- Bacterial Infections 101 Pictures Slideshow
- Take the Tummy Trouble Quiz
- Hepatitis C Slideshow Pictures
Facts on cefdinir vs. cefuroxime
- Cefdinir and cefuroxime (Zinacef, Ceftin) are cephalosporin antibiotics used to treat a range of infections.
- The brand name for cefdinir called Omnicef is discontinued in the U.S.
- Side effects of cefdinir and cefuroxime that are similar include diarrhea or loose stools, nausea, vomiting, abdominal pain, headache, vaginitis, and skin rash.
- Side effects of cefdinir that are different from cefuroxime include vaginal yeast infection, and rarely, abnormal liver tests.
- Rare side effects of cefdinir include abnormal stool, constipation, and dry mouth.
- Side effects of cefuroxime that are different from cefdinir include hives, mouth ulcers. Serious side effects of cefuroxime include allergic reactions, severe skin reactions, anemia, and seizures.
- Both cefdinir and cefuroxime can cause a potentially serious condition called pseudomembranous colitis (Clostridium difficile colitis), a severe bacterial infection of the colon.
- People allergic to the penicillin class of antibiotics may also be allergic to cefdinir or cefuroxime. Serious and rare allergic reactions may include anaphylaxis, seizures, and low red blood cell or platelet counts.
What is cefdinir? What is cefuroxime?
Cefdinir and cefuroxime (Zinacef, Ceftin) are cephalosporin antibiotics used to treat infections cause by susceptible bacteria such as infections of the tonsils (tonsillitis), throat (strep throat), larynx (laryngitis), middle ear (otitis media), sinuses (sinusitis), lungs (pneumonia), bronchi (bronchitis), and skin and other soft tissues. Other cephalosporin antibiotics include cephalexin (Keflex), cefaclor (Ceclor), cefixime (Suprax), cefpodoxime (Vantin), and cefprozil (Cefzil).
What are the side effects of cefdinir and cefuroxime?
- Cefdinir generally is well tolerated. The most common side effects are:
- Rare side effects include:
- Cefdinir may cause false test results with some tests for sugar in the urine.
- Like most antibiotics, cefdinir may cause a condition called pseudomembranous colitis (Clostridium difficile colitis), a potentially serious bacterial infection of the colon.
- Persons who are allergic to the penicillin class of antibiotics, for example, amoxicillin, amoxicillin and clavulanic acid (Augmentin), which are related to cephalosporins, may or may not be allergic to cephalosporins.
Cefuroxime is generally well tolerated, and side effects are usually transient. Commonly reported side effects are:
Other important side effects include:
- Allergic reactions,
- severe skin reactions,
- anemia, and
Since cefuroxime is chemically related to penicillin, patients allergic to penicillin may develop an allergic reaction (sometimes even anaphylaxis) to cefuroxime. Cefuroxime like other antibiotics can alter the colon's normal bacteria, leading to overgrowth of a bacterium called Clostridium difficile. Overgrowth of this bacterium leads to the release of toxins that contribute to the development of Clostridium difficile-associated diarrhea, which may range in severity from mild diarrhea to fatal pseudomembranous colitis.
What is the dosage of cefdinir vs cefuroxime?
- Cefdinir is taken once or twice daily, depending on the type and severity of the infection.
- The capsules or suspension can be taken with or without food.
- Patients with advanced kidney disease may need to take lower doses to prevent accumulation of cefdinir since it is eliminated from the body by the kidneys.
- For adult infections the usual dose is 300 mg every 12 hours or 600 mg per day for 5-10 days depending on the nature and severity of the infection.
- The recommended dose for children 6 months to 12 years of age is 7 mg/kg every 12 hours or 14 mg/kg per day for 5-10 days depending on the type of infection.
- For most infections, once daily dosing is as effective as twice daily dosing, although once daily dosing has not been evaluated for the treatment of skin infections or pneumonia.
- Typical adult oral doses are 250 or 500 mg twice daily for 7-20 days depending on the type and severity of the infection.
- A single 1000 mg dose may used for uncomplicated gonorrhea.
- The tablets and suspension are not interchangeable.
What drugs interact with cefdinir and cefuroxime?
- Aluminum or magnesium containing antacids reduce the absorption of cefdinir from the intestine. Separating the administration of cefdinir and such antacids by two hours prevents this interaction.
- Iron supplements also reduce the absorption of cefdinir. Separating the administration of cefdinir and iron supplements by two hours prevents this interaction. There have been reports of reddish stool in patients who have received cefdinir. This could be due to the formation of a chemical complex between cefdinir and iron in the stomach.
Are cefdinir and cefuroxime safe to use while pregnant or breastfeeding?
- There are no adequate studies of cefdinir in pregnant women; however, studies in animals suggest no important effects on the fetus.
- Cefdinir is not secreted in human milk.
Latest Medications News
Daily Health News
Cefdinir and cefuroxime (Zinacef, Ceftin) are cephalosporin antibiotics used to treat a range of infections. Side effects of cefdinir and cefuroxime that are similar include diarrhea or loose stools, nausea, vomiting, abdominal pain, headache, vaginitis, and skin rash.
Multimedia: Slideshows, Images & Quizzes
Ear Infection Quiz: Test Your Medical IQ
Is it possible to prevent ear infections? Take the Ear Infection (Otitis Media) Quiz to learn the risks, causes, symptoms and...
Do I Have Pneumonia? Symptoms & Signs
Pneumonia can be deadly. Take the Pneumonia Quiz on MedicineNet to learn more about this highly contagious, infectious disease....
Picture of Tonsil Stones
Tonsil stones (also called tonsilloliths) form when bacteria and mucus get trapped and calcify in your tonsils' nooks and...
Picture of Tonsils
The tonsils (palatine tonsils) are a pair of soft tissue masses located at the rear of the throat (pharynx). See a picture of the...
Ear Infection Symptoms, Causes, and Treatment
Learn about the causes and symptoms of ear infections and how they are diagnosed and treated. Read about treatments such as ear...
Related Disease Conditions
Tonsillitis (Adnoiditis, Symptoms, Home Treatment, Pictures, Causes)
Tonsillitis is a contagious infection with symptoms of bad breath, snoring, congestion, headache, hoarseness, laryngitis,...
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness...
Sinus Infection (Sinusitis)
Sinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms...
Group B Strep
Group B strep are bacteria called Streptococcus agalactiae that may sometimes cause infections both in a pregnant woman and her...
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is infection, which...
Is Strep Throat Contagious?
Strep throat is caused by group A streptococcus bacterium. Symptoms of strep throat include sore throat, white patches or spots...
Treatment & Diagnosis
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.