- What other names is Bee Venom known by?
- What is Bee Venom?
- How does Bee Venom work?
- Are there safety concerns?
- Are there any interactions with medications?
- Dosing considerations for Bee Venom.
pollen, honey, or royal jelly. Other venoms are derived from related members of the insect order Hymenoptera.
Bee venom is given as a shot for rheumatoid arthritis, nerve pain (neuralgia), multiple sclerosis (MS), reducing the reaction to bee stings in people who are allergic (desensitization) to them (venom immunotherapy), swollen tendons (tendonitis), and muscle conditions such as fibromyositis and enthesitis.
Likely Effective for...
- Reducing the severity of allergic reactions to bee stings. A series of bee venom shots under the skin (bee venom immunotherapy) seems to be effective for reducing reactions to bee stings in people with severe allergy to bee stings. Bee venom immunotherapy provides 98% to 99% protection from reactions to bee stings. Once immunotherapy is stopped, the risk of reaction over the next 5 to 10 years is about 5% to 15%. Purified bee venom for under-the-skin injection is an FDA approved product.
Possibly Ineffective for...
- Arthritis. People used to think that bee venom might be a useful treatment for arthritis. This theory was largely due to supposed swelling-reducing (anti-inflammatory) effects of bee venom and the observation that many beekeepers don't develop arthritis. However, research results have not supported this.
- Multiple sclerosis (MS). Administering live bee stings in gradually increasing doses up to 20 stings given three times weekly does not seem to improve multiples sclerosis. Treatment for 24 weeks does not seem to improve fatigue, disability, or quality of life.
Insufficient Evidence to Rate Effectiveness for...
- Nerve pain.
- Painful, swollen tendons (tendonitis).
- Muscle swelling (inflammation).
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itching, anxiety, trouble breathing, chest tightness, heart palpitations, dizziness, nausea, vomiting, diarrhea, sleepiness, confusion, fainting, and low blood pressure.
Side effects are more common in people with the worst allergies to bee stings, in people treated with honeybee venom, and in women.
Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks.
Special Precautions & Warnings:Pregnancy and breast-feeding: Bee venom seems to be safe when injected under the skin by a trained medical professional at recommended doses. Though harmful effects at usual doses have not been reported, some healthcare providers decrease the maintenance dose by half during pregnancy. High doses of bee venom are UNSAFE during pregnancy because they can increase release of a chemical called histamine, which can cause the uterus to contract. This might lead to miscarriage. Avoid high doses of bee venom if you are pregnant.
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Bee venom might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using bee venom.
Medications that decrease the immune system (Immunosuppressants)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.
Bee venom might increase the immune system. By increasing the immune system, bee venom might decrease the effectiveness of medications that decrease the immune system.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
- For reducing the severity of allergic reactions to bee stings: Healthcare providers give bee venom as a shot (by injection) to "desensitize" people who are allergic to bee stings. Purified bee venom for under-the-skin injection is an FDA approved product.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Last Editorial Review: 3/29/2011