Brand Name: Camzyos
Generic Name: mavacamten
Drug Class: Cardiac Myosin Inhibitors
What is Camzyos (mavacamten), and what is it used for?
Camzyos (mavacamten) capsules is a prescription medicine used to improve functional capacity and treat the symptoms of New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM). Camzyos may be used alone or with other medications.
Camzyos belongs to a class of drugs called Cardiac Myosin Inhibitors.
It is not known if Camzyos is safe and effective in children.
RISK OF HEART FAILURE
Camzyos reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction.
Echocardiogram assessments of LVEF are required prior to and during treatment with Camzyos. Initiation of Camzyos in patients with LVEF <55% is not recommended. Interrupt Camzyos if LVEF is <50% at any visit or if the patient experiences heart failure symptoms or worsening clinical status.
Concomitant use of Camzyos with certain cytochrome P450 inhibitors or discontinuation of certain cytochrome P450 inducers may increase the risk of heart failure due to systolic dysfunction; therefore, the use of Camzyos is contraindicated with the following:
- Moderate to strong CYP2C19 inhibitors or strong CYP3A4 inhibitors
- Moderate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers
Because of the risk of heart failure due to systolic dysfunction, Camzyos is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called Camzyos REMS Program.
What are the side effects of Camzyos?
Camzyos may cause serious side effects including:
- difficulty breathing,
- swelling of your face, lips, tongue, or throat,
- fainting, and
- reduced left ventricular ejection fraction from the heart
Get medical help right away, if you have any of the symptoms listed above.
The most common side effects of Camzyos include:
Tell the doctor if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Camzyos. For more information, ask your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What are the dosages of Camzyos?
Initiation, Maintenance, and Interruption of Treatment
- Confirm absence of pregnancy and usage of effective contraception in females of reproductive potential.
- Initiation or up-titration of Camzyos in patients with LVEF <55% is not recommended.
- The recommended starting dose is 5 mg once daily without regard to food; allowable subsequent doses with titration are 2.5, 5, 10, or 15 mg once daily.
- Patients may develop heart failure while taking Camzyos. Regular LVEF and Valsalva left ventricular outflow tract (LVOT) gradient assessment is required for careful titration to achieve an appropriate target Valsalva LVOT gradient, while maintaining LVEF ≥50% and avoiding heart failure symptoms (see Figure 1 and Figure 2).
- Daily dosing takes weeks to reach steady-state drug levels and therapeutic effects, and genetic variation in metabolism and drug interactions can cause large differences in exposure.
- When initiating or titrating Camzyos, first consider LVEF then consider the Valsalva LVOT gradient and patient clinical status to guide appropriate Camzyos dosing.
- Follow the algorithms for Initiation (Figure 1) and Maintenance (Figure 2) for appropriate Camzyos dosing and monitoring schedules.
- If LVEF <50% while taking Camzyos, interrupt treatment. Follow the algorithm for Interruption (Figure 3) for guidance on interrupting, restarting, or discontinuing Camzyos. If interrupted at 2.5 mg, either restart at 2.5 mg or discontinue permanently.
Figure 1: Initiation Phase
Initiation Phase - Illustration
Figure 2: Maintenance Phase
Maintenance Phase - Illustration
Figure 3: Treatment Interruption at Any Clinic Visit if LVEF <50%
Maintenance Phase - Illustration
- Delay dose increases when there is intercurrent illness (e.g., serious infection) or arrhythmia (e.g., atrial fibrillation or other uncontrolled tachyarrhythmia) that may impair systolic function. Consider interruption of Camzyos in patients with intercurrent illness.
Missed Or Delayed Doses
- If a dose is missed, it should be taken as soon as possible, and the next scheduled dose should be taken at the usual time the following day. Exact timing of dosing during the day is not essential, but two doses should not be taken on the same day.
- Swallow capsules whole. Do not break, open, or chew the capsules.
Concomitant Administration Of Weak CYP2C19 Or Moderate CYP3A4 Inhibitors
- Initiate Camzyos at the recommended starting dosage of 5 mg orally once daily in patients who are on stable therapy with a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor.
- Reduce dosage of Camzyos by one level (i.e., 15 → 10 mg; 10 → 5 mg; or 5 → 2.5 mg) in patients who initiate a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor.
