What is chlordiazepoxide hydrochloride and clidinium bromide, and how does it work (mechanism of action)?

Chlordiazepoxide hydrochloride and clidinium bromide (Librax) combines the anti-anxiety action of chlordiazepoxide and the antispasmodic effects of clidinium. It also blocks the acid secretion of the gastrointestinal tract and inhibits the action of nerves that are very active in certain diseases. The FDA classifies the combination as possibly effective as additional therapy for treatment of peptic ulcers, irritable bowel syndrome (IBS), GI spasms and some intestinal infections.

What brand names are available for chlordiazepoxide hydrochloride and clidinium bromide?

Librax

Is chlordiazepoxide hydrochloride and clidinium bromide available as a generic drug?

GENERIC AVAILABLE: yes

Do I need a prescription for chlordiazepoxide hydrochloride and clidinium bromide?

yes

What are the uses for chlordiazepoxide hydrochloride and clidinium bromide?

Chlordiazepoxide hydrochloride and clidinium bromide is a prescription drug used as therapy for peptic ulcer disease and IBS (irritable bowel syndrome). It also may be useful in management of acute gastroenteritis (stomach flu).

What are the side effects of chlordiazepoxide hydrochloride and clidinium bromide?

  • Adverse reactions may include drowsiness, dizziness, and confusion. Nausea, constipation, and dry mouth may occur.
  • Urinary hesitancy or retention are seen, particularly in the elderly.
  • Skin eruptions and liver abnormalities are less common.
  • Avoid driving or operating machinery while taking chlordiazepoxide hydrochloride/clidinium bromide because it reduces mental alertness.

What is the dosage for chlordiazepoxide hydrochloride and clidinium bromide?

Chlordiazepoxide hydrochloride/clidinium bromide may be taken with or without food. Take 1 to two capsules every 6 to 8 hours before meals and at bedtime.

QUESTION

Pancreatitis is inflammation of an organ in the abdomen called the pancreas. See Answer

Which drugs or supplements interact with chlordiazepoxide hydrochloride and clidinium bromide?

Chlordiazepoxide hydrochloride/clidinium bromide should not be used in people with glaucoma or urinary retention (difficulty urinating) due to benign prostatic hypertrophy (BPH) because clidinium blocks the action of choline, increasing intraocular pressure and causing difficulty urinating. Chlordiazepoxide has sedative effects and should not be combined with alcohol or other central nervous system depressants.

Is chlordiazepoxide hydrochloride and clidinium bromide safe to take if I'm pregnant or breastfeeding?

Chlordiazepoxide hydrochloride/clidinium bromide is not recommended for use in pregnant women because it increases the risk of congenital malformations during the first trimester.

What else should I know about chlordiazepoxide hydrochloride and clidinium bromide?

What preparations of chlordiazepoxide hydrochloride and clidinium bromide are available?

Capsules: 5mg chlordiazepoxide hydrochloride and 2.5mg clidinium bromide.

How should I keep chlordiazepoxide hydrochloride and clidinium bromide stored?

Capsules should be stored at room temperature in a tightly close container.

Summary

Chlordiazepoxide hydrochloride and clidinium bromide (Librax) is a prescription drug used as therapy for peptic ulcer disease and IBS (irritable bowel syndrome). Librax also may be useful in management of acute gastroenteritis (stomach flu). Review side effects, drug interactions, dosage, storage, and pregnancy safety information prior to taking this drug.

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Medically Reviewed on 8/9/2019
References
FDA Prescribing Information
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