Can You Develop a Tolerance for Prilosec?

  • Medical Author:
    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical Editor: Dennis Lee, MD
    Dennis Lee, MD

    Dennis Lee, MD

    Dr. Lee was born in Shanghai, China, and received his college and medical training in the United States. He is fluent in English and three Chinese dialects. He graduated with chemistry departmental honors from Harvey Mudd College. He was appointed president of AOA society at UCLA School of Medicine. He underwent internal medicine residency and gastroenterology fellowship training at Cedars Sinai Medical Center.

Ask the experts

I have been taking omeprazole (Prilosec) on and off for 3 years. Of late, there seems to be less relief for my unusual dyspepsia. At times I can feel the acid rushing out as it gives a warm sensation inside my stomach. When I get excessive acid, I experience heart palpitations and become weak. I understand there is a procedure whereby a nerve controlling acid secretion can be deaden to reduce acid secretion. Where can I find more information.

Doctor's response

The nerve that is important in promoting acid secretion by the stomach is the vagus nerve. Operations for treating ulcers in the stomach and duodenum include cutting the vagus nerve (vagotomy) to reduce the secretion of acid by the stomach. (Vagotomy is not used for treating acid reflux.) These operations and vagotomy are performed infrequently now because of the effectiveness of medications like omeprazole (Prilosec) at reducing acid and thereby healing or preventing ulcers.

Medically reviewed by John A. Daller, MD; American Board of Surgery with subspecialty certification in surgical critical care


Functional Dyspepsia.

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Reviewed on 9/18/2017