fluoroquinolone class of antibiotics.
- Common side effects of both Flagyl and Cipro include:
- Side effects of Flagyl that are different from Cipro include:
- Side effects of Cipro that are different from Flagyl include:
- Serious side effects of both Flagyl and Cipro include:
What is Cirpo? What is Flagyl? How do they work?
Ciprofloxacin is a fluoroquinolone antibiotic used to treat many types of bacterial infections. It is used to treat acute sinusitis, bone and joint infections, chronic bacterial prostatitis, infectious diarrhea, as empirical therapy in febrile neutropenic patients, intra-abdominal infections, lower respiratory tract infections, lung infections, chronic bronchitis, nosocomial pneumonia, skin/skin structure infections, urinary tract infections, urethral and cervical gonococcal infections, anthrax infection, intra-abdominal infections, typhoid fever, cervical and urethral gonorrhea, acute uncomplicated cystitis, and pneumonic and septicemic plague.
Flagyl is an antibiotic effective against anaerobic bacteria and certain parasites. It is used to treat anaerobic bacterial infections, sexually transmitted diseases, bacterial vaginosis, colorectal surgical infection, abscesses in the liver/pelvis/abdomen, C. difficile diarrhea, and acne rosacea. It also is used to treat parasitic infections including trichomoniasis, amebiasis, and Gardnerella infection. Flagyl also may be used in combination with other drugs to treat H. pylori infection that causes stomach or intestinal ulcers.
What are the uses for Cipro vs. Flagyl?
Doctors and other medical health-care professionals prescribe Cipro and Cipro XR to treat bacterial infections, for example:
- Skin infections
- Lung or airway Infections, for example, TB (tuberculosis), pneumonic and septicemic plague due to Yersinia pestis (Y. pestis), lower respiratory tract infections, and chronic bronchitis)
- Bone infections
- Joint infections
- Urinary tract infections (UTI) caused by certain bacteria such as E. coli.
- Infectious diarrheas caused by E. coli, Campylobacter jejuni, and Shigella bacteria.
- Anthrax patients with fever and low white blood cell counts, and intra-abdominal infections.
- Typhoid fever
- Cervical and urethral gonorrhea due to Neisseria gonorrhoeae
- Chronic bacterial prostatitis
- Acute uncomplicated cystitis
- Flagyl is used to treat parasitic infections including Giardia infections of the small intestine, amebic liver abscess, and amebic dysentery (infection of the colon causing bloody diarrhea), bacterial vaginosis, trichomonas vaginal infections, and carriers of trichomonas (both sexual partners) who do not have symptoms of infection.
- Flagyl is also used alone or in combination with other antibiotics in treating abscesses in the liver, pelvis, abdomen, and brain caused by susceptible anaerobic bacteria.
- Flagyl is also used in treating infection of the colon caused by a bacterium called C. difficile. Many commonly-used antibiotics can alter the type of bacteria that inhabit the colon. C. difficile is an anaerobic bacterium that can infect the colon when the normal types of bacteria in the colon are inhibited by common antibiotics. This leads to inflammation of the colon (pseudomembranous colitis) with severe diarrhea and abdominal pain.)
- Flagyl also is used in combination with other drugs to treat Helicobacter pylori (H. pylori) that causes stomach or intestinal ulcers.
- Flagyl topical gel is used for treating acne rosacea.
- Flagyl vaginal gel is used for treating bacterial vaginosis.
What are the side effects of Cirpo vs. Flagyl?
Cipro side effects
Warning: Serious adverse reactions of this Cipro
Cipro and Cipro XR as well as other antibiotics in the fluoroquinolone class of antibiotics has been associated with tendonitis and even tendon rupture, particularly the Achilles tendon. Some doctors and other medical professionals recommend that their patients discontinue vigorous exercise while they are taking fluoroquinolone antibiotics.
The most common side effects of Cipro, Cipro XR are:
- Abdominal pain
- Anaphylaxis, or shock, is a rare allergic reaction to this drug. This allergic reaction is a medical emergency and you are experiencing these symptoms seek medical immediately.
