- What other names is Bitter Almond known by?
- What is Bitter Almond?
- How does Bitter Almond work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Bitter Almond.
Almendra Amarga, Almendro Amargo, Amande Amère, Amandier Amer, Amandier à Fruits Amers, Amendoa Amarga, Amygdala Amara, Amygdalus communis var. amara, Amygdalus dulcis var. amara, Bitter Almond Oil, Bitter Almond Tree, Bittere Amandel, Bittere Mandel, Bittere Mandeln, Bittere-Amandelboom, Bittermandel, Bittermandelbaum, Bittermandeltræ, Bittermandeltraed, Huile d'Amande Volatile, Huile d'Amande Amère, Karvasmanteli, Mandorla Amara, Mandorlo Amaro, Mindal' Gor'kii, Prunus amygdalus var. amara, Prunus communis var. amara, Prunus dulcis var. amara, Volatile Almond Oil.
Almonds are a familiar type of nut. They can be sweet or bitter, depending on the type of tree that produces them. Sweet almond is produced from one type of almond tree (Prunus amygdalus var. dulcis) and does not contain poisonous chemicals. Bitter almond comes from a different type of almond tree (Prunus amygdalus var. amara) and does contain toxic chemicals.
“Bitter almond” volatile oils can also be produced from other related fruit kernels including apricot (Prunus armeniaca), peach (Prunus persica), and plum (Prunus domestica). Similar to bitter almond, these volatile oils are considered poisonous.
Insufficient Evidence to Rate Effectiveness for...
There is not enough scientific information available to know how bitter almond might work for any medical condition. Bitter almond contains a poisonous chemical called hydrocyanic acid (HCN), which can cause serious side effects.
Do not use bitter almond. Bitter almond is considered LIKELY UNSAFE when taken by mouth. It contains a poisonous chemical called hydrocyanic acid (HCN). Serious side effects can occur such as slowing of the nervous system, breathing problems, and death.
Special Precautions & Warnings:It is LIKELY UNSAFE for anyone to use bitter almond, but some people have extra reasons not to use it:
Surgery: Bitter almond can slow down the nervous system. Anesthesia and other drugs used during surgery do this as well. Using bitter almond along with these medications can slow down the central nervous system too much. Stop using bitter almond at least 2 weeks before a scheduled surgery.
Sedative medications (CNS depressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Bitter almond can be toxic and might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking bitter almond along with sedative medications might cause too much sleepiness.
The appropriate dose of bitter almond depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bitter almond. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Ames, M. M., Kovach, J. S., and Flora, K. P. Initial pharmacologic studies of amygdalin (laetrile) in man. Res Commun.Chem Pathol.Pharmacol. 1978;22(1):175-185. View abstract.
Anonymous. Report by the cancer commission of the California Medical Association: the treatment of cancer with "laetriles". California Med 1953;78(4):320-326.
Anonymous. Toxicity of Laertile. FDA Drug Bull 1977;7:26-32.
Araya, E., Rodriguez, A., Rubio, J., Spada, A., Joglar, J., Llebaria, A., Lagunas, C., Fernandez, A. G., Spisani, S., and Perez, J. J. Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T. Bioorg.Med Chem Lett. 3-1-2005;15(5):1493-1496. View abstract.
Baroni, A., Paoletti, I., Greco, R., Satriano, R. A., Ruocco, E., Tufano, M. A., and Perez, J. J. Immunomodulatory effects of a set of amygdalin analogues on human keratinocyte cells. Exp Dermatol 2005;14(11):854-859. View abstract.
Beamer, W. C., Shealy, R. M., and Prough, D. S. Acute cyanide poisoning from laetrile ingestion. Ann.Emerg.Med 1983;12(7):449-451. View abstract.
Bhatti RA, Ablin RJ, and Guinan PD. Tumour-associated directed immunity in prostatic cancer: effect of amygdalin. IRCS Med Sci 1981;9(1):19.
