- Crohn's Disease Slideshow
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- What is budesonide (Entocort EC, Uceris)?
- Why is budesonide (Entocort EC, Uceris) prescribed to patients?
- What are the side effects of budesonide (Entocort EC, Uceris)?
- What is the dosage for budesonide (Entocort EC, Uceris)?
- Which drugs or supplements interact with budesonide (Entocort EC, Uceris)?
- Is budesonide (Entocort EC, Uceris) safe to use during pregnancy or while breastfeeding?
- What else should I know about budesonide (Entocort EC, Uceris)?
What is budesonide (Entocort EC, Uceris)?
- Budesonide is a synthetic (man-made) steroid of the glucocorticoid family that is used for treating Crohn's disease.
What brand names are available for budesonide?
- Entocort EC and Uceris are brand names for budesonide in the US.
Why is budesonide (Entocort EC, Uceris) prescribed to patients?
- Budesonide is used for the treatment of mild-to-moderately-active Crohn's disease involving the ileum (the second half of the small intestine) and/or ascending colon (the beginning of the large intestine). It is approved for maintaining remissions for up to three months.
- Budesonide also is used for the induction of remission in patients with active, mild to moderate ulcerative colitis.
- Budesonide rectal foam is used for the induction of remission in patients with active mild to moderate distal ulcerative colitis extending up to 40 cm from the anus.
What are the side effects of budesonide (Entocort EC, Uceris)?
The most common side effects of budesonide are:
- Upper respiratory tract infection
- Abdominal pain
- Back pain
- Flatulence (intestinal gas, farting)
- Abdominal distension
- Urinary tract infections (UTIs)
- Viral infections
- Low potassium
Excessive corticosteroid use causes:
Serious side effects of budesonide include:
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What is the dosage for budesonide (Entocort EC, Uceris)?
- The recommended dose for active Crohn's disease is 9 mg once daily in the morning for up to 8 weeks.
- The 8 week course may be repeated for recurring episodes.
- The dose for maintenance of remission is 6 mg once daily for 3 months.
- The recommended dosage for the induction of remission in adult patients with active, mild to moderate ulcerative colitis is one 9 mg extended release tablet to be taken once daily in the morning for up to 8 weeks.
- The recommended dose for the spray is 1 spray administered twice daily for 2 weeks followed by 1 spray once daily for 4 weeks.
Which drugs or supplements interact with budesonide (Entocort EC, Uceris)?
Medicines which block the liver enzymes that break down budesonide may lead to higher blood concentrations and more side effects of budesonide. Such medications include
- ketoconazole (Nizoral),
- fluconazole (Diflucan),
- itraconazole (Sporanox),
- clarithromycin (Biaxin),
- verapamil (for example, Calan; Isoptin; Covera HS),
- diltiazem (for example, Cardizem; Dilacor),
- ritonavir (Norvir; Kaletra),
- indinavir (Crixivan), and
- saquinavir (Invirase, Fortovase).
Grapefruit juice has a similar effect and should not be consumed by patients taking budesonide.
Is budesonide (Entocort EC, Uceris) safe to use during pregnancy or while breastfeeding?
- There are no adequate studies in pregnant women. Budesonide should only be used in pregnant women if the benefits outweigh the unknown risk. Use of budesonide during pregnancy may suppress the adrenal glands of the infant.
- Budesonide is secreted in human breast milk. Because of the potential for adverse reactions in nursing infants from any corticosteroid, a decision should be made whether to discontinue nursing or discontinue the budesonide.
What else should I know about budesonide (Entocort EC, Uceris)?
What preparations of budesonide (Entocort EC, Uceris) are available?
- Capsules: 3 mg
- Tablets (Extended Release): 9 mg
- Rectal foam: 2 mg per spray
How should I keep budesonide (Entocort EC, Uceris) stored?
- Capsules should be stored between 15 C and 30 C (59 F and 86 F)
How does budesonide (Entocort EC, Uceris) work?
- The naturally-occurring hormone whose actions budesonide mimics, is cortisol or hydrocortisone which is produced by the adrenal glands. Glucocorticoid steroids have potent anti-inflammatory actions. Crohn's disease is a chronic inflammatory bowel disease of unknown cause that results in diarrhea, crampy abdominal pain, fever and bleeding from the rectum. The active ingredient in Budesonide, is released from granules in the ileum of the small intestine and the right (proximal) colon, where the inflammation of Crohn's disease occurs. Budesonide acts directly by contact with the ileum and colon. Budesonide that is absorbed into the body travels first to the liver where it is broken-down and eliminated from the body. This prevents the majority of the absorbed drug from being distributed to the rest of the body. As a result, budesonide causes fewer severe side effects throughout the body than other corticosteroids.
When was budesonide (Entocort EC, Uceris) approved by the FDA?
- The FDA approved budesonide in October of 2001.
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Budesonide (Entocort EC, Uceris) is a medication prescribed for the treatment of mild-to-moderately active Crohn's disease. Side effects include back pain, dizziness, fatigue, indigestion, vomiting, intestinal gas, arthritis, or constipation. Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety should be reviewed prior to taking this medication.
