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- What is balsalazide disodium, and how does it work (mechanism of action)?
- What brand names are available for balsalazide disodium?
- Is balsalazide disodium available as a generic drug?
- Do I need a prescription for balsalazide disodium?
- What is the dosage for balsalazide disodium?
- Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
- What else should I know about balsalazide disodium?
What is balsalazide disodium, and how does it work (mechanism of action)?
Balsalazide disodium is an oral anti-inflammatory drug that is used for the treatment of ulcerative colitis. It is a form of mesalamine (5-aminosalicyclic acid) that is activated by colonic bacteria when it reaches the colon. The exact mechanism of action of mesalamine is not known but is believed to be by reducing inflammation in the colon. Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals, for example, prostaglandins, that produce inflammation in the colon. Prostaglandins are produced by the enzymes, cyclooxygenase and lipoxygenase. These enzymes are over-active in individuals with ulcerative colitis. Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, thereby, reducing the production of prostaglandins. Reduced production of prostaglandins decreases inflammation in the colon and the symptoms associated with ulcerative colitis. Other branded, mesalamine-containing drugs include mesalamine (Pentasa, Rowasa, and Asacol). Balsalazide disodium was approved by the FDA in July 2000.
What is the dosage for balsalazide disodium?
The usual dose is 2250 mg (three 750 mg capsules) taken three times daily for 8 to 12 weeks or three 1.1 g tablets two times a day for up to 8 weeks.
Is balsalazide disodium safe to take if I'm pregnant or breastfeeding?
Animal studies have not demonstrated any adverse effects on the fetus; however, there have been no studies in pregnant women. Balsalazide should only be used during pregnancy if the benefit outweighs the theoretical risks.
It is not known if balsalazide disodium is secreted into breast milk. Since many drugs are secreted into breast milk, balsalazide disodium should not be taken by nursing women.
What else should I know about balsalazide disodium?
What preparations of balsalazide disodium are available?
PREPARATIONS: Capsule: 750 mg; Tablet: 1.1 g
How should I keep balsalazide disodium stored?
Balsalazide disodium should be stored between 15 C to 30 C (59 F to 86 F)
Quick GuideUlcerative Colitis Symptoms, Causes, and Treatment
balsalazide disodium (Colazal, Giazo) is a drug prescribed for the treatment of the signs and symptoms of mild to moderately ulcerative colitis. Side effects, drug interactions, and warnings and precautions should be reviewed prior to taking any medicication.
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