Symptoms of shock include:
Cipro serious side effects and adverse events
Possible serious side effects of Cipro, Cipro XR include:
- Peripheral neuropathy
- Central nervous system effects (CNS), for example, toxic psychosis, nervousness, agitation, insomnia, anxiety, nightmares, paranoia, dizziness, tremors, depression, and hallucinations.
- Clostridiumdifficile-associated diarrhea (CDAD)
- Abnormal heart beats
- Liver dysfunction
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- Allergic pneumonitis
- Interstitial nephritis
- Acute kidney failure
- Liver failure
Other serious side effects and adverse events of Cipro, Cipro XR include:
- Cipro, Cipro XR should be used with caution in patients with central nervous system diseases such as seizures, because rare seizures have been reported in patients receiving Cipro, Cipro XR.
- Cipro, Cipro XR should be avoided in children and adolescents less than 18 years of age, as safe use in these patients has not been established.
- Many antibiotics, including Cipro, Cipro XR, can alter the normal bacteria in the colon and encourage overgrowth of a bacterium responsible for the development of inflammation of the colon, (C. difficile or pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting Cipro, Cipro XR (diarrhea, fever, abdominal pain, and possibly shock) should contact their doctor immediately.
- Cardiac arrest
- Respiratory failure
Flagyl side effects
Flagyl is a useful antibiotic and is generally well tolerated with appropriate use.
The most common and minor side effects include:
- Loss of appetite
- A metallic taste
- Rarely a rash
- Abdominal cramps
- Dry mouth
- Dark-colored urine
- Metallic taste in mouth
- Weight loss (anorexia)
- Furry tongue
- Nasal congestion
- Vaginal dryness
Side effects that are uncomfortable, but may become serious include:
- Brain disease
- Mouth sores
- Pain with urination
- Prickling or tingling sensations that may become permanent
- Pelvic pain or pressure
- Decrease of libido
Serious side effects of Flagyl
Serious side effects of Flagyl are rare and the drug should be stopped if these symptoms appear:
What is the dosage of Cipro vs. Flagyl?
- For most infections the recommended oral dose for adults is 250-750 mg (immediate release tablets) every 12 hours or 500-1000 mg (extended release tablets) every 24 hours.
- The usual intravenous dose is 200-400 mg every 8-12 hours.
- Metronidazole may be taken orally with or without food.
- In the hospital, metronidazole can be administered intravenously to treat serious infections.
- The liver is primarily responsible for eliminating metronidazole from the body, and doses may need to be reduced in patients with liver disease and abnormal liver function.
Various metronidazole regimens are used. Some examples are listed below.
- Amebic dysentery: 750 mg orally 3 times daily for 5-10 days
- Amebic liver abscess: 500-750 mg orally three times daily for 5-10 days
- Anaerobic infections: 7.5 mg/kg orally or by injection every 6 hours for 7 to 10 days not to exceed 4 grams daily.
- Bacterial vaginosis: 750 mg (extended release tablets) once daily for 7 days or 500 mg twice daily for 7 days or 2 g single dose or one applicator-full of 0.75% vaginal gel, once or twice daily for 5 days.
- Clostridium difficile infection: 250-500 mg orally 4 times daily or 500-750 orally 3 times daily
- Giardia: 250 mg orally three times daily for 5 days Helicobacter pylori: 800-1500 mg orally daily for several days in combination with other drugs.
- Pelvic inflammatory disease (PID): 500 mg orally twice daily for 14 days in combination with other drugs.
- Trichomoniasis: 2 g single dose or 1 g twice
- Rosacea: apply topical gel 0.75-1% once daily
What drug interactions occur with Cipro vs. Flagyl?
Cipro drug interactions
- Ciprofloxacin administered together with theophylline (Respbid, Slo-Bid, Theo-24, Theolair) can lead to elevated, toxic blood levels of theophylline. Theophylline is used to open airways in the treatment of asthma. Toxic levels of theophylline can lead to seizures, and disturbances in heart rhythm. If concurrent use of ciprofloxacin and theophylline cannot be avoided, frequent blood tests to monitor theophylline blood levels are recommended.
