Charcot-Marie-Tooth Disease: Symptoms & Signs

Charcot-Marie-Tooth disease (CMT) is a common inherited neurological condition. It is made up of several types of conditions affecting both motor and sensory peripheral nerves and may worsen with time.

Signs and symptoms of Charcot-Marie-Tooth disease include difficulty with walking, problems with swallowing, loss of muscle bulk, muscle weakness, leg pain, foot drop, and foot deformities such as hammertoe. Other associated symptoms and signs can include sensory loss (such as a reduced sensation of touch), weakness in the hand muscles or hand contractures, high foot arches, and gait abnormalities.

Causes of Charcot-Marie-Tooth disease

Inherited gene mutations cause Charcot-Marie-Tooth disease. These genetic defects result in abnormal proteins involved in the structure of peripheral nervous system-nerve axons or the myelin sheaths that protect the nerves.

Other charcot-marie-tooth disease symptoms and signs

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Medically Reviewed on 9/10/2019
References
Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.
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