- Schedule clinical and echocardiographic assessment 4 weeks after inhibitor initiation, and do not up-titrate Camzyos until 12 weeks after inhibitor initiation.
- Avoid initiation of concomitant weak CYP2C19 and moderate CYP3A4 inhibitors in patients who are on stable treatment with 2.5 mg of Camzyos because a lower Camzyos once-daily dose is not available.
What drugs interact with Camzyos?
Potential For Other Drugs To Affect Plasma Concentrations Of Camzyos
- Mavacamten is primarily metabolized by CYP2C19 and to a lesser extent by CYP3A4 and CYP2C9. Inducers and inhibitors of CYP2C19 and moderate to strong inhibitors or inducers of CYP3A4 may affect the exposures of mavacamten. (See Table 1)
Table 1: Established and Potentially Significant Pharmacokinetic Drug Interactions with Camzyos
Impact Of Other Drugs On Camzyos
|Moderate to Strong CYP2C19 Inhibitors or Strong CYP3A4 Inhibitors|
|Clinical Impact||Concomitant use with a moderate to strong CYP2C19 or a strong CYP3A4 inhibitor increases mavacamten exposure, which may increase the risk of heart failure due to systolic dysfunction.|
|Prevention or Management||Concomitant use with a moderate to strong CYP2C19 inhibitor or a strong CYP3A4 inhibitor is contraindicated.|
|Moderate to Strong CYP2C19 Inducers or Moderate to Strong CYP3A4 Inducers|
|Clinical Impact||Concomitant use with a moderate to strong CYP2C19 inducer or a moderate to strong CYP3A4 inducer decreases mavacamten exposure, which may reduce Camzyos’ efficacy. The risk of heart failure due to systolic dysfunction may increase with discontinuation of these inducers as the levels of induced enzyme normalizes.|
|Prevention or Management||Concomitant use of a moderate to strong CYP2C19 inducer or a moderate to strong CYP3A4 inducer is contraindicated.|
|Weak CYP2C19 Inhibitors or Moderate CYP3A4 Inhibitors|
|Clinical Impact||Concomitant use with a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor increases mavacamten exposure, which may increase the risk of adverse drug reactions.|
|Prevention or Management||
Initiate Camzyos at the recommended starting dosage of 5 mg orally once daily in patients who are on stable therapy with a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor.
Reduce dose of Camzyos by one level (i.e., 15 to 10 mg, 10 to 5 mg, or 5 to 2.5 mg) in patients who are on Camzyos treatment and intend to initiate a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor. Avoid initiation of concomitant weak CYP2C19 and moderate CYP3A4 inhibitors in patients who are on stable treatment with 2.5 mg of Camzyos because a lower dose is not available.
Potential For Camzyos To Affect Plasma Concentrations Of Other Drugs
- Mavacamten is an inducer of CYP3A4, CYP2C9, and CYP2C19. Concomitant use with CYP3A4, CYP2C19, or CYP2C9 substrates may reduce plasma concentration of these drugs. Closely monitor when Camzyos is used in combination with CYP3A4, CYP2C19, or CYP2C9 substrates where decreases in the plasma concentration of these drugs may reduce their activity.
- Progestin and ethinyl estradiol are CYP3A4 substrates. Concomitant use of Camzyos may decrease exposures of ethinyl estradiol and progestin, which may lead to contraceptive failure or an increase in breakthrough bleeding. Advise patients to use a contraceptive method that is not affected by CYP450 enzyme induction (e.g., intrauterine system) or add nonhormonal contraception (such as condoms) during concomitant use and for 4 months after the last dose of Camzyos.
Drugs That Reduce Cardiac Contractility
- Expect additive negative inotropic effects of Camzyos and other drugs that reduce cardiac contractility. In the EXPLORER-HCM trial, 119 of 123 patients who received Camzyos received concomitant therapy with beta blockers (n=94), verapamil (n=19), or diltiazem (n=6).
- Avoid concomitant use of Camzyos with disopyramide in combination with verapamil or diltiazem because such use has been associated with left ventricular systolic dysfunction and heart failure symptoms.
- If concomitant therapy with a negative inotrope is initiated, or if the dose of a negative inotrope is increased, monitor LVEF closely until stable doses and clinical response have been achieved.
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Pregnancy and breastfeeding
- There are no human data on the use of Camzyos during pregnancy to evaluate for a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.
