- Survival Rates
- What Is It
Craniopharyngioma is a benign brain tumor that rarely becomes cancerous. Most people treated for craniopharyngioma are cured (approximately 80%-90% chance).
Treatment involves resection (surgical removal) of the tumor or treating it with high doses of radiation especially if the tumor is not entirely removed due to its location. However, prognosis and cure rates depend on certain factors such as:
- Age of the patient
- Size of the tumor
- Location of the tumor
- Presence of left-over tumor cells post-surgery
- Whether the tumor can be completely removed
- Associated side effects that may occur months or years after treatment
- Whether the tumor has been diagnosed for the first time or has recurred or relapsed
What are the survival rates for craniopharyngioma?
When diagnosed early and managed properly, the 5-year survival rate for children under age 15 with craniopharyngioma is over 95%.
Craniopharyngioma is considered a chronic disease by many experts, however, because of the high tumor recurrence rates even with apparent complete resection of the tumor.
What is a craniopharyngioma?
Craniopharyngioma usually forms at the base of the brain close to the pituitary gland (a pea-sized organ at the bottom of the brain that controls other glands) and does not spread to other areas.
Craniopharyngioma is also known as:
- Rathke’s pouch tumor
- Craniopharyngeal duct tumor
Craniopharyngiomas are typically partly solid mass and partly fluid-filled cyst that can grow and produce pressure on the nearby organs, including the:
- Pituitary gland
- Optic tracts or chiasm (contain the nerve fibers responsible for vision)
- Third ventricle of the brain
What are different types of craniopharyngioma?
- Adamantinomas: Most commonly occur in children and arise from cells from an embryologic structure called craniopharyngeal duct
- Papillary: More common in adults and arise from cells from the anterior part of the pituitary gland
What causes craniopharyngioma?
Although the exact cause of craniopharyngioma is unknown, experts speculate that the tumor grows from leftover pieces of tissue that fail to disappear as expected in early pregnancy when the fetal head, face, and brain are forming.
Though it can affect people of any age, craniopharyngioma most commonly affects children between 5-10 years of age and adults between 50-74 years. All genders are equally likely to develop this type of tumor.
There are no known risk factors for childhood craniopharyngioma.
What are the symptoms of craniopharyngioma?
Craniopharyngioma causes symptoms by:
- Compressing the foramen of Monro within the ventricles, which accumulate the cerebrospinal fluid, resulting in increased pressure on the brain (hydrocephalus)
- Disrupting hormone production by the pituitary gland
- Pressuring or damaging the optic nerve
Increased pressure on the brain can cause:
Other symptoms may include:
- Hearing problems
- Trouble seeing things to the far left and right
- Poor balance or trouble walking
- Increased thirst
- Increased frequency of urination
- Delayed puberty
- Weight gain
- Slow or retarded growth (short stature)
- Delayed menarche
- Excessive tiredness
- Low blood pressure
- Behavioral and learning problems
How is craniopharyngioma diagnosed?
After analyzing your medical history and current symptoms, the doctor will perform a physical examination and recommend certain tests, which may include:
- Blood tests to measure hormone levels
- Imaging tests, such as computed tomography or magnetic resonance imaging scans of the brain
- Neurological examination to check mental status, coordination, ability to walk normally, as well as the muscles, senses, and reflexes
- Visual field examination to check the field of vision (total area in which objects can be seen) which includes both central vision and peripheral vision
Additional tests may include:
- Lumbar puncture (spinal tap): A needle is inserted into the back to withdraw a small amount of cerebrospinal fluid for lab analysis
- Biopsy of a tissue sample:
- Open biopsy: A hollow needle is inserted into a hole in the skull
- Computed tomography (CT)-guided needle biopsy: A CT-guided hollow needle is inserted through a small hole in the skull and into the brain
- Transsphenoidal biopsy: Instruments are inserted through the nose and sphenoid bone (a butterfly-shaped bone at the base of the skull)
How is craniopharyngioma treated?
Surgery is typically the primary treatment for craniopharyngioma. However, for some people, radiation therapy may be the better treatment option.
Depending on the size and location of the tumor, it may be removed through a hole in the skull or the nose.
