bepridil (Vascor, Bepadin - Discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Is bepridil available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for bepridil?

Yes

What are the uses for bepridil?

Bepridil is prescribed for patients with angina pectoris (heart pain) due to coronary artery disease.

What are the side effects of bepridil?

  • Bepridil can cause very serious cardiac arrhythmias. The risk is increased in patients with a specific electrocardiographic abnormality called QT prolongation and in patients with low blood concentrations of potassium or magnesium.
  • Bepridil also can cause increased or decreased heart rate and other abnormal rhythms.

Other side effects that can occur among patients taking bepridil include:

What is the dosage for bepridil?

Bepridil usually is taken once daily. It can be taken with meals or at bedtime if nausea is a problem.

Which drugs or supplements interact with bepridil?

  • Bepridil can reduce the strength with which the heart muscle contracts. Drugs which also have this effect when given together with bepridil could seriously reduce contraction of the heart and possibly precipitate congestive heart failure. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), verapamil (Calan; Isoptin; Covera; Verelan), diltiazem (Cardizem; Tiazac; Dilacor), and all beta-blockers, for example, atenolol (Tenormin).
  • Bepridil slows the ability of the heart's muscle to recover electrically and get ready for the next contraction. Other drugs which have the same effect could interact with bepridil, possibly causing serious problems with abnormal heart rhythms and should be used cautiously if at all with bepridil. Such drugs include quinidine (Quinaglute; Duraquin; Quinidex), procainamide (Procan-SR; Pronestyl), disopyramide (Norpace), flecainide (Tambocor), and tricyclic antidepressants, for example, amitriptyline (Elavil, Endep).
  • Bepridil may increase levels of digoxin (Lanoxin) in the blood, thereby increasing the risk of digoxin toxicity.
  • Diuretics, for example, furosemide (Lasix), bumetanide (Bumex), torsemide Demadex), hydrochlorothiazide (Hydrodiuril), chlorthalidone (Hygroton), metolazone (Zaroxolyn) may cause a reduction in blood potassium concentrations thereby increasing the risk of bepridil-induced abnormal heart rhythms.

Is bepridil safe to take if I'm pregnant or breastfeeding?

  • Bepridil crosses the placenta, and therefore should not be used during pregnancy unless the benefit to the mother outweighs the potential but unknown risk to the fetus.
  • Bepridil is secreted into breast milk and therefore should not be used by breastfeeding mothers unless benefit to the mother clearly outweighs the potential but unknown risk to the infant.

What else should I know about bepridil?

What preparations of bepridil are available?

Tablets: 200 mg.

How should I keep bepridil stored?

Tablets should be stored at room temperature, 15C to 30 C (59 F to 86 F).

Reference: FDA Prescribing Information

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See more info: bepridil on RxList
Reviewed on 9/21/2016
References
Reference: FDA Prescribing Information

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