Bullous Pemphigoid: Symptoms & Signs

Medically Reviewed on 5/29/2020

Bullous pemphigoid is an uncommon blistering skin disease characterized by tense blisters on the surface of the skin. Most people affected are 50 years of age or older.

Signs and associated symptoms of bullous pemphigoid include

  • skin blisters,
  • rash,
  • peeling,
  • ulcers, or
  • redness.

Intense itching and burning of the skin is common. Blisters may be found individually, or they may appear in groups. Sometimes, the inner lining tissue of the mouth, nasal passages, or conjunctivae of the eyes (mucous membrane tissue) can be involved.

Cause of bullous pemphigoid

An autoimmune condition in which the immune system makes antibodies that attack a particular layer of the skin or mucous membranes called the basement membrane causes the condition.

Other bullous pemphigoid symptoms and signs


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.