Generic drug: phenylephrine hydrochloride

Brand name: Biorphen

What is Biorphen (phenylephrine hydrochloride), and how does it work?

Biorphen (phenylephrine hydrochloride) is an alpha-1 adrenergic receptor agonist used to treat clinically important low blood pressure (hypotension) resulting primarily from vasodilation in the setting of anesthesia.

What are the side effects of Biorphen?

Side effects of Biorphen include:

What is the dosage for Biorphen?

General Dosage And Administration Instructions

During Biorphen administration:

  • Correct intravascular volume depletion.
  • Correct acidosis. Acidosis may reduce the effectiveness of phenylephrine.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Do not use if the solution is colored or cloudy, or if it contains particulate matter. Discard any unused portion.

What drugs interact with Biorphen?

Interactions That Augment Pressor Effect

The increasing blood pressure effect of Biorphen is increased in patients receiving:

Interactions That Antagonize The Pressor Effect

The increasing blood pressure effect of Biorphen is decreased in patients receiving:

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Is Biorphen safe to use while pregnant or breastfeeding?

  • Data from randomized controlled trials and meta-analyses with phenylephrine hydrochloride injection use in pregnant women during caesarean section have not established a drug-associated risk of major birth defects and miscarriage.
  • These studies have not identified an adverse effect on maternal outcomes or infant Apgar scores.
  • There are no data on the use of phenylephrine during the first or second trimester.
  • There are no data on the presence of Phenylephrine Hydrochloride Injection or its metabolite in human or animal milk, the effects on the breastfed infant, or the effects on milk production.
  • The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for phenylephrine hydrochloride injection and any potential adverse effects on the breastfed infant from phenylephrine hydrochloride injection or from the underlying maternal condition.

Summary

Biorphen (phenylephrine hydrochloride) is an alpha-1 adrenergic receptor agonist used to treat clinically important low blood pressure (hypotension) resulting primarily from vasodilation in the setting of anesthesia. Side effects of Biorphen include nausea, vomiting, and headache.

Treatment & Diagnosis

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Medically Reviewed on 3/30/2021
References
All sections courtesy of the U.S. Food and Drug Administration