- Type 2 Diabetes: Learn the Warning Signs
- Diabetes Friendly Dining
- Type 2 Diabetes: Test Your Medical IQ
- What is canagliflozin, and how does it work (mechanism of action)?
- What brand names are available for canagliflozin?
- Is canagliflozin available as a generic drug?
- Do I need a prescription for canagliflozin?
- What are the side effects of canagliflozin?
- What is the dosage for canagliflozin?
- Which drugs or supplements interact with canagliflozin?
- Is canagliflozin safe to take if I'm pregnant or breastfeeding?
- What else should I know about canagliflozin?
What is canagliflozin, and how does it work (mechanism of action)?
Canagliflozin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. It is a new type of diabetes medication in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. Under normal conditions, glucose is filtered out of the blood and into the kidney tubules as blood passes through the kidneys. The glucose then as absorbed from the tubules back into the blood so that glucose is not lost in the urine. SGLT2 is an enzyme in the kidney tubule that causes glucose to be reabsorbed from urine. Canagliflozin blocks the action of SGLT2. Therefore, canagliflozin reduces the reabsorption of glucose from renal tubules, leading to more excretion of glucose in urine. Canagliflozin was approved by the FDA in March 2013.
What are the side effects of canagliflozin?
AND PRECAUTIONSThe most common side effects of canagliflozin are:
Other side effects of canagliflozin include:
What is the dosage for canagliflozin?
Canagliflozin should be taken before the first meal of the day. The recommended starting dose is 100 mg once daily and the maximum dose is 300 mg once daily. Renal function should be assessed prior to starting canagliflozin and periodically during treatment, and the dose of canagliflozin should be modified based on renal function.
Which drugs or supplements interact with canagliflozin?
Rifampin, phenytoin (Dilantin, Dilantin-125, phenobarbital, and ritonavir (Norvir) may reduce the effect of canagliflozin by increasing its elimination and reducing its concentration in the body. The dose of canagliflozin should be increased to 300 mg daily when combined with rifampin, phenytoin, phenobarbital, or ritonavir.
Monitoring glucose control with urine glucose tests is not recommended in patients taking canagliflozin and similar drugs. These drugs increase urinary glucose excretion and will lead to positive urine glucose tests. Use alternative methods to monitor glucose control.
Is canagliflozin safe to take if I'm pregnant or breastfeeding?
It is unknown whether canagliflozin is secreted in human breast milk.
What else should I know about canagliflozin?
What preparations of canagliflozin are available?
Tablets: 100 and 300 mg
How should I keep canagliflozin stored?
Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F)
Canagliflozin (Invokana) is a medication prescribed for the treatment of type 2 diabetes in combination with diet and exercise. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
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Treatment & Diagnosis
Medications & Supplements
- glipizide, Glipizide XL, Glucotrol, Glucotrol XL
- metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet)
- Amaryl (glimepiride)
- repaglinide, Prandin
- rosiglitazone, Avandia
- Actos (pioglitazone)
- Precose (acarbose)
- glucose (Insta-Glucose, Dex4, Enfamil Glucose, Glutol, Glutose and many others)
- nateglinide, Starlix
- glipizide and metformin (Metaglip has been discontinued in the US)
- Avandamet (rosiglitazone/metformin)
- Glucovance (glyburide/metformin)
- exenatide, Byetta
- pramlintide, Symlin
- sitagliptin; Januvia
- metformin and sitagliptin (Janumet)
- Victoza (liraglutide)
- Insulin for Diabetes Treatment (Types, Side Effects, and Preparations)
- SGLT2 Inhibitors (Sodium-Glucose Co-Transporter 2)
- Jardiance (empagliflozin)
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.