Boneset

What other names is Boneset known by?

Agueweed, Bois Perfolié, Crosswort, Eupatoire, Eupatoire Perfoliée, Eupatorio, Eupatorium perfoliatum, Feverwort, Herbe à Fièvre, Herbe à Souder, Indian Sage, Sweating Plant, Teasel, Thoroughwort, Vegetable Antimony.

What is Boneset?

Boneset is a plant. People use the dried leaf and flowers to make medicine.

Boneset is used to reduce fever, increase urine output, cause vomiting, and treat constipation.

Boneset is also used to treat influenza, swine flu, acute bronchitis, nasal inflammation, joint pain (rheumatism), fluid retention, dengue fever, and pneumonia; as a stimulant; and to cause sweating.

Insufficient Evidence to Rate Effectiveness for...

  • Common cold. Early research suggests that taking a specific homeopathic product made from boneset (Eupatorium perfoliatum D2) reduces symptoms of the common cold similarly to aspirin.
  • Constipation.
  • Causing vomiting.
  • Fluid retention.
  • Aching muscles.
  • Reducing inflammation.
  • Stimulating the immune system.
  • Other conditions.
More evidence is needed to rate the effectiveness of boneset for these uses.

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How does Boneset work?

Boneset contains chemicals that might work like anti-cancer medications. It also might have some mild activity against bacteria.

Are there safety concerns?

Boneset is POSSIBLY UNSAFE when taken by mouth in large amounts. Some plants that are related to boneset contain chemicals called pyrrolizidine alkaloids that can damage the liver. It is not known if boneset contains these chemicals.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Because boneset may contain liver-damaging chemicals called pyrrolizidine alkaloids, it is considered POSSIBLY UNSAFE. Don't use it if you are pregnant or breast-feeding.

Allergy to ragweed and related plants: Boneset may cause an allergic reaction in people who are sensitive to plants in the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking boneset.

Liver disease: Boneset contains chemicals called hepatotoxic pyrrolizidine alkaloids (PAs). These chemicals might harm the liver, making existing liver disease worse.

Are there any interactions with medications?


Medications that increase the breakdown of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Boneset is broken down by the liver. Some chemicals that form when the liver breaks down boneset can be harmful. Medications that cause the liver to break down boneset might enhance the toxic effects of chemicals contained in boneset.

Some of the medications include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Dosing considerations for Boneset.

The appropriate dose of boneset depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for boneset. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019
References

Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736. View abstract.

Herz, W., Kalyanaraman, P. S., and Ramakrishnan, G. Sesquiterpene lactones of Eupatorium perfoliatum. J Org.Chem 6-24-1977;42(13):2264-2271. View abstract.

Wagner, H. and Jurcic, K. [Immunologic studies of plant combination preparations. In-vitro and in-vivo studies on the stimulation of phagocytosis]. Arzneimittelforschung. 1991;41(10):1072-1076. View abstract.

Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. View abstract.

Habtemariam S, Macpherson AM. Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum). Phytother Res 2000;14:575-7. . View abstract.

Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. View abstract.