- What is brimonidine, and how does it work (mechanism of action)?
- What brand names are available for brimonidine?
- Is brimonidine available as a generic drug?
- Do I need a prescription for brimonidine?
- What are the side effects of brimonidine?
- What is the dosage for brimonidine?
- Is brimonidine safe to take if I'm pregnant or breastfeeding?
- What else should I know about brimonidine?
What is brimonidine, and how does it work (mechanism of action)?
Brimonidine is is an ophthalmic solution used for the treatment of one type of glaucoma, open-angle glaucoma. In this type of glaucoma, too much fluid (aqueous humor) is made within the eye and causes high pressures within the eye. The pressure damages the nerves in the eye responsible for vision, and this ultimately causes blindness. Brimonidine reduces the body's production of aqueous humor and increases the flow of aqueous humor out of the eye, resulting in a decrease in pressure. It accomplishes this by stimulating alpha type 2 receptors selectively in the eye with less effect on alpha type 2 receptors elsewhere in the body. It is the first drug of its class to be used for glaucoma. Brimonidine was approved by the FDA in 1996.
What are the side effects of brimonidine?
Common side effects include:
- dry eyes,
- red eyes,
- irritation of the eyes,
- blurred vision,
- a sensation of a foreign body in the eye, and
Other important side effects of brimonidine include:
Is brimonidine safe to take if I'm pregnant or breastfeeding?
It is not known if brimonidine is secreted in breast milk.
What else should I know about brimonidine?
What preparations of brimonidine are available?
Ophthalmic solution: 0.1%, 0.15%, and 0.2%.
How should I keep brimonidine stored?
Brimonidine should be kept at room temperature, 15 C to 30 C (59 F to 86 F) and protected for direct light.
Reference: FDA Prescribing Information
Brimonidine (Alphagan, Alphagan P - Discontinued in the US) is a drug prescribed for the treatment of open-angle glaucoma. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
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GlaucomaGlaucoma is a common eye condition in which the fluid pressure inside the eye rises because of slowed fluid drainage from the eye. If untreated, glaucoma may damage the optic nerve and other parts of the eye, causing the loss of vision or even blindness.