- Ciprofloxacin increases the effect of tizanidine (Zanaflex) that is used to treat muscle spasticity. Therefore, the two drugs should not be combined.
- Iron salts (for example, ferrous sulfate) may reduce the absorption of ciprofloxacin because of formation of a ciprofloxacin-iron complex that is not absorbable. Antacids also may reduce the absorption of ciprofloxacin. If patients are receiving iron salts or antacids and ciprofloxacin, the ciprofloxacin should be given two hours before or six hours after the iron salt or antacid.
- Ciprofloxacin may increase the blood thinning effect of warfarin (Coumadin, Jantoven). The reason for this is unknown. Anticoagulant activity should be monitored after starting or stopping ciprofloxacin.
- Sevelamer (Renagel) may reduce the absorption of ciprofloxacin and possibly reduce the effectiveness of ciprofloxacin. Milk and orange juice also may reduce the absorption of ciprofloxacin. Ciprofloxacin, as with iron and antacids, should be given two hours before or six hours after milk or orange juice.
- Administration of ciprofloxacin with diabetic medications (for example glyburide [Micronase, Diabeta, Glynase, Prestab]) may lead to severe low blood glucose.
- Ciprofloxacin may increase blood concentrations of sildenafil (Viagra) that is used for treating erectile dysfunction. This combination should be avoided if possible.
- Patients taking Cipro, Cipro XR can develop sensitivity of the skin to direct sunlight (photosensitivity) and should avoid exposure to sunlight or use sunblock.
- Fluoroquinolones worsen low blood glucose levels when combined with sulfonylureas, for example, glyburide (Micronase, Diabeta, Glynase, Prestab).
Flagyl drug interactions
- Alcohol should be avoided because metronidazole and alcohol together can cause severe nausea, vomiting, cramps, flushing, and headache.
- Metronidazole can increase the blood thinning effects of warfarin (Coumadin, Jantoven) and increase the risk of bleeding probably by reducing the breakdown of warfarin.
- Cimetidine (Tagamet) increases blood levels of metronidazole while cholestyramine (Questran, Questran Light) reduces blood levels of metronidazole by reducing its absorption.
- Metronidazole should not be combined with amprenavir (Agenerase) for treating human immunodeficiency disease (infection with HIV) because amprenavir contains propylene glycol.
- Metronidazole blocks the breakdown of propylene glycol in the liver leading to accumulation of propylene glycol in blood. Accumulation of propylene glycol could cause seizures, increased heart rate, and lead to kidney failure.
- Metronidazole increases the blood levels of carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), lithium (Eskalith, Lithobid) and cyclosporine though unknown mechanisms. Serious reactions may occur if these drugs are taken with metronidazole.
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Are Cipro and Flagyl safe to take if I'm pregnant or breastfeeding?
- Doctors suggest that should not use Cipro if you are pregnant or breastfeeding because they do not know if it is safe.
- Flagyl is not used in early pregnancy because of potential adverse effects on the fetus. Metronidazole is excreted in breast milk. Females who are nursing, because of potential adverse effects on the newborn, should not use metronidazole.
Cipro, generic name ciprofloxacin, is an antibiotic that belongs to a class of antibiotics called fluoroquinolones, prescribed for the treatment a variety of bacterial infections. Flagyl, generic name metronidazole, is an antibiotic prescribed for the treatment of parasites and anaerobic bacteria. Review side effects, dosage, drug interactions, and pregnancy and breastfeeding safety information prior to using these antibiotics.
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H. pylori (Helicobacter Pylori) Infection
Helicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach, and also is the most common cause of ulcers worldwide. About 50% of people in the world carries or is infected with H. pylori. Common symptoms of H. pylori infection are occasional abdominal discomfort, bloating, belching or burping, and nausea and vomiting. H. pylori infection is difficult to eradicate, and treatment is with two or more antibiotics.
