- What is cerivastatin, and how does it work (mechanism of action)?
- What brand names are available for cerivastatin?
- Is cerivastatin available as a generic drug?
- Do I need a prescription for cerivastatin?
- What are the side effects of cerivastatin?
- What is the dosage for cerivastatin?
- Which drugs or supplements interact with cerivastatin?
- Is cerivastatin safe to take if I'm pregnant or breastfeeding?
- What else should I know about cerivastatin?
What is cerivastatin, and how does it work (mechanism of action)?
Cerivastatin is a drug that lowers cholesterol in the blood by blocking the enzyme in the liver that is responsible for producing cholesterol. It lowers total cholesterol as well as the LDL subfraction of cholesterol in the blood. LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease. Lowering LDL cholesterol levels retards and may even reverse coronary artery disease. Cerivastatin is in the same class of drugs (HMGCoA reductase inhibitors) as atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), lovastatin (Mevacor), and fluvastatin (Lescol). Cerivastatin was approved by the FDA in 1997.
What are the side effects of cerivastatin?
Cerivastatin generally is well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, nasal congestion, and headache. Cerivastatin should be used with caution in patients with alcoholic or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle damage due to inflammation (myositis) have been reported with other drugs in the same class as cerivastatin, and is presumed also to occur with cerivastatin as well. (Muscle inflammation causes the release of muscle protein, myoglobin, into the blood where it is carried to the kidneys and leads to kidney failure.)
What is the dosage for cerivastatin?
Cerivastatin usually is taken once daily at bedtime. It may be taken with or without food.
Which drugs or supplements interact with cerivastatin?
With other drugs in the same class as cerivastatin, the risk of muscle damage (see below) is increased when they are given at the same time as other medications such as cyclosporine (Sandimmune; Neoral), gemfibrozil (Lopid), erythromycin, itraconazole (Sporanox) and nicotinic acid. It is assumed that cerivastatin will interact similarly.
Is cerivastatin safe to take if I'm pregnant or breastfeeding?
It is not known if cerivastatin causes harm to the fetus if taken during pregnancy. Cerivastatin may be used in pregnancy if the physician feels that its benefits outweigh its potential risks.
What else should I know about cerivastatin?
What preparations of cerivastatin are available?
Tablets, 0.3mg, 0.4mg, and 0.8mg.
How should I keep cerivastatin stored?
Tablets should be stored at room temperature, 15-30°C (59-86°F).
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Cholesterol (Lowering Your Cholesterol)
High cholesterol and triglyceride levels increase the risk of cardiovascular disease. Getting your cholesterol and triglyceride levels in an optimal range will help protect your heart and blood vessels. Cholesterol management may include lifestyle interventions (diet and exercise) as well as medications to get your total cholesterol, LDL, HDL, and triglycerides in an optimal range.
Peripheral Vascular Disease
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. While there are many causes of peripheral vascular disease, doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis. Peripheral artery disease symptoms include intermittent leg pain while walking, leg pain at rest, numbness in the legs or feet, and poor wound healing in the legs or feet. Treatment for peripheral artery disease include lifestyle measures, medication, angioplasty, and surgery.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back. Women experience the same symptoms as men; however, they also may experience: Extreme fatigue Pain in the upper abdomen Dizziness Fainting Leading a healthy lifestyle with a heart healthy low-fat diet, and exercise can help prevent heart disease and heart attack.
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Reference: FDA Prescribing Information