- What brand names are available for chlorthalidone?
- Is chlorthalidone available as a generic drug?
- Do I need a prescription for chlorthalidone?
- What are the uses for chlorthalidone?
- What are the side effects of chlorthalidone?
- What is the dosage for chlorthalidone?
- Which drugs or supplements interact with chlorthalidone?
- Is chlorthalidone safe to take if I'm pregnant or breastfeeding?
- What else should I know about chlorthalidone?
What brand names are available for chlorthalidone?
Hygroton, Thalitone (both discontinued in U.S.A.)
What are the uses for chlorthalidone?
What are the side effects of chlorthalidone?
Chlorthalidone generally is well tolerated.
Side effects include:
More serious side effects include:
- Low blood levels of potassium, sodium, and magnesium due to increased excretion via urine.
- High blood calcium levels also can occur, especially in persons who are taking calcium supplements.
- Thiazide diuretics such as chlorthalidone increase the levels of uric acid in the blood, but gout (which is caused by high levels of uric acid) rarely occurs.
- Chlorthalidone can cause high blood sugars in patients with diabetes.
What is the dosage for chlorthalidone?
The optimal dose of chlorthalidone varies greatly from patient to patient.
For high blood pressure the recommended dose range is 25 to 100 mg daily. Most patients receive 12.5 to 25 mg daily.
Edema is treated with 50 to 100 mg daily or 100 mg every other day and the maximum dose is 200 mg daily.
Heart failure is treated with 12.5 to 100 mg daily.
Which drugs or supplements interact with chlorthalidone?
Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine. This is especially true in patients who are also taking another class of diuretics, called loop diuretics which includes furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex). Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin (Lanoxin).
Chlorthalidone reduces the kidney's ability to eliminate lithium (Eskalith, Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and lithium toxicity.
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of chlorthalidone though the reason for this is not clear. Blood sugar levels can be elevated by thiazide diuretics. Patients with diabetes may need to adjust the doses of of medications they are taking for treating diabetes.
Is chlorthalidone safe to take if I'm pregnant or breastfeeding?
Thiazide diuretics including chlorthalidone cross the placenta and can cause jaundice in the fetus or newborn. Therefore, chlorthalidone should not be used during pregnancy unless absolutely necessary.
Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
What Is High Blood Pressure (Hypertension)? Symptoms, Treatments
What causes high blood pressure (hypertension)? What is normal blood pressure? Know the warning signs and symptoms of high blood...
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Related Disease Conditions
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Edema is swelling caused by fluid accumulation in the tissues of the body and occurs most often in the legs, feet, ankles, or hands. Learn about different types, symptoms, causes, and treatment.
Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Treatment & Diagnosis
- High Blood Pressure FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information