- Side Effects
- Drug Interactions
What is Bijuva (estradiol and progesterone), and what is it used for?
What are the side effects of Bijuva?
Side effects are grouped by how serious they are and how often they happen when you are treated.
Serious but less common side effects include:
- heart attack
- blood clots
- breast cancer
- cancer of the lining of the uterus (womb)
- cancer of the ovary
- gallbladder disease
- high or low blood calcium levels
- changes in vision
- high blood pressure
- high levels of fat in your blood (triglycerides)
- liver problems
- changes in thyroid hormone levels
- swelling or fluid retention
- enlargement of benign tumors of the uterus (“fibroids”)
- worsening swelling of face or tongue (angioedema) in women who have a history of angioedema
- changes in laboratory test results such as bleeding time and high blood sugar levels
Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:
- new breast lumps
- unusual vaginal bleeding
- changes in vision or speech
- sudden new severe headaches
- severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
- swelling of legs or calves
The most common side effects of Bijuva include:
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all of the possible side effects of Bijuva. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA- 1088.
You may also report side effects to TherapeuticsMD at 1-888-228-0150.
What can I do to lower my chances of a serious side effect with Bijuva?
- Talk with your healthcare provider regularly about whether you should continue taking Bijuva.
- If you have a uterus, talk with your healthcare provider about whether the addition of a progestogen is right for you.
- The addition of a progestogen is generally recommended for a woman with a uterus to reduce the chance of getting cancer of the uterus (womb).
- See your healthcare provider right away if you get vaginal bleeding while taking Bijuva.
- Have a pelvic exam, breast exam and mammogram (breast X-ray) every year unless your healthcare provider tells you something else.
- If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram (breast X-ray), you may need to have breast exams more often.
- If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or if you use tobacco, you may have higher chances for getting heart disease.
Ask your healthcare provider for ways to lower your chances for getting heart disease.
What is the dosage for Bijuva?
Use of estrogen, alone or in combination with a progestogen, should be limited to the lowest effective dose available and for the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should be reevaluated periodically as clinically appropriate to determine if treatment is still necessary.
Treatment Of Moderate To Severe Vasomotor Symptoms Due To Menopause
Take a single Bijuva (estradiol and progesterone) capsule, 1 mg/100 mg, orally each evening with food.
What drugs interact with Bijuva?
No drug-drug interaction studies have been conducted with Bijuva.
In-vitro and in-vivo studies have shown that estrogens and progestins are metabolized partially by cytochrome P450 3A4 (CYP3A4). Therefore, inducers or inhibitors of CYP3A4 may affect estrogen and progestin drug metabolism. Inducers of CYP3A4 such as St. John's wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce plasma concentrations of estrogens and progestins, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. Inhibitors of CYP3A4, such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice, may increase plasma concentrations of the estrogen or the progestin or both and may result in side effects.
Bijuva contraindications, and pregnancy and breastfeeding safety
Do not take Bijuva if you have had your uterus (womb) removed (hysterectomy).
Bijuva contains progesterone to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need progesterone and you should not take Bijuva.
Do not take Bijuva if you:
- have any unusual vaginal bleeding. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
- currently have or have had certain cancers. Estrogens may increase the chances of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should take Bijuva.
- currently have or have had blood clots.
- had a stroke or heart attack.
- currently have or have had liver problems.
- have been diagnosed with a bleeding disorder.
- are allergic to Bijuva or any of its ingredients. See the list of ingredients in Bijuva in the prescribing information.
Bijuva (estradiol and progesterone) capsules, 1 mg/100 mg, are not indicated for use in pregnancy. There are no data with the use of Bijuva in pregnant women, however, epidemiologic studies and meta-analyses have not found an increased risk of genital or non-genital birth defects (including cardiac anomalies and limbreduction defects) following exposure to combined hormonal contraceptives (estrogen and progestins) before conception or during early pregnancy.
Bijuva (estradiol and progesterone) capsules, 1 mg/100 mg, are not indicated for use in females of reproductive potential. Estrogens are present in human milk and can reduce milk production in breastfeeding females. This reduction can occur at any time but is less likely to occur once breastfeeding is well-established.
Bijuva is a prescription medication that contains the hormones estrogen and progesterone, which is used after menopause to reduce hot flashes. The most common side effects of Bijuva include breast tenderness, headache, vaginal bleeding, vaginal discharge, and pelvic pain. Do not take Bijuva if you have had your uterus (womb) removed (hysterectomy).
