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- What is bisoprolol, and how does it work (mechanism of action)?
- What brand names are available for bisoprolol?
- Is bisoprolol available as a generic drug?
- Do I need a prescription for bisoprolol?
- What are the side effects of bisoprolol?
- What is the dosage for bisoprolol?
- Which drugs or supplements interact with bisoprolol?
- Is bisoprolol safe to take if I'm pregnant or breastfeeding?
- What else should I know about bisoprolol?
What is bisoprolol, and how does it work (mechanism of action)?
Bisoprolol belongs to a class of drugs called beta-adrenergic receptor blocking agents that also includes propranolol (Inderal), atenolol (Tenormin), and timolol (Blocadren). Bisoprolol is used for treating high blood pressure and heart pain (angina). Bisoprolol prevents the neurotransmitters (chemicals that nerves use to communicate with other nerves), norepinephrine and epinephrine (adrenaline), from binding to beta receptors on nerves. By blocking the effect of norepinephrine and epinephrine on the nerves reaching the heart and blood vessels, beta blockers reduce heart rate and the force with which the heart contracts and reduce blood pressure by dilating blood vessels but may constrict air passages by stimulating the muscles that surround the air passages. Angina occurs when the heart's need for oxygen exceeds the supply of oxygen-carrying blood. By slowing heart rate and decreasing the force with which the heart muscle contracts, bisoprolol reduces the work of the heart and the demand of the heart for oxygen. The FDA approved bisoprolol in July 1992.
What are the side effects of bisoprolol?
Bisoprolol is generally well-tolerated, and side effects are mild and transient. Side effects include:
- abdominal cramps,
- slow heart rate,
- low blood pressure,
- cold extremities,
- sore throat, and
- shortness of breath or
Patients with asthma may have symptoms increase.
What is the dosage for bisoprolol?
Which drugs or supplements interact with bisoprolol?
: Rifampin may increase the metabolism (destruction) of bisoprolol, possibly making bisoprolol less effective. Certain calcium channel blockers (CCBs), especially verapamil (Calan, Isoptin) and diltiazem (Cardizem, Tiazac), may enhance the effect of bisoprolol on the heart. In some patients, this may cause excessive slowing of the heart rate or reduce the heart's ability to beat. The use of digoxin (Lanoxin) with bisoprolol also may cause an excessive reduction in heart rate.
Is bisoprolol safe to take if I'm pregnant or breastfeeding?
It is not known if bisoprolol is secreted in breast milk.
What else should I know about bisoprolol?
What preparations of bisoprolol are available?
Tablets: 5 and 10 mg.
How should I keep bisoprolol stored?
Bisoprolol should be stored at room temperature, 15 C to 30 C (59 F to 86 F) in an air-tight container.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
bisoprolol (Zebeta) is a medication in the class of drugs called beta blockers. Bisoprolol (Zebeta) is prescribed for the treatment of high blood pressure, angina, and congestive heart failure. Side effects, warnings and precautions, drug interactions, and patient information should be reviewed prior to taking any medication.
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Medications & Supplements
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- metoprolol (Lopressor, Toprol XL)
- Drug Interactions
- Beta Blocker Side Effects (Adverse Effects)
- atenolol, Tenormin
- propranolol, Inderal, Inderal LA, Innopran XL
- Sectral (acebutolol)
- nadolol (Corgard)
- timolol ophthalmic solution (Timoptic, Timoptic-XE, Timoptic in Ocudose)
- bisoprolol and hydrochlorothiazide, Ziac
- timolol (Blocadren and Timolide 10-25 have been discontinued)
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.