- The underlying maternal condition during pregnancy poses a risk to the mother and fetus. Advise pregnant females about the potential risk to the fetus with maternal exposure to Camzyos during pregnancy.
- The presence of mavacamten in human or animal milk, the drug's effects on the breastfed infant, and the effects on milk production are unknown.
- The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Camzyos and any potential adverse effects on the breastfed child from Camzyos or from the underlying maternal condition.
Camzyos (mavacamten) is a prescription medication used to treat the symptoms of obstructive hypertrophic cardiomyopathy (HCM). Camzyos reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction. Camzyos may cause serious side effects including hives, difficulty breathing, swelling of your face/lips/tongue/throat, fainting, and reduced left ventricular ejection fraction from the heart. Consult your doctor before taking Camzyos if pregnant or breastfeeding.
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Heartburn symptoms may indicate a bigger health concern. Learn more about heartburn, heartburn symptoms, heartburn related to other health conditions, how it's diagnosed, and your treatment options for heartburn.
Can Cashew Nuts Cause Heartburn?
Although not a major cause, nuts, such as cashews, can trigger heartburn in some individuals. Nuts, including cashews, are high in fats, which slow down the emptying stomach.
Heartburn vs. Acid Reflux (Differences and Similarities)
Heartburn and acid reflux are not the same thing. Heartburn is actually a symptom of acid reflux. Heartburn gets its name because it feels like a burning sensation around the heart. Another symptom that occurs with heartburn is a bitter or sour taste in the mouth, usually when you eat or lye down. Heartburn affects more than 60 million people in the US at least once a month. Acid reflux, or GERD, occurs when stomach acid backs up into the esophagus, which irritates it. Heartburn is just one symptom of acid reflux. Other symptoms of acid reflux include: Belching Nausea after eating A feeling of fullness during or after eating Abdominal bloating Upset stomach Belching Wheezing Reflux laryngitis A tightness in the throat Problems swallowing Indigestion In some people, vomiting Causes of acid reflux and heartburn include: Being obese Slouching (poor posture) Medications like calcium channel blockers, theophylline, nitrates, and antihistamines Foods and drinks like caffeine, citrus fruits and vegetables, alcohol, and chocolate Pregnancy Diabetes Increase in stomach acid Eating a heavy meal Eating before bed The treatment for heartburn and acid reflux is to treat the underlying cause, for example, GERD, with over-the-counter (OTC) medicine, prescription medicine, natural remedies, and lifestyle changes like a eating a healthy, less fatty, spicy diet, not eating big meals, not eating before bed, and getting regular exercise to improve your posture.Sometimes a heart attack can mimic heartburn and acid reflux because they feel very similar. If you have symptoms of chest pain, tightness in the chest, heartburn, acid reflux, jaw, tooth, or head pain; shortness of breath, nausea, vomiting, sweating, discomfort in the upper middle of the abdomen, arm or upper back pain, or the general feeling of being ill, go to the nearest Emergency Department immediately because these are the symptoms of a heart attack.REFERENCES:American College of Gastroenterology. "Acid Reflux." 2017.<http://patients.gi.org/topics/acid-reflux/> familydoctor.org. "Heartburn." Updated: Mar 2014.<https://familydoctor.org/condition/heartburn/> National Library of Medicine; PubMed Health. "Heartburn and GERD: Treatment options for GERD." Updated: Nov 18, 2015.<https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072436/>
What Does a Leaky Heart Valve Feel Like?
Many healthy people may have one or more valves that are slightly leaky, which do not cause any problems. The severity of the symptoms depends on the severity of the heart valve leak.
How Long Does It Take to Recover From a Heart Attack?
While it takes most people about 6-8 months to recover after a heart attack, overall recovery time depends on your general health, how severe the attack was, the type of treatment you received and when you received it.
How Serious Is a Heart Catheterization?
Cardiac catheterization is a minimally invasive procedure that is considered to be safe for most patients. The procedure helps doctors find and fix any heart problems. It is a low-risk procedure and complications are usually rare, but as with any procedure, complications may arise.
Dilated cardiomyopathy causes the heart muscles to progressively enlarge and weaken, reducing the ability of the heart to pump enough blood. Check out the center below for more medical references on heart disease, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
What Are the Differences Between Heart Attack, Cardiac Arrest and Stroke?
