- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What is cangrelor, and how does it work (mechanism of action)?
- What brand names are available for cangrelor?
- Is cangrelor available as a generic drug?
- Do I need a prescription for cangrelor?
- What are the uses for cangrelor?
- What are the side effects of cangrelor?
- What is the dosage for cangrelor?
- Which drugs or supplements interact with cangrelor?
- Is cangrelor safe to take if I'm pregnant or breastfeeding?
- What else should I know about cangrelor?
What is cangrelor, and how does it work (mechanism of action)?
- Cangrelor is an anti-platelet drug, that is, a drug
that inhibits the ability of platelets to clump together as part of a blood
clot. Cangrelor prevents
blood clots by
reversibly binding to the P2Y12 receptor on platelets, preventing
diphosphate (ADP) from activating platelets. It belongs to a class of
called P2Y12 inhibitors. Other drugs in this class include
- clopidogrel (Plavix),
- ticagrelor (Brilinta), and
- prasugrel (Effient).
- Cangrelor is different from other P2Y12 inhibitors because it prevents clotting faster and its effect does not last as long after it is stopped. After administration, platelet inhibition begins within 2 minutes, lasts for the duration of the infusion, and platelet function returns to normal within 1 hour after stopping the infusion.
What are the uses for cangrelor?
- Cangrelor is used during percutaneous coronary intervention (PCI) for reducing the risk of heart attacks, repeat coronary revascularization, and stent thrombosis (ST) in patients who have not been treated with another P2Y12 platelet inhibitor and are not receiving a glycoprotein IIb/IIIa inhibitor, another class of platelet inhibitors.
What is the dosage for cangrelor?
- Cangrelor is administered by intravenous (IV) infusion. The recommended dose is a 30 mcg/kg IV bolus before PCI followed immediately by a 4 mcg/kg/min IV maintenance infusion.
- The maintenance infusion should be continued for at least 2 hours or for the duration of PCI, whichever is longer.
Which drugs or supplements interact with cangrelor?
- If clopidogrel or prasugrel are given during cangrelor infusion, they will have no antiplatelet effect until the next dose is given. Therefore clopidogrel and prasugrel should not be given until the cangrelor infusion is stopped.
Is cangrelor safe to take if I'm pregnant or breastfeeding?
- Use of cangrelor in pregnant females has not been adequately studied.
- It is not known whether cangrelor is excreted in human milk.
Cangrelor (Kengreal) is a drug used to reduce the risk of heart attacks during precutaneious coronary intervention, repeat coronary revascularization, and stent thrombosis. Side effects include
Multimedia: Slideshows, Images & Quizzes
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Heart Catheter
Catheter procedures are much easier than surgery on patients because they involve only a needle puncture in the skin where the...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
Lower Your Cholesterol, Save Your Heart
Need to lower your cholesterol levels? Use these smart diet tips to quickly and easily lower your blood cholesterol levels....
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
High-Fiber Super Foods: Whole Grains, Fruits, & More
Learn about high-fiber foods. From fresh fruits to whole grains, these fiber-rich foods can lower cholesterol, prevent...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart...
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management....
12 Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms,...
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures,...
Omega-3 Fatty Acids (Benefits, Uses, Foods)
Omega-3 fatty acids are essential fats that help decrease one's cholesterol and triglyceride levels as well as reduce the risk of...
Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may...
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to...
Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a...
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases...
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women...
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart...
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause...
Treatment & Diagnosis
Medications & Supplements
Healthy Heart Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.