Charcot-Marie-Tooth Disease: Symptoms & Signs

Medically Reviewed on 9/10/2019

Charcot-Marie-Tooth disease (CMT) is a common inherited neurological condition. It is made up of several types of conditions affecting both motor and sensory peripheral nerves and may worsen with time.

Signs and symptoms of Charcot-Marie-Tooth disease include difficulty with walking, problems with swallowing, loss of muscle bulk, muscle weakness, leg pain, foot drop, and foot deformities such as hammertoe. Other associated symptoms and signs can include sensory loss (such as a reduced sensation of touch), weakness in the hand muscles or hand contractures, high foot arches, and gait abnormalities.

Causes of Charcot-Marie-Tooth disease

Inherited gene mutations cause Charcot-Marie-Tooth disease. These genetic defects result in abnormal proteins involved in the structure of peripheral nervous system-nerve axons or the myelin sheaths that protect the nerves.

Other charcot-marie-tooth disease symptoms and signs


Brain Food Pictures: What to Eat to Boost Focus See Slideshow

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Kasper, D.L., et al., eds. Harrison's Principles of Internal Medicine, 19th Ed. United States: McGraw-Hill Education, 2015.