Heart attack, stroke, and cardiac arrest are severe medical conditions (emergencies) that need immediate medical treatment. Learn the differences between a heart attack, cardiac arrest, and stroke below.
What Causes Congestive Heart Failure?
Congestive heart failure is a chronic disease that progresses with time if left untreated. Heart failure can occur due to diseases of the heart, the blood vessels supplying oxygen and nutrients to the heart, or sometimes from factors outside the heart (extracardiac causes). With proper management, people who have congestive heart failure can lead nearly normal lives, depending on the severity of the condition.
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women and health professionals are not aware of the risk factors for heart disease in women and may delay diagnosis and treatment. Lifestyle factors such as diet, exercise, tobacco use, overweight/obesity, stress, alcohol consumption, and depression influence heart disease risk in women. High blood pressure, high cholesterol, and diabetes also increase women's risk of heart disease. Electrocardiogram (EKG or ECG), stress-ECG, endothelial testing, ankle-brachial index (ABI), echocardiogram, nuclear imaging, electron beam CT, and lab tests to assess blood lipids and biomarkers of inflammation are used to diagnose heart disease. Early diagnosis and treatment of heart disease in women saves lives. Heart disease can be prevented and reversed with lifestyle changes.
When Should You Worry About an Irregular Heartbeat?
Irregular heartbeat is common and in most cases resolves on its own. However, persistent arrhythmia can sometimes be life-threatening.
What Are the Symptoms of a Heart Attack in Women?
Many women think that the typical signs of a heart attack like crushing chest pain and shortness of breath can be easily recognized and cannot be missed. The 4 silent signs of a heart attack are fatigue, chest pain, pain in the upper back, shoulder, arms, neck or jaw, and sleep disturbances.
Quick Relief For Heartburn
Heartburn refers to the burning sensation in the chest due to backflow or reflux of the acidic stomach contents into the food pipe (esophagus). If you are experiencing heartburn, you may ease the problem through various ways.
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures, and illustrations of diseased heart tissue and the mechanisms that lead to coronary artery disease, and possible heart attack. A coronary artery occlusion may be fatal, but most patients survive it. Death can occur when the occlusion leads to an abnormal heartbeat (severe arrhythmia) or death of heart muscle (extensive myocardial infarction).
How Do You Prevent Heartburn When Exercising?
Exercise is an excellent way to lose weight, which is one of the causes of heartburn. However, some people may experience heartburn after exercise or during a workout. There are six tips that may help you ease exercise heartburn.
What are the Most Common Causes of Atrial Fibrillation?
Atrial fibrillation (AF) is an abnormal heart rhythm characterized by an irregular and fast heartbeat. The upper chambers of the heart (atria) beat chaotically, and can cause pooling and clotting of blood in the atria, instead of it emptying into the lower chamber (ventricles). AF can lead to stroke, heart failure, blood clots, and heart-related complications. Atrial fibrillation is classified into three types: Paroxysmal atrial fibrillation, persistent atrial fibrillation, and long-standing persistent atrial fibrillation.
At What Age Does Hypertrophic Cardiomyopathy Develop?
Hypertrophic cardiomyopathy or HCM is a medical condition that causes thickening of the heart muscles (the myocardium). It is a serious disorder that adversely affects the pumping of the heart and makes it prone to an abnormal rhythm. HCM is the most common cause of sudden cardiac death in individuals aged less than 30 years.
What Is a Widowmaker Heart Attack?
A Widowmaker is a type of heart attack, which is deadlier than most others. A widowmaker heart attack occurs when the left ascending artery (LAD) that supplies blood to the front part of the heart (largest part) is clogged-up because of clots in the arterial wall. This causes the death of heart muscle in this area, medically termed myocardial infarction. Because the widowmaker damages a major portion of the heart, timely management is necessary to prevent fatalities.
How Do You Strengthen Your Heart After Heart Failure?
You can strengthen your heart after heart failure by making recommended changes to your diet, exercising regularly, and adopting healthy habits.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back.
What Home Remedies Kill Heartburn?
Heartburn can cause an uncomfortable burning sensation in the chest. Here are 15 natural remedies to relieve heartburn and alleviate symptoms.
How Much Does Treatment for Heart Disease Cost?
