Generic drug: phenylephrine hydrochloride
Brand name: Biorphen
What is Biorphen (phenylephrine hydrochloride), and how does it work?
Biorphen (phenylephrine hydrochloride) is an alpha-1 adrenergic receptor agonist used to treat clinically important low blood pressure (hypotension) resulting primarily from vasodilation in the setting of anesthesia.
What are the side effects of Biorphen?
Side effects of Biorphen include:
What is the dosage for Biorphen?
General Dosage And Administration Instructions
During Biorphen administration:
- Correct intravascular volume depletion.
- Correct acidosis. Acidosis may reduce the effectiveness of phenylephrine.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter. Discard any unused portion.
What drugs interact with Biorphen?
Interactions That Augment Pressor Effect
The increasing blood pressure effect of Biorphen is increased in patients receiving:
- Monoamine oxidase inhibitors (MAOI)
- Oxytocin and oxytocic drugs
- Tricyclic antidepressants
- Angiotensin, aldosterone
- Steroids, such as hydrocortisone
- Norepinephrine transporter inhibitors, such as atomoxetine
- Ergot alkaloids, such as methylergonovine maleate
Interactions That Antagonize The Pressor Effect
The increasing blood pressure effect of Biorphen is decreased in patients receiving:
Is Biorphen safe to use while pregnant or breastfeeding?
- Data from randomized controlled trials and meta-analyses with phenylephrine hydrochloride injection use in pregnant women during caesarean section have not established a drug-associated risk of major birth defects and miscarriage.
- These studies have not identified an adverse effect on maternal outcomes or infant Apgar scores.
- There are no data on the use of phenylephrine during the first or second trimester.
- There are no data on the presence of Phenylephrine Hydrochloride Injection or its metabolite in human or animal milk, the effects on the breastfed infant, or the effects on milk production.
- The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for phenylephrine hydrochloride injection and any potential adverse effects on the breastfed infant from phenylephrine hydrochloride injection or from the underlying maternal condition.
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Biorphen (phenylephrine hydrochloride) is an alpha-1 adrenergic receptor agonist used to treat clinically important low blood pressure (hypotension) resulting primarily from vasodilation in the setting of anesthesia. Side effects of Biorphen include nausea, vomiting, and headache.
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Related Disease Conditions
What Is the Normal Blood Pressure Range?
Blood pressure is the force applied by the blood over the inner walls of the arteries. Although the average blood pressure for a person remains constant, it shows minor fluctuations throughout the day—declining while relaxing and momentarily increasing while being excited or under stress. An increase in the resting blood pressure can scar, stiffen, or harden the arteries.
Low Blood Pressure (Hypotension)
Low blood pressure, also referred to as hypotension, is blood pressure that is so low that it causes symptoms or signs due to the low flow of blood through the arteries and veins. Some of the symptoms of low blood pressure include light-headedness, dizziness, and fainting if not enough blood is getting to the brain. Diseases and medications can also cause low blood pressure. When the flow of blood is too low to deliver enough oxygen and nutrients to vital organs such as the brain, heart, and kidneys; the organs do not function normally and may be permanently damaged.
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What is low blood pressure and what causes it? Learn the signs and symptoms of low blood pressure and what you can do to treat it.
Orthostatic hypotension symptoms include: LightheadednessWeaknessBlurred vision Syncope or passing out Causes of orthostatic hypotension include: Dehydration, Anemia, Medication Blood loss Low blood pressure Heat related illnesses Parkinson's disease Diabetes Treatment of orthostatic hypotension depends on the underlying cause.
What Causes Low Blood Pressure in Pregnancy?
Low Blood Pressure (Hypotension) Causes
Low blood pressure (hypotension) occurs when blood pressure drops below the normal range. Low blood pressure can be temporary, or it can be a chronic (long-lasting) condition.
What Is “Normal” Blood Pressure?
Normal blood pressure is when the pressure is less than or upto 120/80 mmHg. The value 120 denotes the systolic pressure, and the value 80 denotes the diastolic pressure.
How Do I Know If I Have High or Low Blood Pressure Numbers?
High or low blood pressure can lead to serious health conditions. Learn more about what you should do if your pressure is outside the ideal range.
What Can You Do For Treatment if Your Blood Pressure Is Too Low?
Learn what medical treatments can help with your low blood pressure and speed up your recovery.
Treatment & Diagnosis
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