chlordiazepoxide hydrochloride and clidinium bromide

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What is chlordiazepoxide hydrochloride, clidinium bromide, and how does it work (mechanism of action)?

Chlordiazepoxide hydrochloride and clidinium bromide (Librax) combines the anti-anxiety action of chlordiazepoxide and the antispasmodic effects of clidinium. It also blocks the acid secretion of the gastrointestinal tract and inhibits the action of nerves that are very active in certain diseases. The FDA classifies the combination as possibly effective as additional therapy for treatment of peptic ulcers, irritable bowel syndrome (IBS), GI spasms and some intestinal infections.

What brand names are available for chlordiazepoxide hydrochloride, clidinium bromide?


Is chlordiazepoxide hydrochloride, clidinium bromide available as a generic drug?


Do I need a prescription for chlordiazepoxide hydrochloride, clidinium bromide?


What are the side effects of chlordiazepoxide hydrochloride, clidinium bromide?

  • Adverse reactions may include drowsiness, dizziness, and confusion. Nausea, constipation, and dry mouth may occur.
  • Urinary hesitancy or retention are seen, particularly in the elderly.
  • Skin eruptions and liver abnormalities are less common.
  • Avoid driving or operating machinery while taking chlordiazepoxide hydrochloride/clidinium bromide because it reduces mental alertness.

What is the dosage for chlordiazepoxide hydrochloride, clidinium bromide?

Chlordiazepoxide hydrochloride/clidinium bromide may be taken with or without food. Take 1 to two capsules every 6 to 8 hours before meals and at bedtime.

Which drugs or supplements interact with chlordiazepoxide hydrochloride, clidinium bromide?

Chlordiazepoxide hydrochloride/ clidinium bromide should not be used in people with glaucoma or urinary retention (difficulty urinating) due to benign prostatic hypertrophy (BPH) because clidinium blocks the action of choline, increasing intraocular pressure and causing difficulty urinating. Chlordiazepoxide has sedative effects and should not be combined with alcohol or other central nervous system depressants.

Is chlordiazepoxide hydrochloride, clidinium bromide safe to take if I'm pregnant or breastfeeding?

Chlordiazepoxide hydrochloride/clidinium bromide is not recommended for use in pregnant women because it increases the risk of congenital malformations during the first trimester.

What else should I know about chlordiazepoxide hydrochloride, clidinium bromide?

What preparations of chlordiazepoxide hydrochloride, clidinium bromide are available?

Capsules: 5mg chlordiazepoxide hydrochloride and 2.5mg clidinium bromide.

How should I keep chlordiazepoxide hydrochloride, clidinium bromide stored?

Capsules should be stored at room temperature in a tightly close container.

Quick GuideDigestive Disorders: Common Misconceptions

Digestive Disorders: Common Misconceptions


Chlordiazepoxide hydrochloride and clidinium bromide (Librax) is a prescription drug used as therapy for peptic ulcer disease and IBS (irritable bowel syndrome). Librax also may be useful in management of acute gastroenteritis (stomach flu). Side effects, drug interactions, dosage, storage, and pregnancy safety should be reviewed prior to taking this drug.

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Reference: FDA Prescribing Information