Treatment costs for heart disease depend on the type of treatment, doctors, hospitals, and insurance plans. The cost could be a couple of hundred dollars for medication and $20,000 (USD) for surgery.
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases blood pressure, blood clots, and damages coronary arteries. Learn how to quit smoking today, to prolong your life.
How Do You Stop Heartburn Instantly?
Heartburn happens when your esophagus becomes irritated due to stomach acid. You can stop heartburn instantly with over-the-counter medications like antacids.
What Foods Are Good to Treat Heart Failure?
If you have mild-to-moderate heart failure, you may lead a nearly normal life by making some lifestyle changes. Foods that are good to treat heart failure include fruits, vegetables, whole grains, low-fat protein, nuts, legumes, and unsaturated fats.
Restrictive cardiomyopathy, the rarest form of cardiomyopathy, is a condition in which the walls of the lower chambers of the heart (the ventricles) are abnormally rigid and lack the flexibility to expand as the ventricles fill with blood. The pumping or systolic function of the ventricle may be normal but the diastolic function (the ability of the heart to fill with blood) is abnormal. Therefore, it is harder for the ventricles to fill with blood, and with time, the heart loses the ability to pump blood properly, leading to heart failure.
How Serious Is Dilated Cardiomyopathy?
Dilated cardiomyopathy is a serious condition because it increases the chances of life-threatening conditions, such as heart failure, irregular heartbeats (arrhythmias), and blood clots. Dilated cardiomyopathy is the most common type of cardiomyopathy. In this condition, the walls of the heart become thin and the heart gets larger.
When Should I Be Worried About Heart Palpitations?
You should be worried about heart palpitations if they are accompanied by dizziness, lightheadedness, confusion, chest pain, shortness of breath, nausea, vomiting, and more.
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart Association. Risk factors and symptoms of heart disease in women differ from those in men. Treatment may include lifestyle modification (diet, exercise, weight management, smoking cessation, stress reduction), medications, percutaneous intervention procedure (PCI), and coronary artery bypass grafting (CABG). Heart disease is reversible with treatment.
What Are the First Signs of a Heart Attack in a Woman?
A heart attack happens when a blocked artery prevents blood from reaching your heart. Some people, especially women, may have a heart attack without any chest pain or pressure, but may experience chest tightness and aching.
How Can Anger Hurt My Heart?
Anger is a natural emotion, but frequently getting angry can trigger many physiological changes in your body such as increased heart rate and blood pressure, tightening of blood vessels, and increased clotting.
What Causes Hypertrophic Cardiomyopathy?
Hypertrophic cardiomyopathy (HCM) is a condition in which heart muscle becomes thickened affecting its function. Causes of HCM include genetic defects. Researchers are still learning why some people with genetic changes develop the disease and others don’t. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.
When Should You Worry About Heartburn?
Heartburn is usually not a cause for concern. However, if the pain is persistent or frequent, it could be a sign of something more serious. Here are signs to look out for.
Can You Survive Broken Heart Syndrome?
Most people who suffer from broken heart syndrome can achieve a full recovery with proper medical diagnosis and care. However, about four percent of people with the illness die as a result of it.
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are interconnected and affect your risk for heart disease or heart attack. For better heart health, avoid the following fried foods, hard margarine, commercial baked goods, most packaged and processed snack foods, high fat dairy, and processed meats such as bacon, sausage, and deli meats.
Can Angina Lead to a Heart Attack?
Angina, or angina pectoris, is a sudden chest pain caused by low blood flow to the heart. Yes, some types of angina attacks can lead to heart complications.
Can Congenital Heart Defects Be Cured?
Congenital heart disease or a congenital heart defect is a medical condition that is present in an individual at birth. There are different types of congenital heart defects, ranging from simple conditions that don’t cause symptoms to complex ones that cause severe, life-threatening symptoms.
Can You Still Exercise With Heart Failure?
Performing light to moderate exercises is a great way to strengthen your heart muscles after being diagnosed with heart failure.
What Heart Rate Is Bradycardia?
Most researchers consider bradycardia to be a heart rate less 60 beats per minute (bpm).
What Is the Most Common Cause of Atrial Fibrillation (AFib, AF)?
Atrial fibrillation (AFib or AF) refers to abnormal heart rhythm (arrhythmia) that causes quivering or irregular heartbeats. It is a serious medical condition that may further lead to stroke and heart failure. The heart is a muscular organ roughly the size of a closed fist. It has two upper chambers called atria and two lower chambers called ventricles. The flow of blood into the heart, within the heart chambers, and from the heart is guarded by the four valves present in the heart.
