Medically Reviewed on 10/21/2022

Brand Name: Omnicef

Generic Name: cefdinir

Drug Class: N/A

What is cefdinir?

Cefdinir is a prescription semi-synthetic (partially man-made) oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes:

Note: Omnicef brand has been discontinued and there are no other brand names available for cefdinir available in the US

What are the uses for cedinir?

Cefdinir is effective against susceptible bacteria causing infections of the following:

Cefdinir is not active against Pseudomonas.

What are the side effects of cefdinir?


Bowel regularity means a bowel movement every day. See Answer

What is the dosage for cefdinir?

  • Cefdinir is taken once or twice daily, depending on the type and severity of the infection.
  • The capsules or suspension can be taken with or without food.
  • Patients with advanced kidney disease may need to take lower doses to prevent the accumulation of cefdinir since it is eliminated from the body by the kidneys.
  • For adult infections, the usual dose is 300 mg every 12 hours or 600 mg per day for 5-10 days depending on the nature and severity of the infection.
  • The recommended dose for children 6 months to 12 years of age is 7 mg/kg every 12 hours or 14 mg/kg per day for 5-10 days depending on the type of infection.
  • For most infections, once-daily dosing is as effective as twice-daily dosing, although once-daily dosing has not been evaluated for the treatment of skin infections or pneumonia.

Which drugs or supplements interact with cefdinir?

  • Aluminum or magnesium-containing antacids reduce the absorption of cefdinir from the intestine. Separating the administration of cefdinir and such antacids by two hours prevents this interaction.
  • Iron supplements also reduce the absorption of cefdinir. Separating the administration of cefdinir and iron supplements by two hours prevents this interaction. There have been reports of reddish stool in patients who have received cefdinir. This could be due to the formation of a chemical complex between cefdinir and iron in the stomach.
  • Cefdinir has serious interactions with the following drugs:
  • Cefdinir has moderate interactions with at least 25 other drugs.
  • Cefdinir has minor interactions with the following drugs:

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all the products you use.  Keep a list of all your medications with you, and share this information with your doctor and pharmacist.  Check with your healthcare professional or doctor for additional medical advice, or if you have health questions or concerns.

Is cefdinir safe to use during pregnancy or while breastfeeding?

  • There are no adequate studies of cefdinir in pregnant women; however, studies in animals suggest no important effects on the fetus.
  • Cefdinir is not secreted in human milk.

What else should I know about cefdinir?

What preparations of cefdinir are available?
  • Capsules: 300 mg.
  • Oral suspension: 125 and 250 mg/5 mL
How should I keep cefdinir stored?
  • Cefdinir should be stored at room temperature, between 59 F and 86 F (15 C and 30 C).
  • The suspension may be stored at room temperature for up to 10 days after mixing.
How does cefdinir work?
  • Like other cephalosporins, cefdinir stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Cefdinir is active against a very wide spectrum of bacteria, including

Therapeutic uses of cefdinir include otitis media (infections of the middle ear), infections of soft tissues, and respiratory tract infections.

When was cefdinir approved by the FDA?
  • The FDA approved cefdinir in December 1997.


Cefdinir (brand name Omnicef has been discontinued) is an antibiotic used to treat bacterial infections such as strep throat, E. coli, staph infections, streptococcus infections, ear infections, tonsillitis, bronchitis, and pneumonia. The most common side effects include

Drug interactions include antacids that contain aluminum, magnesium, and iron supplements. Dosage, uses, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.

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See more info: cefdinir on RxList
Medically Reviewed on 10/21/2022
Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine


FDA Prescribing Information