Biaglow, J. E. and Durand, R. E. The enhanced radiation response of an in vitro tumour model by cyanide released from hydrolysed amygdalin. Int J Radiat Biol Relat Stud.Phys Chem Med 1978;33(4):397-401. View abstract.
Braico, K. T., Humbert, J. R., Terplan, K. L., and Lehotay, J. M. Laetrile intoxication. Report of a fatal case. N.Engl.J Med 2-1-1979;300(5):238-240. View abstract.
Brown WE, Wood CD, and Smith AN. Sodium cyanide as a cancer chemotherapeutic agent: laboratory and clinical studies. Amer J Obstet Gyn 1960;80(5):907-918.
Chan, T. Y. A probable case of amygdalin-induced peripheral neuropathy in a vegetarian with vitamin B12 deficiency. Ther Drug Monit. 2006;28(1):140-141. View abstract.
Chang, H. K., Shin, M. S., Yang, H. Y., Lee, J. W., Kim, Y. S., Lee, M. H., Kim, J., Kim, K. H., and Kim, C. J. Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. Biol Pharm Bull. 2006;29(8):1597-1602. View abstract.
Gill, J. R., Marker, E., and Stajic, M. Suicide by cyanide: 17 deaths. J Forensic Sci 2004;49(4):826-828. View abstract.
Gostomski FE. The effects of amygdalin on the Krebs-2 carcinoma in adult and fetal DUB (ICR) mice. Disseration Abstracts International 1978;39(5):2075-B.
Hill, G. J., Shine, T. E., Hill, H. Z., and Miller, C. Failure of amygdalin to arrest B16 melanoma and BW5147 AKR leukemia. Cancer Res 1976;36(6):2102-2107. View abstract.
Humbert, J. R., Tress, J. H., and Braico, K. T. Fatal cyanide poisoning: accidental ingestion of amygdalin. JAMA 8-8-1977;238(6):482. View abstract.
Khandekar, J. D. and Edelman, H. Studies of amygdalin (laetrile) toxicity in rodents. JAMA 7-13-1979;242(2):169-171. View abstract.
Laster, W. R., Jr. and Schabel, F. M., Jr. Experimental studies of the antitumor activity of amygdalin MF (NSC- 15780) alone and in combination with beta-glucosidase (NSC-128056). Cancer Chemother Rep 1975;59(5):951-965. View abstract.
Lea, M. A. and Koch, M. R. Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat. J Natl.Cancer Inst. 1979;63(5):1279-1283. View abstract.
Liegner, K. B., Beck, E. M., and Rosenberg, A. Laetrile-induced agranulocytosis. JAMA 12-18-1981;246(24):2841-2842. View abstract.
Manner HW, DiSanti SJ, Maggio MI, and et al. Amygdalin, vitamin A and enzyme induced regression of murine mammary adenocarcinomas. J Manip Physiol Ther 1978;1(4):246-248.
Messiha, F. S. Effect of almond and anis oils on mouse liver alcohol dehydrogenase, aldehyde dehydrogenase and heart lactate dehydrogenase isoenzymes. Toxicol.Lett. 1990;54(2-3):183-188. View abstract.
Milazzo, S., Ernst, E., Lejeune, S., and Schmidt, K. Laetrile treatment for cancer. Cochrane.Database.Syst.Rev 2006;(2):CD005476. View abstract.
Moertel, C. G., Ames, M. M., Kovach, J. S., Moyer, T. P., Rubin, J. R., and Tinker, J. H. A pharmacologic and toxicological study of amygdalin. JAMA 2-13-1981;245(6):591-594. View abstract.
Moertel, C. G., Fleming, T. R., Rubin, J., Kvols, L. K., Sarna, G., Koch, R., Currie, V. E., Young, C. W., Jones, S. E., and Davignon, J. P. A clinical trial of amygdalin (Laetrile) in the treatment of human cancer. N.Engl.J.Med. 1-28-1982;306(4):201-206. View abstract.
Morrone JA. Chemotherapy of inoperable cancer: preliminary report of 10 cases treated with laetrile. J Exper Med Surg 1962;20:299-308.