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Related Disease Conditions
Asthma is a condition in which hyperreactive airways constrict and result in symptoms like wheezing, coughing, and shortness of breath. Causes of asthma include genetics, environmental factors, personal history of allergies, and other factors. Asthma is diagnosed by a physician based on a patient's family history and results from lung function tests and other exams. Inhaled corticosteroids (ICS) and long-acting bronchodilators (LABAs) are used in the treatment of asthma. Generally, the prognosis for a patient with asthma is good. Exposure to allergens found on farms may protect against asthma symptoms.
Crohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect other parts of the digestive system as well. Abdominal pain, diarrhea, vomiting, fever, and weight loss are common symptoms.
Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)
Microscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps.
COPD (Chronic Obstructive Pulmonary Disease)
COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. Conditions that accompany COPD include chronic bronchitis, chronic cough, and emphysema. Symptoms of COPD include shortness of breath, wheezing, and chronic cough. Treatment of COPD includes GOLD guidelines, smoking cessation, medications, and surgery. The life expectancy of a person with COPD depends on the stage of the disease.
Chronic Rhinitis and Post-Nasal Drip
Chronic rhinitis and post-nasal drip symptoms include an itchy, runny nose, sneezing, itchy ears, eyes, and throat. Seasonal allergic rhinitis (also called hay fever) usually is caused by pollen in the air. Perennial allergic rhinitis is a type of chronic rhinitis and is a year-round problem, often caused by indoor allergens, such as dust, animal dander, and pollens that may exist at the time. Treatment of chronic rhinitis and post nasal drip are dependent upon the type of rhinitis condition.
Inflammatory Bowel Disease (Intestinal Problems of IBD)
The inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
Primary Biliary Cirrhosis Treatment (PBC)
Primary biliary sclerosis (PBC) is thought to be an autoimmune disorder that involves the deterioration of the liver's small bile ducts. These ducts are crucial to transport bile to the small intestine, digesting fats and removing wastes. Symptoms of PBC are: Edema Itching Elevated cholesterol Malabsorption of fat Liver cancer Gallstones Urinary tract infections (UTIs) Hypothyroidism Treatments include ursodeoxycholic acid (UDCA); colchicine (Colcrys); and immunosuppressive medications, such as corticosteroids; obeticholic acid (Ocaliva); and medications that treat PBC symptoms. For PBC that is associated with cirrhosis of the liver, liver transplantation may be indicated in extreme cases.
Colitis refers to inflammation of the inner lining of the colon. Symptoms of the inflammation of the colon lining include diarrhea, pain, and blood in the stool. There are several causes of colitis, including infection, ischemia of the colon, inflammatory bowel disease (Crohn's disease, ulcerative colitis, infectious colitis like C. difficile, or microscopic colitis). Treatment depends on the cause of the colitis.
Ulcerative Colitis Diet Plan
An ulcerative colitis diet plan can help a person with the disease avoid foods and drinks that trigger flares. There also are foods that can soothe ulcerative colitis symptoms during a flare. Types of ulcerative colitis plans include a high-calorie diet, a lactose-free diet, a low-fat diet, a low-fiber diet (low-residue diet), or a low-salt diet. Self-management of ulcerative colitis using healthy lifestyle habits and a nutrient rich diet can be effective in management of the disease. Learn what foods to avoid that aggravate, and what foods help symptoms of the disease and increase bowel inflammation.
Is Colitis Contagious?
Colitis is a term that us used to describe inflammation of the colon. The terms enteritis, proctitis, and inflammatory bowel disease (IBD) now include colitis. Colitis has many different causes. Some types of colitis are contagious and some are not contagious. Symptoms of colitis include diarrhea, abdominal discomfort, cramping, pain, and blood in the stools. Treatment for colitis depends on the cause and type of colitis.
Crohn's Disease vs. Ulcerative Colitis (UC)
Crohn's disease and ulcerative colitis are diseases that cause inflammation of part of or the entire digestive tract (GI). Crohn's affects the entire GI tract (from the mouth to the anus), while ulcerative colitis or ulcerative colitis only affects the large and small intestine and ilium. Researchers do not know the exact cause of either disease. About 20% of people with Crohn's disease also have a family member with the disease. Researchers believe that certain factors may play a role in causing UC. Both Crohn's disease and ulcerative colitis are a type of inflammatory bowel disease, or IBD. Crohn's disease and ulcerative colitis both have similar symptoms and signs, for example, nausea, loss of appetite, fatigue, weight loss, episodic and/or persistent diarrhea, fever, abdominal pain and cramping, rectal bleeding, bloody stools, joint pain and soreness, eye redness, or pain. Symptoms unique to Crohn’s disease include anemia and skin changes. Symptoms of unique to ulcerative colitis include, certain rashes, an urgency to defecate (have a bowel movement). Doctors diagnose both diseases with similar tests and procedures. While there is no cure for either disease, doctors and other health care professionals can help you treat disease flares, and manage your Crohn's or ulcerative colitis with medication, diet, nutritional supplements, and/or surgery.
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