Multimedia: Slideshows, Images & Quizzes
Menopause & Perimenopause: Symptoms, Signs
What is menopause? What are the signs of menopause? What age does menopause start? Learn about menopause and perimenopause...
What Causes Hot Flashes?
Menopause isn't the only thing that causes flushing (hot flashes). Find out what else can trigger these sudden waves of heat as...
Menopause Quiz: Symptoms & Signs
The Menopause Quiz challenges your knowledge about the time in a woman’s life when menstruation ceases. Menopause can bring many...
9 Signs of Perimenopause
Perimenopause occurs before menopause as estrogen levels begin to change. This can cause menopause like symptoms such as hot...
Women's Health: 10 Tips to Ease Menopause Symptoms
What happens during menopause? At what age do menopause symptoms start? Women in their 40s or 50s may begin to have hot flashes,...
Related Disease Conditions
Menopause is the time in a woman's life when menstrual periods permanently stop, also called the "change of life." Menopause symptoms and signs include hot flashes, night sweats, irregular vaginal bleeding, vaginal dryness, painful intercourse, urinary incontinence, weight gain, and emotional symptoms such as mood swings. Treatment of menopausal symptoms varies and should be discussed with your physician.
Sex and Menopause
Can a Partial Hysterectomy Cause Hormonal Imbalance?
A partial hysterectomy may affect your hormones. Understand the signs of hormonal imbalance, how doctors diagnose hormonal imbalance, and what you can do to treat hormonal imbalance after partial hysterectomy.
Is There Any Way to Have a Baby After a Hysterectomy?
Hysterectomy is the surgical removal of a woman's uterus (also known as the womb). Hence, a woman who has had a hysterectomy cannot have babies in the normal way. However, with the development of research in medical science, a couple may have a baby after a hysterectomy via surrogacy or uterus transplantation.
Perimenopause is the time in a woman's life when she is approaching menopause. During this time a woman starts to develop symptoms of declining estrogen levels that may include mood swings, painful sex, night sweats, hot flashes, and weight gain. Every adult woman eventually will experience perimenopause.
Hot flashes (or flushing) is the most common symptom experienced by a woman prior to and during the early stages of menopause, and often is described as the feeling of warmth that spreads over the body, often starting at the head accompanied by sweating. Symptoms of hot flashes include flushing, excessive sweating, anxiety, and palpitations.
Duration of Bed Rest After a Hysterectomy
Patients will need good bed rest after a hysterectomy. Most patients need a good recuperation post a hysterectomy. Rest is the key ingredient of the healing process. The body usually needs 15-30 days to recover from the surgery; however, the length of recovery and rest depends on the age, general level of health, and type of hysterectomy.
Does Sex Drive Return After Menopause?
Menopause is defined as when you haven't had your periods for 12 consecutive months. You should accept the fact that it is normal to experience changes in sexual desire after menopause.
Recovery Time for a Laparoscopic Hysterectomy
Hysterectomy is the surgical removal of the uterus. Laparoscopic hysterectomy is a minimally invasive surgical procedure to remove the uterus. The recovery is faster, and post-operative discomfort is minimal with a laparoscopic hysterectomy.
Can You Have a Hysterectomy With C-Section?
Hysterectomy (surgical removal of the uterus) may be performed during Cesarean delivery and is referred to as a Cesarean hysterectomy. It involves the removal of the uterus at the time of Cesarean delivery.
What to Expect After a Laparoscopic Hysterectomy?
The first 24 hours after hysterectomy, patients may experience some vaginal bleeding that tapers off. If the bleeding seems to be getting heavier rather than lighter, the physician should be notified immediately.
What Is the Difference Between a Total and Radical Hysterectomy?
Hysterectomy is the surgical removal of the uterus. It is the second most commonly performed surgery in non-pregnant women. A total hysterectomy involves the removal of the whole uterus and cervix, whereas a radical hysterectomy is the removal of the whole uterus and its adjacent tissues (ligaments), cervix and some part of the vagina.
Premature menopause is when menopause occurs in a woman before the age of 40. Causes of premature menopause include premature ovarian failure, treatments for cancer and other conditions, surgical removal of the ovaries, chronic diseases of the pituitary or thyroid gland, or psychiatric disorders. Treatment is directed at menopausal symptoms.
What Are the 40 Symptoms of Menopause?
Menopause is the end of the reproductive era of a woman's life that is characterized by drastic changes in her emotional and physical aspects. Studies have identified around 40 signs and symptoms of menopause, but not every woman gets all of them.
How Long Does Vaginal Hysterectomy Take?