Moss, M., Khalil, N., and Gray, J. Deliberate self-poisoning with Laetrile. Can.Med Assoc J 11-15-1981;125(10):1126, 1128. View abstract.
Navarro MD. Five years experience with laetrile therapy in advanced cancer. Acta Unio Internat Contra Cancrum 1959;15(suppl 1):209-221.
Navarro MD. The Philippine experience in the early detection and chemotherapy of cancer. Santo Tomas J Med 1970;25(3):125-133.
O'Brien, B., Quigg, C., and Leong, T. Severe cyanide toxicity from 'vitamin supplements'. Eur J Emerg.Med 2005;12(5):257-258. View abstract.
Ortega, J. A. and Creek, J. E. Acute cyanide poisoning following administration of Laetrile enemas. J Pediatr. 1978;93(6):1059. View abstract.
Ovejera, A. A., Houchens, D. P., Barker, A. D., and Venditti, J. M. Inactivity of DL-amygdalin against human breast and colon tumor xenografts in athymic (nude) mice. Cancer Treat.Rep 1978;62(4):576-578. View abstract.
Pack, W. K., Raudonat, H. W., and Schmidt, K. [Lethal poisoning with hydrocyanic acid after ingestion of bitter almonds (Prunus amygdalus)]. Z.Rechtsmed. 1972;70(1):53-54. View abstract.
Park, H. J., Yoon, S. H., Han, L. S., Zheng, L. T., Jung, K. H., Uhm, Y. K., Lee, J. H., Jeong, J. S., Joo, W. S., Yim, S. V., Chung, J. H., and Hong, S. P. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol 9-7-2005;11(33):5156-5161. View abstract.
Rauws, A. G., Olling, M., and Timmerman, A. The pharmacokinetics of prunasin, a metabolite of amygdalin. J Toxicol.Clin Toxicol. 1982;19(8):851-856. View abstract.
Ross, W. E. Unconventional cancer therapy. Compr.Ther 1985;11(9):37-43. View abstract.
Sadoff, L., Fuchs, K., and Hollander, J. Rapid death associated with laetrile ingestion. JAMA 4-14-1978;239(15):1532. View abstract.
Shragg, T. A., Albertson, T. E., and Fisher, C. J., Jr. Cyanide poisoning after bitter almond ingestion. West J Med 1982;136(1):65-69. View abstract.
Smith, F. P., Butler, T. P., Cohan, S., and Schein, P. S. Laetrile toxicity: a report of two patients. Cancer Treat.Rep 1978;62(1):169-171. View abstract.
Soranzo, N., Bufe, B., Sabeti, P. C., Wilson, J. F., Weale, M. E., Marguerie, R., Meyerhof, W., and Goldstein, D. B. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol 7-26-2005;15(14):1257-1265. View abstract.
Stock, C. C., Tarnowski, G. S., Schmid, F. A., Hutchison, D. J., and Teller, M. N. Antitumor tests of amygdalin in transplantable animal tumor systems. J Surg Oncol 1978;10(2):81-88. View abstract.
Syrigos, K. N., Rowlinson-Busza, G., and Epenetos, A. A. In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody. Int J Cancer 12-9-1998;78(6):712-719. View abstract.
Vickers, A. J., Kuo, J., and Cassileth, B. R. Unconventional anticancer agents: a systematic review of clinical trials. J Clin Oncol 1-1-2006;24(1):136-140. View abstract.
Wodinsky, I. and Swiniarski, J. K. Antitumor activity of amygdalin MF (NSC-15780) as a single agent and with beta-glucosidase (NSC-128056) on a spectrum of transplantable rodent tumors. Cancer Chemother Rep 1975;59(5):939-950. View abstract.
Zhu, Y. P., Su, Z. W., and Li, C. H. [Analgesic effect and no physical dependence of amygdalin]. Zhongguo Zhong.Yao Za Zhi. 1994;19(2):105-107, 128. View abstract.