- What other names is Biotin known by?
- What is Biotin?
- Is Biotin effective?
- How does Biotin work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Biotin.
Biotin is used for preventing and treating biotin deficiency associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. It is also used orally for hair loss, brittle nails, skin rash in infants (seborrheic dermatitis), diabetes, and mild depression.
supplements is not usually necessary.
There is some scientific evidence that it might help for brittle finger and toenails.
There isn't enough information to know if biotin is effective for the other conditions people use it for, including: malnutrition, hair loss, diabetes, and others.
Likely Effective for...
- Treating and preventing biotin deficiency. Symptoms of deficiency include thinning of the hair (often with loss of hair color), and red scaly rash around the eyes, nose, and mouth. Other symptoms include depression, listlessness, hallucinations, and tingling in the arms and legs. There is some evidence that cigarette smoking may cause mild biotin deficiency.
Possibly Ineffective for...
- Skin rash in infants (seborrheic dermatitis).
Insufficient Evidence to Rate Effectiveness for...
- Hair loss. There is some preliminary evidence that hair loss can be reduced when biotin is taken by mouth in combination with zinc while a cream containing the chemical compound clobetasol propionate (Olux, Temovate) is applied to the skin.
- Diabetes. Biotin alone doesn't seem to affect blood sugar levels in people with type 2 diabetes. However, there is some evidence that a combination of biotin and chromium (Diachrome, Nutrition 21) might lower blood sugar in people with diabetes, whose diabetes is poorly controlled by prescription medicines. Other early evidence shows that the same combination reduces ratios of total cholesterol levels to "good" high-density lipoprotein (HDL) cholesterol, "bad" low-density lipoprotein (LDL) cholesterol to HDL cholesterol, and non-HDL to HDL cholesterol in people with type 2 diabetes.
- Diabetic nerve pain. There is some evidence that biotin can reduce nerve pain in people with diabetes.
- Brittle fingernails and toenails. Biotin might increase the thickness of fingernails and toenails in people with brittle nails.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Quick GuideVitamin D Deficiency: How Much Vitamin D Is Enough?
There isn't a good laboratory test for detecting biotin deficiency, so this condition is usually identified by its symptoms, which include thinning of the hair (frequently with loss of hair color) and red scaly rash around the eyes, nose, and mouth. Nervous system symptoms include depression, exhaustion, hallucinations, and tingling of the arms and legs. There is some evidence that diabetes could result in biotin deficiency.
Special Precautions & Warnings:Pregnancy and breast-feeding: Biotin is POSSIBLY SAFE when used in recommended amounts during pregnancy and breast-feeding.
Kidney dialysis: People receiving kidney dialysis may need extra biotin. Check with your health care provider.
Medications changed by the liver (Cytochrome P450 1B1 (CYP1B1) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.
Some medications are changed and broken down by the liver. Biotin might decrease how quickly the liver breaks down some medications. Taking biotin along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking biotin, talk to your healthcare provider if you take any medications that are changed by the liver.
Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
There is no recommended dietary allowance (RDA) established for biotin. The adequate intakes (AI) for biotin are 7 mcg for infants 0-12 months, 8 mcg for children 1-3 years, 12 mcg for children 4-8 years, 20 mcg for children 9-13 years, 25 mcg for adolescents 14-18 years, 30 mcg for adults over 18 years and pregnant women, and 35 mcg for breast-feeding women.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Last Editorial Review: 3/29/2011