Barbiturates

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What are examples barbiturates of available in the US?

Examples of barbiturates available in the US include:

What are the side effects of barbiturates?

Common side effects of barbiturates are:

Barbiturates can slow breathing, reduce heart rate, and they can be habit forming.

What drugs interact with barbiturates?

Barbiturates should be used with caution with some medications because they accelerate the breakdown of these medications leading to decreased effectiveness. Examples of these medications that interact with barbiturates include:

Concomitant use of barbiturates and other central nervous system depressant medications should be used with caution because concomitant use can lead to excessive sedation, lethargy, and in severe cases coma and death. Examples of these medications that should be used with caution with other central nervous system depressant medications such as:

What formulations of are available barbiturates?

  • Amobarbital and pentobarbital are available as injections.
  • Butabarbital, phenobarbital, belladonna and phenobarbital, butalbital/aspirin/caffeine, and butalbital/acetaminophen/caffeine are available as tablets.
  • Butalbital/acetaminophen/caffeine, butalbital/aspirin/caffeine, and secobarbital are available as capsules.
  • Butabarbital, phenobarbital, belladonna and phenobarbital, and butalbital/acetaminophen/caffeine are available as oral liquids.

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What about taking barbiturates during pregnancy or while breastfeeding?

FDA has listed amobarbital, phenobarbital, pentobarbital, secobarbital as Pregnancy Category D. This means they should not be used during pregnancy. FDA has listed belladonna and phenobarbital, butabarbital, butalbital/acetaminophen/caffeine, and butalbital/acetaminophen/caffeine as Pregnancy Category C. Pregnancy Category C classification means that there is no evidence of safe and effective use of barbiturates established for pregnant women. Therefore, risk to the infant cannot be ruled out. It is not known whether barbiturates enter breast milk; however, barbiturates should be avoided in nursing mothers to avoid harm to the infant.

REFERENCE: Medscape. Anticonvulsants, Barbiturates.

Summary

Barbiturates are a class of drugs prescribed to treat headaches, insomnia, and seizures. Examples of barbiturates include:

Side effects, drug interactions, dosage, storage, and pregnancy safety should be reviewed prior to taking this medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

Quick GuideMigraine or Headache? Migraine Symptoms, Triggers, Treatment

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Reviewed on 2/6/2017
References
REFERENCE: Medscape. Anticonvulsants, Barbiturates.

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