- Surgery: Removal of the entire or most of the tumor is recommended
- Open craniopharyngioma surgery (craniotomy): Involves opening the skull to gain access to the tumor
- Transsphenoidal procedure: Minimally invasive craniopharyngioma surgery that uses specialized surgical tools inserted through the nose
- Radiation therapy: Uses powerful energy beams, such as X-rays and protons, to kill tumor cells
- Specialized external beam radiation technology, such as proton beam and intensity-modulated radiation therapy (IMRT), allows the radiation beam to target the tumor cells exclusively, sparing nearby healthy tissue
- Stereotactic radiosurgery may be recommended in cases where the tumor is not affecting the optic nerve and the bundle of nerve fibers that transmit visual information from the eyes to the brain
- Chemotherapy: Drug treatment that uses chemicals to kill tumor cells
- Targeted therapy: Drug treatment that primarily focuses on abnormalities within the tumor cells that allows them to survive
- Immunotherapy: Uses the patient’s immune system to fight cancer cells
- Cyst drainage: Involves a surgical procedure to drain tumors that are mostly fluid-filled cysts through a catheter (thin tube)
What are potential complications of craniopharyngioma?
Craniopharyngioma and its treatment can cause physical symptoms and side effects which can be managed with palliative care (including medication, dietary changes, relaxation techniques, emotional and spiritual support, and other therapies) and supportive care.
Side effects may include:
- Physical problems
- Bone and muscle growth and development
- Behavior problems
- Changes in mood, feelings, thinking, learning, or memory
- Secondary cancers
Complications may include:
Subscribe to MedicineNet's General Health Newsletter
KidsHealth. Craniopharyngioma. https://kidshealth.org/en/parents/craniopharyngioma.html
National Institutes of Health. Childhood Craniopharyngioma Treatment. https://www.cancer.gov/types/brain/patient/child-cranio-treatment-pdq
National Organization for Rare Disorders. Craniopharyngioma. https://rarediseases.org/rare-diseases/craniopharyngioma/
Top Can Craniopharyngioma Be Cured Related Articles
Brain Cancer: Tumor Signs, Symptoms, and TreatmentBrain cancer, types of which include primary or secondary cancer, involves invasive brain tumors including gliomas and glioblastomas. Learn the brain cancer survival rate, treatment options including chemotherapy, and the different brain tumor grades. Find out how the right treatment plan can fight cancerous brain tissue.
Can Craniopharyngioma Be Cancerous?Craniopharyngiomas are benign (noncancerous) brain tumors that are slow-growing and unlikely to spread. Only in very rare cases do craniopharyngiomas become cancerous.
Cancer: What Complications Can Brain Cancer Cause?Brain cancer can cause many different complications, from seizures to extreme fatigue. Use this WebMD slideshow to learn how it can affect your body, and what you and your doctor can do about it.
What Were Your First Signs and Symptoms of a Brain Tumor?The symptoms of a tumor depend on how big it is and where it is in the brain. Some slow-growing tumors may not cause any symptoms at first. Eventually, the tumor may put pressure on the brain that may cause the signs and symptoms like severe headaches, seizures, irritability, dizziness, personality change and more.
How Do Brain Tumors Affect the Eyes?Brain tumors can cause vision changes such as blurred vision, double vision, abnormal eye movements, squinting, and restricted field of vision.
Pituitary Gland PictureThe main endocrine gland. See a picture of Pituitary Gland and learn more about the health topic.
Targeted Therapy: What Is Apoptosis in Cancer Cells?Cancer cells grow and proliferate endlessly. Targeted therapy to stimulate cell death or apoptosis can help keep tumors in check. Normal cells have a finite cell cycle of growth, division and differentiation. The final stage in the cell cycle is apoptosis, or programmed cell death, when they are infected, old, damaged or simply no longer needed.
Targeted Therapy: What Is the Function of A Tumor Suppressor Gene?Tumor suppressor genes encode proteins to modulate the process of cell growth and replication. Mutations which inactivate the tumor suppressor genes enable cancer cells to grow, unrestrained. Some targeted therapies aim to reactivate these genes, thus suppressing the tumor.
What Are the Symptoms of Nervous System Cancer?Nervous system or central nervous system (CNS) cancer can cause a wide range of signs and symptoms, which can vary. These symptoms include headaches, seizures, changes in mental function, vision problems, weakness or numbness, difficulty speaking, changes in behavior or personality, balance problems, pain, nausea and vomiting, changes in vision or hearing, swelling in the face or neck, and loss of appetite.
What Is the Most Common Type of Brain Tumor?Meningioma is the most common type of brain tumor and accounts for 30% of all brain tumors. Most are benign and slow-growing.