Gonorrhea In Women
Gonorrhea is a bacterial infection transmitted during sexual contact. In women, symptoms include a yellow vaginal discharge, burning or frequent urination, and redness, swelling, burning, and itching of the vaginal area. Gonorrhea can be treated with injectable (penicillin) or oral medications.
Bacterial Vaginosis (BV)
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Sexually Transmitted Diseases (STDs)
Common sexually transmitted diseases (STDs) in women include gonorrhea, chlamydia, genital herpes, and HPV infection (genital warts). Learn about types, symptoms, and treatment.
Prostatitis (Inflammation of the Prostate Gland)
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Giardiasis (Giardia lamblia) is a parasite responsible for a common form of infectious diarrhea. The parasite lives in two stages: trophozoites and cysts. People at risk for giardiasis are those that live in areas where there is inadequate sanitation or treatment of drinking water. Giardiasis also is a common cause of outbreaks of diarrhea in day-care centers. Symptoms and signs of giardiasis include abdominal pain, stomach cramping, bloating, nausea, and fatigue. Treatment for giardiasis is with antibiotic medication.
Mycobacterium tuberculosis is the bacterium that causes tuberculosis (TB). Symptoms and signs of TB include bloody sputum, fever, cough, weight loss, and chest pain. Treatment depends upon the type of TB infection.
Is a Urinary Tract Infection (UTI) Contagious?
Bacteria such as E. coli or Pseudomonas can cause a urinary tract infection (UTI). The incubation period for a UTI ranges from three to eight days.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Is Tuberculosis (TB) Contagious?
Mycobacterium tuberculosis causes tuberculosis (TB). TB may be transmitted when an infected person sings, sneezes, coughs, or talks. TB symptoms and signs include coughing bloody sputum, night sweats, severe cough, fever, chills, fatigue, and weight loss.
Prostatitis vs. BPH (Enlarged Prostate): What Is the Difference?
Prostatitis and BPH (benign prostatic hyperplasia, enlarged prostate gland) are both conditions of the prostate gland. There are four types of prostatitis that can be caused by infections (usually bacterial) or other health conditions or problems, acute bacterial prostatitis (type I), chronic bacterial prostatitis (type II), chronic prostatitis and chronic pelvic pain syndrome (type III), and asymptomatic inflammatory prostatitis (type IV). BPH is inflammation of the prostate gland, and most men have the condition by age 50. Doctor's don't know what causes this inflammation, but they theorize that it may be related to hormones. Both of these conditions can cause similar symptoms like low back pain, pain during urination, or difficulty or the inability to urinate. However, prostatitis has many more symptoms and signs than BPH, and they based on the type of prostatitis. Examples include low back pain and/or abdominal pain, painful urination, fever, chills, feeling tired, recurrent urinary tract infections (UTIs), painful urination intermittently, intermittent obstruction urinary tract symptoms (frequent, painful, or incomplete urination), pelvic pain and/or discomfort, pain with ejaculation, and erectile dysfunction (ED). If you think you have either of these conditions contact your doctor or other health care professional. Bacterial prostatitis can be cured with antibiotics; however, there is no cure for BPH.
Plague (Black Death)
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Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
Is H. pylori Contagious?
H. pylori (Helicobacter pylori) infection: Is it contagious? H. pylori infection is caused by fecal contamination in either food or water, and by poor hygiene practices such as not washing the hands often. Common symptoms of H. pylori are a discomfort or pain in the area of the stomach. Some individuals describe the pain as gnawing or burning. Treatment of H. pylori infection is antibiotic therapy.
Is C. diff (Clostridium difficile) Contagious?
C. diff, or Clostridium difficile, is a bacteria that infects the colon. C. diff bacteria can be found on furniture, bathroom floors, telephones, fingernails, jewelry, toilet seats, and other places. Symptoms of C. diff infection are fever, abdominal pain, and cramps; however, not all people infected with C. diff have symptoms. Treatments for C. diff are antibiotics and surgery in some cases.
