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- What is balsalazide disodium, and how does it work (mechanism of action)?
- What brand names are available for balsalazide disodium?
- Is balsalazide disodium available as a generic drug?
- Do I need a prescription for balsalazide disodium?
- What is the dosage for balsalazide disodium?
- Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
- What else should I know about balsalazide disodium?
What is balsalazide disodium, and how does it work (mechanism of action)?
Balsalazide disodium is an oral anti-inflammatory drug that is used for the treatment of ulcerative colitis. It is a form of mesalamine (5-aminosalicyclic acid) that is activated by colonic bacteria when it reaches the colon. The exact mechanism of action of mesalamine is not known but is believed to be by reducing inflammation in the colon. Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals, for example, prostaglandins, that produce inflammation in the colon. Prostaglandins are produced by the enzymes, cyclooxygenase and lipoxygenase. These enzymes are over-active in individuals with ulcerative colitis. Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, thereby, reducing the production of prostaglandins. Reduced production of prostaglandins decreases inflammation in the colon and the symptoms associated with ulcerative colitis. Other branded, mesalamine-containing drugs include mesalamine (Pentasa, Rowasa, and Asacol). Balsalazide disodium was approved by the FDA in July 2000.
Quick GuideUlcerative Colitis Symptoms, Causes, and Treatment
What is the dosage for balsalazide disodium?
The usual dose is 2250 mg (three 750 mg capsules) taken three times daily for 8 to 12 weeks or three 1.1 g tablets two times a day for up to 8 weeks.
Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
Animal studies have not demonstrated any adverse effects on the fetus; however, there have been no studies in pregnant women. Balsalazide should only be used during pregnancy if the benefit outweighs the theoretical risks.
It is not known if balsalazide disodium is secreted into breast milk. Since many drugs are secreted into breast milk, balsalazide disodium should not be taken by nursing women.
What else should I know about balsalazide disodium?
What preparations of balsalazide disodium are available?
PREPARATIONS: Capsule: 750 mg; Tablet: 1.1 g
How should I keep balsalazide disodium stored?
Balsalazide disodium should be stored between 15 C to 30 C (59 F to 86 F)
balsalazide disodium (Colazal, Giazo) is a drug prescribed for the treatment of the signs and symptoms of mild to moderately ulcerative colitis. Side effects, drug interactions, and warnings and precautions should be reviewed prior to taking any medicication.
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Top balsalazide disodium Related Articles
ColitisColitis refers to inflammation of the inner lining of the colon. Symptoms of the inflammation of the colon lining include diarrhea, pain, and blood in the stool. There are several causes of colitis, including infection, ischemia of the colon, inflammatory bowel disease (Crohn's disease, ulcerative colitis, infectious colitis like C. difficile, or microscopic colitis). Treatment depends on the cause of the colitis.
Crohn's DiseaseCrohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect other parts of the digestive system as well. Abdominal pain, diarrhea, vomiting, fever, and weight loss are common symptoms.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
mesalamineMesalamine (Pentasa, Rowasa, SfRowasa, Lialda, Canasa, Apriso, Delzicol) is a medication prescribed for ulcerative colitis and mild to moderate Crohn's disease. Side effects, drug interactions, warnings and precautions, and safety during pregnancy information should be reviewed prior to taking this medication.
Ulcerative ColitisUlcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
Ulcerative Colitis QuizWhat is ulcerative colitis and what risks are associated with suffering over the long term? Take this Ulcerative Colitis Quiz to learn causes, symptoms, and treatments for this painful digestive disorder.
Ulcerative Colitis Diet
An ulcerative colitis diet plan can help a person with the disease avoid foods and drinks that trigger flares. There also are foods that can soothe ulcerative colitis symptoms during a flare. Types of ulcerative colitis plans include
- a high-calorie diet,
- a lactose-free diet,
- a low-fat diet,
- a low-fiber diet (low-residue diet), or
- a low-salt diet.
Self-management of ulcerative colitis using healthy lifestyle habits and a nutrient rich diet can be effective in management of the disease. Learn what foods to avoid that aggravate, and what foods help symptoms of the disease and increase bowel inflammation.
Ulcerative Colitis SurgeryUlcerative colitis surgery is performed on approximately 25% to 40% of people with the disease. There are various types of ulcerative colitis. Complications of the surgery include pouch failure, intestinal blockage from adhesions, inflammation of the pouch, and more watery and frequent bowel movements.