- Side Effects
- Drug Interactions
- What Else to Know
Generic Name: chlorpheniramine/pseudoephedrine
Brand Name: Deconamine (discontinued)
What is chlorpheniramine/pseudoephedrine, and what is it used for?
Deconamine was a brand name medication that contains two different drugs, an antihistamine (chlorpheniramine) and a decongestant (pseudoephedrine). The antihistamine effects of chlorpheniramine account for its effect of reducing allergy symptoms. The decongestant action of pseudoephedrine is a result of blood vessel constriction in the nasal air passages, such as in the nose or sinuses.
Brand name and generic formulations of combination products containing only chlorpheniramine and pseudoephedrine have been discontinued in the U. S., most likely due to the regulation of pseudoephedrine distribution.
Chlorpheniramine and pseudoephedrine (discontinued brand name Deconamine) was prescribed for the treatment of temporary relief of runny nose, sneezing, nasal congestion from the common cold, sinusitis, and hay fever.
What are the side effects of chlorpheniramine/pseudoephedrine?
Side effects of antihistamines include:
- impaired ability to accurately operate machinery,
- worsening of glaucoma,
- worsening of asthma or chronic lung diseases,
- dry mouth or throat,
- low blood counts,
- ringing in the ears,
- stomach upset, and
- urinary frequency or difficulty.
Other important side effects of pseudoephedrine include stimulation of the nervous system leading to:
What is the dosage for chlorpheniramine/pseudoephedrine?
The combination drug may be taken with or without food. It must be used cautiously in patients with heart (coronary artery) disease and angina, diabetes, lung diseases, especially asthma, glaucoma, and narrowing of the stomach exit (pyloric stenosis).
Which drugs interact with chlorpheniramine/pseudoephedrine?
- The combination drug can cause drowsiness and impaired ability to operate machinery. It contains pseudoephedrine which should not be taken with MAO inhibitors drugs.
- Caution must be exercised in the administration of this drug to patients with heart or lung disease.
- The combination drug should not be combined with other drugs containing pseudoephedrine (such as Sudafed) because of increased risk of side effects on the heart and blood vessels.
- While misuse of the combination drug for the purpose of getting "high" is unfamiliar to the editors, it is a specific warning from the manufacturer that patients be aware of possible "additive" effects of the drug when taken with alcohol and other central nervous depressants (such as sedatives and tranquilizers). This means that when the drug is taken with, for example, alcohol, the effect of the alcohol could be magnified. Conversely, alcohol increases the sedating qualities of Deconamine.
What else should I know about chlorpheniramine/pseudoephedrine?
What preparations of chlorpheniramine, pseudoephedrine are available?
Tablets of 4 mg chlorpheniramine/60 mg pseudoephedrine; chew tabs of 1 mg c/15 mg p; syrup of 2 mg c/30 mg p.
How should I keep chlorpheniramine, pseudoephedrine stored?
Combinations of chlorpheniramine and pseudoephedrine should be stored at room temperature in an air-tight container.
The combination of chlorpheniramine and pseudoephedrine (discontinued brand name Deconamine) was a medication prescribed for the treatment and temporary relief of runny nose, sneezing, and nasal congestion from the common cold, sinusitis, and hay fever.
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Related Disease Conditions
Sinus Infection (Sinusitis)
Sinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
Chronic Rhinitis and Post-Nasal Drip
Chronic rhinitis (non allergic rhinitis) causes runny nose, sneezing, nasal itching and congestion. Post-nasal drip is drainage of mucus from the sinuses into the throat. Treatment includes over-the-counter (OTC) medications.
Itch (Itching or Pruritus)
Itching can be a common problem. Itches can be localized or generalized. There are many causes of itching including infection (jock itch, vaginal itch), disease (hyperthyroidism, liver or kidney), reactions to drugs, and skin infestations (pubic or body lice). Treatment for itching varies depending on the cause of the itch.
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Cold and Cough Medicine for Infants and Children
The safety of giving infants and children over-the-counter (OTC) cold and cough medicine is important for caregivers to understand. While there is no "gold standard" recommendation for giving infants and children OTC cold and cough medicine for fever, aches, cough, and runny nose, a few standards have been recommended.
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Viruses cause the common cold and the flu. Early symptoms and signs for a cold and the flu are similar, however, flu symptoms are typically more severe than cold symptoms. Cold and flu viruses are transmitted typically via coughing or sneezing.
Common Cold: Early Signs and 4 Stages
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Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
Indoor allergens are substances that can cause an allergic reaction in some people. Common sources of indoor allergens include dust mites, cockroaches, molds, pets, and plants. Avoiding indoor allergens is one way to reduce allergy and asthma symptoms.
Cold, Flu, Allergy Treatments
Before treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
COVID-19 vs. Flu vs. Cold
When you're feeling sick, it can be difficult to distinguish the symptoms of a COVID-19 infection from the symptoms of the common cold or the flu (influenza). While fever is common with the flu and COVID-19, sneezing is typically only associated with colds. Though sore throats are typical with colds, they are uncommon with COVID-19 infections and the flu.
Allergy Treatment Begins at Home
Avoiding allergy triggers at home is one of the best ways to prevent allergy symptoms. Controlling temperature, humidity, and ventilation are a few ways to allergy-proof the home. Cleaning, vacuuming, and using HEPA air filters also helps control allergies.
Cold vs. Flu
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Teen Drug Abuse
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Is It a Cold or a Sinus Infection?
A sinus infection, also known as sinusitis or rhinosinusitis, is a condition in which the delicate membranes that line the sinuses may get swollen and become red. A cold or common cold is a viral infection. It affects the upper respiratory system, which includes the nose, mouth, throat, and lungs.
Why Won’t My Allergy Symptoms Go Away?
Allergies happen when your body's immune system reacts to certain substances as though they are harmful. Allergy symptoms may not go away unless you avoid your triggers, stick to your medications, find the right combination of medications, and consider surgery.
COVID-19 vs. Allergies
Though there is some overlap in allergy and COVID-19 signs and symptoms there are also significant differences. Symptoms that they have in common include headache, fatigue, tiredness, shortness of breath, wheezing, and sore throat. Fever does not occur with allergies but is one of the defining symptoms of COVID-19 infections.
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If your baby has a cold, signs that it may be time to see a doctor include poor feeding, dehydration, breathing difficulties, ear pain, and more.
How Do You Tell If Your Child Has Allergies or a Cold?
Colds and allergies have different causes, but both involve the body's immune system. Since the symptoms of allergies and the symptoms of a cold overlap, it can be hard to tell which one your child has.
How Long Does a Cold Last?
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Treatment & Diagnosis
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Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.