- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is bumetanide, and how does it work (mechanism of action)?
- Is bumetanide available as a generic drug?
- Do I need a prescription for bumetanide?
- What are the side effects of bumetanide?
- What is the dosage for bumetanide?
- Which drugs or supplements interact with bumetanide?
- Is bumetanide safe to take if I'm pregnant or breastfeeding?
- What else should I know about bumetanide?
What is bumetanide, and how does it work (mechanism of action)?
Bumetanide is a potent diuretic (water pill) that causes a profound increase in urine output (diuresis) by preventing the kidney from retaining fluid. Specifically, it blocks the reabsorption of sodium and fluid from the kidney's tubules. It is in a class of diuretics called "loop" diuretics which also includes furosemide (Lasix) and torsemide (Demadex). One mg of bumetanide is approximately equivalent to 10-20 mg of torsemide and 40 mg of furosemide. The potent diuretic effect of bumetanide can cause the loss of large amounts of body water leading to dehydration as well as the loss of electrolytes (for example, sodium, potassium, magnesium, and calcium). Therefore, careful medical supervision is necessary during treatment. Bumetanide was approved for use by the FDA in 1983.
What are the side effects of bumetanide?
Potent diuretics like bumetanide can cause low blood levels of potassium, magnesium, sodium and calcium. Additionally, fluid losses can occur leading to dehydration.
The symptoms of dehydration may include:
- dry mouth,
- reduced kidney function,
- heart arrhythmias,
- muscle aches and pains,
- nausea, and
Toxicity to the inner ear in the form of tinnitus (ringing in the ear) and hearing loss have been associated with loop diuretics. High plasma levels of bumetanide are toxic to the inner ear of animals. These effects on the inner ear are far more common with intravenous use of the drugs. High uric acid concentrations in the blood leading to attacks of gouty arthritis may occur during diuretic therapy.
What is the dosage for bumetanide?
The dose for most patients is 0.5 to 2 mg daily by mouth. Doses may be increased every 4 to 5 hours to a maximum dose of 10 mg daily. Intravenous (IV) or intramuscular (IM) injections may be used in place of tablets when oral administration is not possible. The IV dose is 1 mg initially followed by 0.5 to 2 mg/hour, and the IM dose is 0.5 to 10 mg daily. Dosing of bumetanide and other loop diuretics varies greatly among patients, and doses are carefully adjusted by physicians. Bumetanide may be taken with or without food.
Which drugs or supplements interact with bumetanide?
Bumetanide can cause low blood potassium, calcium, and magnesium levels. These changes can increase the risk of toxicity from digoxin (Lanoxin). Combining bumetanide with other diuretics such as metolazone (Zaroxolyn), hydrochlorothiazide, or chlorthalidone (Hygroton) can exaggerate the losses of potassium and magnesium.
The body's ability to eliminate lithium (Lithobid, Eskalith) may decrease in patients receiving bumetanide. Therefore, careful monitoring of lithium levels in blood is recommended when bumetanide and lithium are taken together in order to prevent increases in lithium levels and lithium toxicity.
Indomethacin (Indocin) can reduce the diuretic and blood pressure-lowering effects of other loop diuretics (for example furosemide) and it probably can do the same with bumetanide. Other nonsteroidal anti-inflammatory drugs, for example, ibuprofen (Motrin), naproxen (Naprosyn) may interact similarly.
Is bumetanide safe to take if I'm pregnant or breastfeeding?
There have been no adequate studies on the effects of bumetanide on the fetus. Thus, the physician must carefully weigh the potential but unknown risks and benefits of bumetanide before prescribing it for pregnant women.
It is not known if bumetanide is excreted into breast milk. Thus, it should be used in women who are breastfeeding only if its potential benefits outweigh the unknown risks.
What else should I know about bumetanide?
What preparations of bumetanide are available?
Tablets: 0.5, 1, and 2 mg. Injection: 0.25 mg/ml
How should I keep bumetanide stored?
Tablets should be stored at room temperature, between 15 C - 30 C (59 F - 86 F).
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Bumetanide, Bumex (discontinued brand) is a "loop diuretic" medication prescribed for the management of edema associated with congestive heart failure, liver and kidney disease, and off-label treatment for high blood pressure. Side effects, dosage, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
Related Disease Conditions
12 Congestive Heart Failure Symptoms, Stages, Causes, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral...
Pulmonary edema (swelling or fluid in the lungs) can either be caused by cardiogenic causes (congestive heart failure, heart...
Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There...
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Treatment & Diagnosis
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Medication Disposal
- Dangers of Mixing Medications
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.