What Gets Rid of Heartburn Fast?
Learn what causes heartburn and how to get rid of heartburn fast.
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause of heart failure. The process of developing atherosclerosis (hardening of the arteries) begins early in life. Heart attack prevention should begin in childhood because the atherosclerosis process can not be reversed. The risk of having a heart attack increases if you have diseases or conditions such as high blood pressure, diabetes, and other heart conditions.
Can Peripheral Artery Disease Affect the Heart?
Peripheral artery disease is a condition in which extremities (usually the legs) do not receive sufficient blood flow due to the narrowing of or blocks in arteries. Peripheral artery disease is also likely to be a sign of more widespread accumulation of fat deposits in the arteries (atherosclerosis or plaque).
Is It Bad to Have an Irregular Heartbeat?
Irregular heartbeat is common and in most cases resolves on its own. However, persistent arrhythmia can sometimes be life-threatening.
How Can I Take Care of My Heart at Home?
Heart disease is one of the leading causes of death in many countries. Keeping the heart healthy no matter how old you are may limit heart diseases and complications.
Does COVID-19 Affect My Heart?
As per the American Heart Association, COVID-19 may have a long-term effect on the heart. Having a heart condition doesn't make a person more likely to catch COVID-19, but an individual with heart disease or a serious heart condition is more likely to become severely ill from COVID-19 and has a higher risk of death.
Can You Have Sex Right After a Heart Attack?
It is important not to put any pressure on yourself or your heart after heart attack. Initially, you might feel less interested in sex. That is perfectly normal, and the feeling goes away quickly.
How Do You Know If You Have Heartburn When Pregnant?
Heartburn is a common issue that affects many pregnant people. Learn the signs of heartburn in pregnancy, what causes it, how doctors diagnose it, and what you can do to treat it.
What Does a Sudden Heart Attack Feel Like?
In most cases, a sudden heart attack may feel like pain, pressure, fullness, or squeezing in the chest that lasts for a few minutes or goes away and comes back.
Can Kawasaki Disease Cause Heart Failure?
Approximately 50 percent of children with Kawasaki disease may develop inflammation of the heart muscle and potentially heart failure, in severe cases.
How Does Sleep Affect Your Heart?
Sleep is an important part of your body's functions. Getting too little or too much sleep can have a negative impact on your heart.
Treatment & Diagnosis
- What Are The Four Heart Sounds?
- How Long Does It Take to Recover From Heart Ablation Surgery?
- How Long Can You Live After a Heart Transplant?
- Can Atrial Fibrillation Go Away?
- What Is the Best Treatment for Atrial Fibrillation?
- How Serious Is a Heart Ablation Surgery?
- What Foods Trigger Atrial Fibrillation?
- How Is Coronary Heart Disease Diagosed?
- What Is a Heart Transplant?
- What Happens During A Video EEG Test?
- Heart Valve Disease Surgery
- How Long Does It Take to Recover from A Transradial Heart Catheterization?
- What Is Ventriculoatrial Shunt Placement?
- What Is PDA Heart Surgery?
- Electroencephalogram (EEG)
- Percutaneous Closure of Patent Foramen Ovale and Atrial Septal Defect
- How Dangerous Is Percutaneous Heart Valve Replacement Surgery?
- Heart CT Scan
- What Is a Video EEG Test?
- What Is a Transradial Heart Catheterization Procedure?
