- What is cerivastatin, and how does it work (mechanism of action)?
- What brand names are available for cerivastatin?
- Is cerivastatin available as a generic drug?
- Do I need a prescription for cerivastatin?
- What are the side effects of cerivastatin?
- What is the dosage for cerivastatin?
- Which drugs or supplements interact with cerivastatin?
- Is cerivastatin safe to take if I'm pregnant or breastfeeding?
- What else should I know about cerivastatin?
What is cerivastatin, and how does it work (mechanism of action)?
Cerivastatin is a drug that lowers cholesterol in the blood by blocking the enzyme in the liver that is responsible for producing cholesterol. It lowers total cholesterol as well as the LDL subfraction of cholesterol in the blood. LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease. Lowering LDL cholesterol levels retards and may even reverse coronary artery disease. Cerivastatin is in the same class of drugs (HMGCoA reductase inhibitors) as atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), lovastatin (Mevacor), and fluvastatin (Lescol). Cerivastatin was approved by the FDA in 1997.
What are the side effects of cerivastatin?
Cerivastatin generally is well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, nasal congestion, and headache. Cerivastatin should be used with caution in patients with alcoholic or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle damage due to inflammation (myositis) have been reported with other drugs in the same class as cerivastatin, and is presumed also to occur with cerivastatin as well. (Muscle inflammation causes the release of muscle protein, myoglobin, into the blood where it is carried to the kidneys and leads to kidney failure.)
Quick GuideLower Your Cholesterol, Save Your Heart
What is the dosage for cerivastatin?
Cerivastatin usually is taken once daily at bedtime. It may be taken with or without food.
Which drugs or supplements interact with cerivastatin?
With other drugs in the same class as cerivastatin, the risk of muscle damage (see below) is increased when they are given at the same time as other medications such as cyclosporine (Sandimmune; Neoral), gemfibrozil (Lopid), erythromycin, itraconazole (Sporanox) and nicotinic acid. It is assumed that cerivastatin will interact similarly.
Is cerivastatin safe to take if I'm pregnant or breastfeeding?
It is not known if cerivastatin causes harm to the fetus if taken during pregnancy. Cerivastatin may be used in pregnancy if the physician feels that its benefits outweigh its potential risks.
It is not known if cerivastatin is secreted in breast milk. Therefore, the physician and patient must weigh the benefits against the potential risks of treating nursing mothers.
What else should I know about cerivastatin?
What preparations of cerivastatin are available?
Tablets, 0.3mg, 0.4mg, and 0.8mg.
How should I keep cerivastatin stored?
Tablets should be stored at room temperature, 15-30°C (59-86°F).
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information
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Lipitor (atorvastatin) is a drug in the statin drug classed prescribed to patients to lower blood cholesterol, LDL, and triglycerides, elevate HDL cholesterol, to prevent angina, stroke, heart attack, congestive heart failure, revascularization procedures in heart disease, and prevent heart attacks, and strokes in patients with type 2 diabetes. Side effects of Lipitor include headache, urinary tract infections (UTIs), joint pain, common cold, intestinal gas (flatulence), diarrhea, constipation, and heartburn.
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Statins is a class of drugs prescribed to lower blood cholesterol. Statins also are prescribed for preventing and treating atherosclerosis. Common side effects of statins are
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Serious side effects can occur.
Examples of statins available in the US are
- atorvastatin (Lipitor),
- fluvastatin (Lescol, Lescol XL),
- lovastatin (Mevacor, Altoprev),
- pravastatin (Pravachol),
- rosuvastatin (Crestor),
- simvastatin (Zocor), and
- pitavastatin (Livalo).
Drug interactions, dosing, storage, and pregnancy safety should be reviewed prior to taking this medication.