Anthrax is a deadly infectious disease that may be transmitted to humans by infected animals or by biological warfare. There are three types of anthrax: cutaneous, inhalation, and gastrointestinal. Symptoms of cutaneous anthrax include a swollen glands, muscle ache, headache, fever, nausea, vomiting, and a red-brown raised spot that enlarges, blisters, and hardens, forming an ulcer crater with black crust. Symptoms of inhalation anthrax are flu-like and may progress to respiratory distress, shock, coma, and death. Symptoms of gastrointestinal anthrax include loss of appetite, bloody diarrhea, and abdominal pain. Treatment for cutaneous anthrax involves penicillin, tetracycline, erythromycin, and ciprofloxin. Inhalation anthrax necessitates treatment with IV therapy with antibiotics.
Is E. coli Contagious? (Symptoms and Cure)
E. coli is an infection found worldwide. There are several subtypes of the E. coli species. E. coli spreads from person to person via contaminated food or water. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Antibiotics treat E. coli infection.
Typhoid fever is an illness caused by the Salmonella typhi bacteria. The illness is contracted by ingesting the bacteria in contaminated water or food. Symptoms include headaches, fever, diarrhea, lethargy, aches and pains, and poor appetite. Treatment focuses on killing the Salmonella bacteria with antibiotics.
Clostridium Difficile Colitis (C. diff, C. difficle Colitis)
Clostridium difficile (C. difficile) is a bacterium, and is one of the most common causes of infection of the colon. C. difficile spores are found frequently in hospitals, nursing homes, extended care facilities, and nurseries for newborn infants.
Urinary Tract Infections in Children
Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting, and blood in the urine. Treatment for a UTI involves antibiotic therapy.
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Nontuberculous mycobacteria (NTM), most commonly, M. avium complex or MAC, is a mycobacteria that causes lung infections and disease. Nontuberculous mycobacteria are commonly found in soil, air, and water. Examples of how NTM lung infection are transmitted include swimming, using a hot tub (NTM bacteria are aerosolized), or playing with or handling soil. The most common symptoms of NTM lung infection are chronic, dry cough, and shortness of breath. Sometimes the cough may have mucous or blood. Other symptoms of NTM lung disease include fatigue, chest pain, malaise, and weakness. As NTM lung disease progresses, fevers, night sweats, and appetite loss may occur. Treatment guidelines for NTM lung disease depend upon the type and extent of the infection, and the person's health.
Enterovirulent E. coli (EEC)
Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Symptoms may vary depending on the strain the individual contracts. Infection is spread generally through contaminated food or drink.
Extensively Drug-Resistant Tuberculosis (XDR TB)
Extensively drug-resistant tuberculosis (XDR TB) is a rare form of multidrug-resistant tuberculosis (MDR TB) that's transmitted when TB germs are expelled into the air by sneezing, speaking, singing, or coughing.
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
Emphysema, Chronic Bronchitis, and Colds
If you have a COPD such as emphysema, avoiding chronic bronchitis and colds is important to avoid a more severe respiratory infection such as pneumonia. Avoiding cigarette smoking, practice good hygeine, stay away from crowds, and alerting your healthcare provider if you have a sinus infection or cold or cough that becomes worse. Treatment options depend upon the severity of the emphysema, bronchitis, or cold combination.
Treatment & Diagnosis
Medications & Supplements
- metronidazole (Flagyl, Flagyl ER) Antibiotic
- Flagyl (metronidazole) Side Effects, Warnings, and Interactions
- Levaquin (levofloxacin) Antibiotic
- Metronidazole (Flagyl) vs. Fluconazole (Diflucan)
- Cipro, Cipro XR (ciprofloxacin) Antibiotic Side Effects
- Cipro, XR (ciprofloxacin) vs. Keflex (cephalexin)
- Cipro vs. Levaquin
- Nitrofurantoin vs. Ciprofloxacin
- norfloxacin (Noroxin)
- ofloxacin (Floxin Discontinued Brand)
- levofloxacin (Levaquin) Side Effects and Adverse Effects
- moxifloxacin (Avelox)
- moxifloxacin - injection, Avelox
- gatifloxacin-oral, Tequin
- trovafloxacin mesylate, Trovan
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