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- What is balsalazide disodium, and how does it work (mechanism of action)?
- What are the uses for balsalazide disodium?
- What are the side effects of balsalazide disodium?
- What is the dosage for balsalazide disodium?
- What drugs interact with balsalazide disodium?
- Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
- What else should I know about balsalazide disodium?
What is balsalazide disodium, and how does it work (mechanism of action)?
Balsalazide disodium is an oral anti-inflammatory drug that is used for the treatment of ulcerative colitis. It is a form of mesalamine (5-aminosalicyclic acid) that is activated by colonic bacteria when it reaches the colon. The exact mechanism of action of mesalamine is not known but is believed to be by reducing inflammation in the colon. Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals, for example, prostaglandins, that produce inflammation in the colon. Prostaglandins are produced by the enzymes, cyclooxygenase and lipoxygenase. These enzymes are over-active in individuals with ulcerative colitis. Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, thereby, reducing the production of prostaglandins. Reduced production of prostaglandins decreases inflammation in the colon and the symptoms associated with ulcerative colitis. Other branded, mesalamine-containing drugs include mesalamine (Pentasa, Rowasa, and Asacol). Balsalazide disodium was approved by the FDA in July 2000.
What brand names are available for balsalazide disodium?
Is balsalazide disodium available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for balsalazide disodium?
What are the uses for balsalazide disodium?
Balsalazide disodium is a locally acting aminosalicylate indicated for the treatment of mildly to moderately active ulcerative colitis in patients 5 years of age and older. Safety and effectiveness of balsalazide disodium beyond 8 weeks in children (ages 5-17 years) and 12 weeks in adults have not been established.
What are the side effects of balsalazide disodium?
Contact your doctor if:
- You experience a worsening of your ulcerative colitis symptoms.
- You are diagnosed with pyloric stenosis, because balsalazide disodium capsules may be slow to pass through your digestive tract.
- You are diagnosed with renal dysfunction. Damage to the kidney has been observed in people given medications similar to balsalazide disodium.
- You are diagnosed with liver disease. Worsening liver disease has been observed in some people given medications similar to balsalazide disodium.
In adult clinical trials the most common side effects were:
In the pediatric clinical trial the most common side effects were:
This is not a complete list of side effects. Discuss potential side effects with your doctor.
What is the dosage for balsalazide disodium?
The usual dose is 2250 mg (three 750 mg capsules) taken three times daily for 8 to 12 weeks or three 1.1 g tablets two times a day for up to 8 weeks.
What drugs interact with balsalazide disodium?
Do not take balsalazide disodium if you have a hypersensitivity to salicylates such as aspirin.
Based upon limited studies conducted in a test tube, balsalazide disodium does not appear to interfere with other drugs by preventing how the liver functions. However, as the studies were limited in scope, always consult your doctor and discuss potential interactions prior to initiating any new drug.
Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
Animal studies have not demonstrated any adverse effects on the fetus; however, there have been no studies in pregnant women. Balsalazide disodium should only be used during pregnancy if the benefit outweighs the risks.
What else should I know about balsalazide disodium?
What preparations of balsalazide disodium are available?
PREPARATIONS: Capsule: 750 mg; Tablet: 1.1 g
How should I keep balsalazide disodium stored?
Balsalazide disodium should be stored between 15 C to 30 C (59 F to 86 F)
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Balsalazide disodium (Colazal, Giazo) is a drug prescribed for the treatment of the signs and symptoms of mild to moderate ulcerative colitis. Review side effects, drug interactions, and warnings and precautions prior to taking any medication.
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Related Disease Conditions
Colitis refers to inflammation of the inner lining of the colon. Symptoms of the inflammation of the colon lining include diarrhea, pain, and blood in the stool. There are several causes of colitis, including infection, ischemia of the colon, inflammatory bowel disease (Crohn's disease, ulcerative colitis, infectious colitis like C. difficile, or microscopic colitis). Treatment depends on the cause of the colitis.
An ulcerative colitis diet plan can help a person with the disease avoid foods and drinks that trigger flares. There also are foods that can soothe ulcerative colitis symptoms during a flare. Types of ulcerative colitis plans include a high-calorie diet, a lactose-free diet, a low-fat diet, a low-fiber diet (low-residue diet), or a low-salt diet. Self-management of ulcerative colitis using healthy lifestyle habits and a nutrient rich diet can be effective in management of the disease. Learn what foods to avoid that aggravate, and what foods help symptoms of the disease and increase bowel inflammation.
Crohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect other parts of the digestive system as well. Abdominal pain, diarrhea, vomiting, fever, and weight loss are common symptoms.
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
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