Vaginal hysterectomy is a surgical procedure to remove the uterus through the vagina. When the uterus is removed by making an incision over the abdomen, the surgical procedure is called abdominal hysterectomy. The choice of surgery depends on the size and shape of the uterus and the indication for surgery, which is up to the surgeon.
Male menopause refers to the decline in testosterone production in men. As men age, they often experience many of the same symptoms that women experience in menopause. Testosterone replacement therapy may relieve some of these symptoms.
Natural Remedies for Hot Flashes
Hot flashes are experienced by many women, especially at night. However, not all women undergoing menopause experience hot flashes. What causes hot flashes? A hot flash is a feeling of warmth that spreads over the body. Treatment for hot flashes include hormone replacement therapy and alternative prescription medications such as: SSRIs (Effexor, Paxil, Prozac), clonidine (Catapres), megestrol (Megace), and gabapentin (Neurontin). Few natural remedies for hot flashes (for example phytoestrogens - isoflavones, black cohosh, and vitamin E) have been scientifically studied.
What Does Radical Hysterectomy Mean?
Hysterectomy is a surgery for the removal of the uterus. Depending on whether there is the removal of other organs or tissues, hysterectomy may be of different types. Radical hysterectomy is a surgery that involves the removal of the entire uterus along with its supporting tissues, cervix (the neck of the uterus), and the vagina.
What Happens When You Have a Hysterectomy?
Hysterectomy is a major surgery that ends up impacting a woman’s life considerably.
Sex and Menopause
Menopause is often associated with a change in sexual functioning. Loss of estrogen, bladder control issues, anxiety, stress, health concerns, medications, and sleep disturbances often result in a decrease in libido. Though there are currently no good drugs for treating sexual problems in women, there are ways to increase intimacy with a partner and treat vaginal dryness.
15 Things Women Should Know About Menopause
Menopause is a phase in a woman's life that challenges her physically and emotionally. Many women deal with menopause without any medical treatments, whereas some women with severe symptoms require therapies.
What Is the Most Common Reason for a Hysterectomy?
A hysterectomy is a major operation for a woman that involves the removal of her uterus. It is the most common non-pregnancy-related surgery performed in women in the United States.
Sexual Side Effects of Menopause
Menopause marks the end of the reproductive era in a woman's life. Some women view it positively as periods no longer trouble them and there is no chance of getting pregnant even with unprotected sex. However, as estrogen and testosterone levels take a plunge during menopause, some women experience the sexual side effects of menopause.
Treatment & Diagnosis
- Hot Flashes
- Male Menopause
- Menopause: Making it the Best Years of Your Life
- Menopause: Super Nutrition for Menopause
- Menopause and Perimenopause, A Woman's Guide to
- Menopause: The Men's Guide to Understanding It
- Menopause: A New Perspective
- Menopause: Change of Life, Change of Diet
- Premature Menopause
- Hormone Therapy After Menopause -- Susan Love, MD
- Menopause: Taking Charge
- Menopause Made Easy with Carolle Jean-Murat
- Menopause FAQs
- Thyroid Disease and Menopause
- Menopause: Home Menopause Test Kits, Are They Worth It?
- Hysterectomy: A New Type of Hysterectomy
- Hot Flashes: Anxiety Worsens Hot Flashes
- The Women's Health Initiative in Perspective: The Last Straw for Estrogen Therapy?
- Can Menopause Cause High Cholesterol?
- How Is Menopause Diagnosed After a Hysterectomy?
- Could Cervical Cancer Recur After Hysterectomy?
- Can You Still Retain Symptoms Of PCOD (Acne, Obesity, Etc.) After Hysterectomy?
- How Does Menopause Affect Polycystic Ovarian Syndrome (PCOS)?
- Does Vaginal Moisture Change During Perimenopause?
- Do Soy Isoflavones Treat Menopause Hot Flashes?
- Can You Go Through Menopause at 40?
- Does Perimenopause Cause Mood Swings?
- Does Menopause Cause Pain During Sex?
- Does Menopause Affect Memory?
- Are Night Sweats a Sign of Menopause?
- Can Soy Help Menopause Symptoms?
- Do I Need Birth Control After Menopause?
- Does Menopause Cause High Blood Pressure?
- Do I Need a Pap Smear if I've Had a Hysterectomy?
- Do You Get More UTIs During Menopause?
- Can You Still Get Menopause After Hysterectomy?
- Do All Women Get Menopause?
- Male Menopause
- Menopause: 10 Questions To Ask Your Doctor
- Menopause Symptoms
- Ask the Experts - Menopause
- Menopause: Change of Life, Change of Diet
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.