- Heart Lead Extraction
- Enlarged Heart
- Gastroesophageal Reflux Disease (GERD)
- Heart Attack in Women
- Exercising for a Healthier Heart -- Kenneth Cooper, MD -- 02/19/03
- Atrial Fibrillation (AFib)
- Atrial Flutter
- Congenital Heart Defect
- Heart Health: Conquering the #1 Killer with Larry King
- Cooking, Healthy Hearts: At Home with the Hellers
- Heart Disease
- Heartburn (GERD) Dialogue
- Heart Valve Disease
- Heart Attack in Men
- Heart Murmur
- Heart Failure
- Heart Disease, Living Well with
- Heart Disease: Nonsurgical Treatments
- Heart Rhythms: Treating Life-Threatening
- Heart Disease: Preventing Heart Disease in Women
- Heartburn (GERD) Drugs: A New Caution
- Heart Disease in Women
- Heart: The Smart Heart
- GERD: Putting Out the Fire of Heartburn
- Atrial Fibrillation: Surgical Treatments
- Women and Heart Disease
- Heart: Getting Your Heart in Synch
- Women's Heart Health -- Nina Radford, MD
- Heart: Sudden Cardiac Death
- Heart: Caring for Your Heart
- Diabetes and Your Heart
- Heart Disease FAQs
- Sudden Cardiac Arrest Death FAQs
- Atrial Fibrillation A-Fib FAQs
- Heart Failure FAQs
- Broken Heart Syndrome Takotsubo Cardiomyopathy FAQs
- Heart Attack: A Tale of Two Heart Attacks
- Heart Failure: What Killed George Carlin?
- Elizabeth Taylor Dies of Congestive Heart Failure
- Beta Carotene Supplements Not the Answer for Cancer or Heart Disease
- Apoptosis - Affects The Heart
- Chest Pain: Heart, Esophagus, or ?
- Heart Disease Risks Reduced With Running
- Heart Attack - New Blood Test For Earlier Accurate Diagnosis
- Beta Blockers May Decrease Heart Complications Of Surgery
- Cancer,Stroke & Heart Attack Risks- ReducedThrough Walking
- Heart Health- Little Aspirin A Day Stops Big Heart Attack!
- Esophageal Cancer Linked to Heartburn
- Cigar Smoking ... Heart & Lung Disease & Cancer
- Heart Failure ... Old Drug, New Therapy
- Heart Risks - Reduced By Walking & Vigorous Exercise
- Heart Disease In Women
- Ramipril, Heart Disease, Stroke & Diabetes
- Heart Atrial Fibrillation - Bill Bradley
- Translating Medical Research - Preventing Sudden Heart Death
- Heart Disease & Stroke - Progress
- Heartburn Diagnosis
- Heartburn or Heart Attack? Emergency In Flight
- Proven measures to prevent heart attacks and strokes?
- Any promising measures that may prevent heart attacks?
- Heart Disease Stroke and Diabetes
- Heart of Dick Cheney - Another Angioplasty
- Hyperthyroidism...The Heart of the Matter
- Exercise Therapy in Type 2 Diabetes - Part 1
- GERD: Questions To Ask Your Doctor About GERD (Heartburn)
- ARBs and ACE Inhibitors..Hidden Benefits
- Heartburn: Is Heartburn Inherited?
- Heart Disease - Lessons Learned From Pitcher's Early Death
- FLAP Doubles Risk of Heart Attack
- Clinton Headed to Heart Surgery
- The Cox-2 Inhibitors Controversy: Q&A with Dr. Shiel
- Heart Disease: Antioxidant Supplements and Women
- Heart Disease Risk and C-reactive Protein (CRP)
- Hormone Therapy and and Heart Disease in Women
- Heart Attack Prevention From a Doctor's Perspective
- Heart Attack Risk and Medicated Stents
- Avandia - Is It a Heart Risk?
- Doctors Answer Heart Health Questions
- What Should Cholesterol Levels Be After Heart Attack?
- What are The Complications of Rheumatic Heart Disease?
- Are Tums or Rolaids Good for Heartburn?
- How Do You Check for Congestive Heart Failure?
- Do Women Have Different Heart Attack Symptoms?
- Can I Still Get Heart Disease if I Take Blood Pressure Medication?
- Is Red Meat Bad for Your Heart?
- Will My Diet Slip Increase the Risk of Heart Attack?
- How Serious Is Atrial Fibrillation?
- Can Asthma Cause a Heart Attack?
- Does Hashimoto's Affect Heart Disease and Osteoporosis?
- What Causes Hearing Heartbeat in Ears?
- Ibuprofen May Block Aspirin's Heart Benefits
- Heart Disease Prevention in Women
- Congestive Heart Failure Treatment
- Congestive Heart Failure Symptoms
- Heartburn: Carbonated Soda & Sleeping Pills Increase Nighttime Heartburn
- Heart Health: Choose to Move for a Healthy Heart
- Heart Healthy Diet: Hypertension & Heart Disease
- Fen-Phen Heart Hazard
Medications & Supplements
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