- What is cerivastatin, and how does it work (mechanism of action)?
- What brand names are available for cerivastatin?
- Is cerivastatin available as a generic drug?
- Do I need a prescription for cerivastatin?
- What are the side effects of cerivastatin?
- What is the dosage for cerivastatin?
- Which drugs or supplements interact with cerivastatin?
- Is cerivastatin safe to take if I'm pregnant or breastfeeding?
- What else should I know about cerivastatin?
What is cerivastatin, and how does it work (mechanism of action)?
Cerivastatin is a drug that lowers cholesterol in the blood by blocking the enzyme in the liver that is responsible for producing cholesterol. It lowers total cholesterol as well as the LDL subfraction of cholesterol in the blood. LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease. Lowering LDL cholesterol levels retards and may even reverse coronary artery disease. Cerivastatin is in the same class of drugs (HMGCoA reductase inhibitors) as atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), lovastatin (Mevacor), and fluvastatin (Lescol). Cerivastatin was approved by the FDA in 1997.
What are the side effects of cerivastatin?
Cerivastatin generally is well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, nasal congestion, and headache. Cerivastatin should be used with caution in patients with alcoholic or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle damage due to inflammation (myositis) have been reported with other drugs in the same class as cerivastatin, and is presumed also to occur with cerivastatin as well. (Muscle inflammation causes the release of muscle protein, myoglobin, into the blood where it is carried to the kidneys and leads to kidney failure.)
What is the dosage for cerivastatin?
Cerivastatin usually is taken once daily at bedtime. It may be taken with or without food.
Which drugs or supplements interact with cerivastatin?
With other drugs in the same class as cerivastatin, the risk of muscle damage (see below) is increased when they are given at the same time as other medications such as cyclosporine (Sandimmune; Neoral), gemfibrozil (Lopid), erythromycin, itraconazole (Sporanox) and nicotinic acid. It is assumed that cerivastatin will interact similarly.
Is cerivastatin safe to take if I'm pregnant or breastfeeding?
It is not known if cerivastatin causes harm to the fetus if taken during pregnancy. Cerivastatin may be used in pregnancy if the physician feels that its benefits outweigh its potential risks.
It is not known if cerivastatin is secreted in breast milk. Therefore, the physician and patient must weigh the benefits against the potential risks of treating nursing mothers.
What else should I know about cerivastatin?
What preparations of cerivastatin are available?
Tablets, 0.3mg, 0.4mg, and 0.8mg.
How should I keep cerivastatin stored?
Tablets should be stored at room temperature, 15-30°C (59-86°F).
Quick GuideLower Your Cholesterol, Save Your Heart
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Peripheral Vascular Disease (PVD Symptoms, Signs, Causes, Treatments)
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and...
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management....
Treatment & Diagnosis
- High Cholesterol (Hyperlipidemia) FAQs
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: The Most Common Medication Errors
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- What Are the Risks and Side Effects of Zocor?
- Does Nizoral Shampoo Interfere with Statins?
- Grapefruit Juice and Drug Interactions
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
- Surgery Second Opinion
- Caregivers: Don't Forget Your Needs
- Drug Abuse Recovery
- Dupuytren’s Treatment
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information