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- What is buspirone (Buspar)? How does it work (mechanism of action)?
- What are the uses for buspirone?
- What are the side effects of buspirone?
- What is the dosage for buspirone?
- Which drugs or supplements interact with buspirone?
- Is buspirone safe to take if I'm pregnant or breastfeeding?
- What else should I know about buspirone?
What is buspirone (Buspar)? How does it work (mechanism of action)?
Buspirone is a medication that is used for the treatment of anxiety. Its mechanism of action is not clearly understood but may involve effects on neurotransmitters, chemicals that nerves use to communicate with one another. Serotonin and dopamine are two of these neurotransmitters. Buspirone may work by stimulating serotonin type 1A receptors on nerves, thereby altering the chemical messages that nerves receive. It also has minor effects on dopamine receptors but this does not contribute much to its action. Unlike medications for anxiety of the benzodiazepine class, for example, diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), and clonazepam (Klonopin), buspirone does not cause sedation.
What are the uses for buspirone?
Buspirone is used for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Buspirone is especially effective in persons with generalized anxiety of a limited or moderate degree. It is not very effective in persons with severe anxiety, panic disorders, or obsessive-compulsive disorders.
What are the side effects of buspirone?
The most common side effects associated with buspirone are:
Other important but less frequent side effects include
What is the dosage for buspirone?
The usual starting adult dose is 10-15 mg daily given in 2 or 3 doses. The dose may be increased by 5 mg every 2 to 4 days until an effective dose is found. The maximum adult dose is 60 mg daily, but most patients respond to 15-30 mg daily. Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear. Buspirone can be taken with or without food but preferably on a consistent basis.
Which drugs or supplements interact with buspirone?
Buspirone may interact with drugs called monoamine oxidase (MAO) inhibitors, such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) which are used in psychiatric disorders. The use of buspirone with these drugs can cause increased blood pressure. A similar reaction may occur if buspirone is combined with linezolid (Zyvox), an antibiotic that is also an MAO inhibitor. The combination of buspirone and trazodone (Desyrel), an antidepressant, may cause abnormal liver enzymes in the blood.
The combination of buspirone and warfarin (Coumadin), a blood thinner, may accentuate the effects of warfarin and increase the risk of bleeding. Patients taking buspirone should not drink grapefruit juice, since the juice (even well after a dose of buspirone is taken) can increase the amount of buspirone in the blood, possibly leading to side effects.
Inactivation and removal of buspirone is mediated by liver enzymes. Drugs (for example, erythromycin, itraconazole [Sporanox], nefazodone [Serzone]) that inhibit these liver enzyme increase blood concentrations of buspirone, and drugs (for example, rifampin) that enhance these enzymes decrease blood concentrations of buspirone. Increased blood concentrations may increase side effects while decreased blood concentrations may reduce efficacy.
Is buspirone safe to take if I'm pregnant or breastfeeding?
What else should I know about buspirone?
What preparations of buspirone are available?
Tablets: 5, 10, 15 and 30 mg.
How should I keep buspirone stored?
Tablets should be kept at room temperature, less than 30 C (86 F).
Buspirone is available as a generic drug, by prescription only.
The FDA approved buspirone in September, 1986.
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Buspirone (Buspar is Discontinued brand in the US) is a medication prescribed for the treatment the short-term symptoms of anxiety, especially in people with limited or moderate generalized anxiety. Researchers do not know exactly how buspirone works (mechanism of action), but they believe it involves neurotransmitters in the brain. Busipirone not very effective in individuals with panic disorders, severe anxiety, or OCD.
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Related Disease Conditions
Depression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating, increased gas (flatulence), abdominal cramping, diarrhea, constipation, and food intolerance.Two new tests are now available that may help diagnose irritable bowel syndrome with diarrhea and constipation (IBS-M) irritable bowel syndrome with diarrhea (IBS-D), and irritable bowel syndrome with constipation (IBS-C). Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Panic attacks are sudden feelings of terror that strike without warning. These episodes can occur at any time, even during sleep. A person experiencing a panic attack may believe that he or she is having a heart attack or that death is imminent. The fear and terror that a person experiences during a panic attack are not in proportion to the true situation and may be unrelated to what is happening around them. Most people with panic attacks experience several of the following symptoms: racing heartbeat, faintness, dizziness, numbness or tingling in the hands and fingers, chills, chest pains, difficulty breathing, and a feeling of loss or control. There are several treatments for panic attacks.
Obsessive Compulsive Disorder (OCD)
Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions. Symptoms include irresistible impulses despite a person's realization that the thoughts are irrational, excessive hand washing, skin picking, lock checking, or repeatedly rearranging items. People with OCD are more likely to develop trichotillomania, muscle or vocal tics, or an eating disorder. Treatment for OCD includes psychotherapy, behavioral therapy, and medication.
Mental health is an optimal way of thinking, relating to others, and feeling. All of the diagnosable mental disorders fall under the umbrella of mental illness. Depression, anxiety, and substance-abuse disorders are common types of mental illness. Symptoms and signs of mental illness include irritability, moodiness, insomnia, headaches, and sadness. Treatment may involve psychotherapy and medication.
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
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