- What other names is Bridelia known by?
- What is Bridelia?
- How does Bridelia work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Bridelia.
Asas, Assas, Bridelia cathartica, Bridelia ferruginea, Bridelia grandis, Bridelia micrantha, Bridelia monoica, Bridelia retusa, Bridelia stipularis, Mist Bredina.
Bridelia is the name for a plant genus. The leaf, stem bark, and root are used to make medicine.
People take Bridelia leaf, stem bark, or root by mouth to prevent pregnancy, to cause labor, for malaria, AIDS/HIV, anemia, asthma, cancer, colic, cough, diabetes, diarrhea, enlarged spleen, gonorrhea, hernia, joint pain, menstruation that is abnormal or painful, stomachaches and other stomach problems, syphilis, thrush, to kill parasites, urinary tract infections, yellow fever, yellow skin discoloration (jaundice), as an insecticide, and as a strong laxative.
Insufficient Evidence to Rate Effectiveness for...
- To prevent pregnancy.
- To cause labor.
- Enlarged spleen.
- Joint pain.
- Menstruation that is abnormal or painful.
- Skin wounds.
- Stomach aches and other stomach problems.
- To kill parasites.
- Urinary tract infections.
- Yellow fever.
- Yellow skin discoloration (jaundice).
- Other conditions.
Bridelia might reduce swelling, lessen pain, and lower fevers. Bridelia might also prevent the growth of organisms that cause infections. Bridelia might have similar effects as the female hormone estrogen. It might also have antioxidant effects.
It isn't known if Bridelia is safe. There is concern that Bridelia might lower blood pressure and heart rate.
Special Precautions & Warnings:Pregnancy and breast-feeding: Bridelia is LIKELY UNSAFE when used during pregnancy. There is concern that Bridelia might stimulate the uterus and cause labor. Avoid using.
Not enough is known about the use of Bridelia during breast-feeding. Stay on the safe side and avoid use.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Bridelia might have the same effects as the female hormone estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Bridelia.
Surgery: Bridelia might slow blood clotting. In theory, Bridelia might cause extra bleeding or affect blood pressure control during and after surgery. Stop using it at least 2 weeks before a scheduled surgery.
EstrogensInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Bridelia might have some of the same effects as estrogen. However, Bridelia is not as strong as estrogen pills. Taking Bridelia along with estrogen pills might decrease the effects of estrogen pills.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Bridelia might lower blood pressure. Taking Bridelia along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Bridelia might slow blood clotting. Taking Bridelia along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
The appropriate dose of Bridelia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Bridelia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
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Ajaiyeoba EO, Abiodun OO, Falade MO, et al. In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine 2006;13(4):295-8. View abstract.
Akinpelu DA, Olorunmola FO. Antimicrobial activity of Bridelia ferruginea fruit. Fitoterapia 2000;71(1):75-6. View abstract.
Cimanga K, De Bruyne T, Apers S, et al. Complement-Inhibiting constituents of Bridelia ferruginea stem bark. Planta Med 1999;65(3):213-7. View abstract.
Cimanga K, Ying L, De Bruyne T, et al. Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark. J Pharm Pharmacol 2001;53(5):757-61. View abstract.
Corallo A, Foungbe S, Davy M, Cohen Y. Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat. J Ethnopharmacol 1997;57(3):189-96. View abstract.
Corallo A, Savineau JP, Tricoche R, Foungbe S. The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat. Fundam Clin Pharmacol 1991;5(4):319-29. View abstract.
Gangoue-Pieboji J, Baurin S, Frere JM, et al. Screening of some medicinal plants from cameroon for beta-lactamase inhibitory activity. Phytother Res 2007;21(3):284-7. View abstract.
Irobi ON, Moo-Young M, Anderson WA, Daramola SO. Antimicrobial activity of bark extracts of Bridelia ferruginea (Euphorbiaceae). J Ethnopharmacol 1994;43(3):185-90. View abstract.
Jayasinghe L, Kumarihamy BM, Jayarathna KH, et al. Antifungal constituents of the stem bark of Bridelia retusa. Phytochemistry 2003;62(4):637-41. View abstract.
Jurg A, Tomas T, Pividal J. Antimalarial activity of some plant remedies in use in Marracuene, southern Mozambique. J Ethnopharmacol 1991;33(1-2):79-83. View abstract.
Lin J, Puckree T, Mvelase TP. Anti-diarrhoeal evaluation of some medicinal plants used by Zulu traditional healers. J Ethnopharmacol 2002;79(1):53-6. View abstract.
Malkani NP. "Plants of Dehli: scientific names and their meaning." Plant Taxonomy: past, present, and future. Ed. Gupta R. New Delhi: The Energy and Resource Institute (TERI), 2011.
Mostafa M, Nahar N, Mosihuzzaman M, et al. Phosphodiesterase-I inhibitor quinovic acid glycosides from Bridelia ndellensis. Nat Prod Res 2006;20(7):686-92. View abstract.
Ngueyem TA, Brusotti G, Caccialanza G, Finzi PV. The genus Bridelia: a phytochemical and ethnopharmacological review. J Ethnopharmacol 2009;124(3):339-49. View abstract.
Ngueyem TA, Brusotti G, Marrubini G, et al. Validation of use of a traditional remedy from Bridelia grandis (Pierre ex Hutch) stem bark against oral Streptococci. J Ethnopharmacol 2008;120(1):13-6. View abstract.
Njamen D, Magne Nde CB, Tanee Fomum Z, Vollmer G. Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats. Pharmazie 2008;63(2):164-8. View abstract.
Olajide OA, Makinde JM, Awe SO. Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. J Ethnopharmacol 1999;66(1):113-7. View abstract.
Olajide OA, Makinde JM, Okpako DT, Awe SO. Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. J Ethnopharmacol 2000;71(1-2):153-60. View abstract.
Olajide OA, Okpako DT, Makinde JM. Anti-inflammatory properties of Bridelia ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. J Ethnopharmacol 2003;88(2-3):221-4. View abstract.
Olajide, O. A. Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 1999;13(3):231-232. View abstract.
Omolo OJ, Chhabra SC, Nyagah G. Determination of iron content in different parts of herbs used traditionally for anaemia treatment in East Africa. J Ethnopharmacol 1997;58(2):97-102. View abstract.
Omolo OJ, Chhabra SC, Nyagah G. Iron content of some edible leafy vegetables and medicinal plants used traditionally for anaemia treatment in East Africa. Afr J Health Sci 2001;8(1-2):55-60. View abstract.
Onoruvwe O, Olayinka AO, Lot TY, Udoh FV. Effects of stem bark and leaf extracts of Bridelia ferruginea on rat bladder smooth muscle. Fitoterapia 2001;72(3):230-5. View abstract.
Ramesh N, Viswanathan MB, Saraswathy A, et al. Antibacterial activity of luteoforol from Bridelia crenulata. Fitoterapia 2001;72(4):409-11. View abstract.
Sueyoshi E, Liu H, Matsunami K, et al. Bridelionosides A-F: Megastigmane glucosides from Bridelia glauca f. balansae. Phytochemistry 2006;67(22):2483-93. View abstract.
Talla E, Djamen D, Djoulde D, et al. Antimicrobial activity of Bridelia ferruginea leaves extracts. Fitoterapia 2002;73(4):343-5. View abstract.
Theophile D, Laure NE, Benoit NT, et al. Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae). Inflammopharmacology 2006;14(1-2):42-7. View abstract.